Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) SprG3-SprA2AS/-
Location 2118123..2118320 Replicon chromosome
Accession NZ_CP020354
Organism Staphylococcus aureus strain FORC59

Toxin (Protein)


Gene name SprG3 Uniprot ID Q2FWA7
Locus tag FORC59_RS10820 Protein ID WP_001802298.1
Coordinates 2118216..2118320 (-) Length 35 a.a.

Antitoxin (RNA)


Gene name SprA2AS
Locus tag -
Coordinates 2118123..2118161 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FORC59_RS10800 2114298..2114963 - 666 WP_001024095.1 SDR family oxidoreductase -
FORC59_RS10805 2115115..2115435 + 321 WP_000003755.1 Zn(II)-responsive metalloregulatory transcriptional repressor CzrA -
FORC59_RS10810 2115437..2116417 + 981 WP_000019743.1 CDF family zinc efflux transporter CzrB -
FORC59_RS10815 2116683..2117774 + 1092 WP_000495681.1 hypothetical protein -
- 2118123..2118161 + 39 - - Antitoxin
FORC59_RS10820 2118216..2118320 - 105 WP_001802298.1 hypothetical protein Toxin
FORC59_RS10830 2119000..2119158 + 159 WP_001792784.1 hypothetical protein -
FORC59_RS10840 2119816..2120673 - 858 WP_000370928.1 Cof-type HAD-IIB family hydrolase -
FORC59_RS10845 2120741..2121523 - 783 WP_000908189.1 ABC transporter ATP-binding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(3-120)


Sequences

Toxin        


Download         Length: 35 a.a.        Molecular weight: 3906.77 Da        Isoelectric Point: 5.5724

>T74364 WP_001802298.1 NZ_CP020354:c2118320-2118216 [Staphylococcus aureus]
MLLLERTSMSDFEMLMVVLTIIGLVLISTQDHKK

Download         Length: 105 bp

>T74364 NZ_CP020354:c2118320-2118216 [Staphylococcus aureus]
TTGTTACTCCTAGAAAGGACTAGCATGTCTGATTTTGAAATGCTGATGGTTGTATTAACAATCATTGGTTTAGTATTGAT
TAGTACTCAAGACCATAAAAAATAA

Antitoxin


Download         Length: 39 bp

>AT74364 NZ_CP020354:2118123-2118161 [Staphylococcus aureus]
AACATGTTACCCTAATGAGCCCGTTAAAAAGACGGTGAC

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2I7Y9L9

Antitoxin

Download structure file

References