Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) hok-sok/-
Location 2891966..2892191 Replicon chromosome
Accession NZ_CP020342
Organism Shigella flexneri 1a strain 0439

Toxin (Protein)


Gene name hokW Uniprot ID S1ELB5
Locus tag BS647_RS15230 Protein ID WP_000813254.1
Coordinates 2892036..2892191 (+) Length 52 a.a.

Antitoxin (RNA)


Gene name sokW
Locus tag -
Coordinates 2891966..2892024 (-)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BS647_RS15185 2887143..2888405 - 1263 Protein_2748 tyrosine-type recombinase/integrase -
BS647_RS15195 2888743..2889540 - 798 WP_001325918.1 DgsA anti-repressor MtfA -
BS647_RS15205 2889751..2890801 - 1051 Protein_2750 tyrosine-type recombinase/integrase -
BS647_RS15210 2890801..2890941 - 141 Protein_2751 DUF4224 domain-containing protein -
BS647_RS15215 2890968..2891384 + 417 WP_005069274.1 hypothetical protein -
- 2891966..2892024 - 59 - - Antitoxin
BS647_RS15230 2892036..2892191 + 156 WP_000813254.1 type I toxin-antitoxin system toxin HokD Toxin
BS647_RS15240 2892359..2892637 + 279 WP_011069426.1 hypothetical protein -
BS647_RS15245 2892639..2893697 + 1059 WP_001265248.1 DUF968 domain-containing protein -
BS647_RS15250 2893698..2894063 + 366 WP_000140020.1 RusA family crossover junction endodeoxyribonuclease -
BS647_RS15255 2894060..2894748 + 689 Protein_2757 bacteriophage antitermination protein Q -
BS647_RS15285 2895544..2895759 + 216 WP_000839572.1 class II holin family protein -
BS647_RS15290 2895858..2896532 + 675 WP_004967157.1 IS66-like element accessory protein TnpA -
BS647_RS15295 2896529..2896879 + 351 WP_005049241.1 IS66 family insertion sequence element accessory protein TnpB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - ipaH9.8 2884376..2924818 40442


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Hok/gef cell toxic protein

(6-47)


Sequences

Toxin        


Download         Length: 52 a.a.        Molecular weight: 5736.89 Da        Isoelectric Point: 6.1531

>T74313 WP_000813254.1 NZ_CP020342:2892036-2892191 [Shigella flexneri 1a]
MKQQKAMLIALIVICLTVIVTALVTRKDLCEVRIRTGQTEVAVFTAYEPEE

Download         Length: 156 bp

>T74313 NZ_CP020342:2892036-2892191 [Shigella flexneri 1a]
ATGAAGCAGCAAAAGGCGATGTTAATCGCCCTTATCGTCATCTGTTTAACCGTCATAGTGACGGCACTGGTAACGAGGAA
AGACCTCTGCGAGGTACGAATCCGAACCGGCCAGACGGAGGTCGCTGTCTTCACAGCTTACGAACCTGAGGAGTAA

Antitoxin


Download         Length: 59 bp

>AT74313 NZ_CP020342:c2892024-2891966 [Shigella flexneri 1a]
CCTTGCCTTTCGGCACGTAAGAGGCTAACCTACATGTGTTCAGCATGGATTGAGCCTCA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A4P7TMW0

Antitoxin

Download structure file

References