Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | higBA (relBE)/HTH(antitoxin) |
Location | 4647425..4648091 | Replicon | chromosome |
Accession | NZ_CP020335 | ||
Organism | Photorhabdus akhurstii strain 0813-124 phase II |
Toxin (Protein)
Gene name | higB | Uniprot ID | - |
Locus tag | B0X70_RS20100 | Protein ID | WP_217470238.1 |
Coordinates | 4647425..4647748 (+) | Length | 108 a.a. |
Antitoxin (Protein)
Gene name | higA | Uniprot ID | - |
Locus tag | B0X70_RS20105 | Protein ID | WP_113044380.1 |
Coordinates | 4647795..4648091 (+) | Length | 99 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
B0X70_RS20080 (B0X70_20290) | 4643439..4644095 | + | 657 | WP_217470234.1 | DUF2612 domain-containing protein | - |
B0X70_RS20085 (B0X70_20295) | 4644082..4645452 | + | 1371 | WP_217470235.1 | phage tail protein | - |
B0X70_RS20090 (B0X70_20300) | 4645452..4646078 | + | 627 | WP_217470236.1 | tail fiber assembly protein | - |
B0X70_RS25400 | 4646687..4647043 | - | 357 | Protein_3942 | Bro-N domain-containing protein | - |
B0X70_RS20100 (B0X70_20310) | 4647425..4647748 | + | 324 | WP_217470238.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
B0X70_RS20105 (B0X70_20315) | 4647795..4648091 | + | 297 | WP_113044380.1 | NadS family protein | Antitoxin |
B0X70_RS20110 | 4648515..4648736 | + | 222 | WP_217470239.1 | hypothetical protein | - |
B0X70_RS20115 (B0X70_20325) | 4648746..4649015 | + | 270 | WP_065390442.1 | helix-turn-helix transcriptional regulator | - |
B0X70_RS20120 (B0X70_20330) | 4649384..4649794 | - | 411 | WP_036808644.1 | type II toxin-antitoxin system HicB family antitoxin | - |
B0X70_RS20125 (B0X70_20335) | 4649899..4650021 | - | 123 | WP_071647067.1 | mRNA interferase | - |
B0X70_RS20130 (B0X70_20340) | 4650141..4650727 | - | 587 | Protein_3949 | hypothetical protein | - |
B0X70_RS20135 | 4651418..4651582 | - | 165 | WP_162473447.1 | hypothetical protein | - |
B0X70_RS20140 (B0X70_20345) | 4651818..4652762 | - | 945 | WP_036808642.1 | class I SAM-dependent methyltransferase | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|---|---|---|---|---|---|---|
- | inside | Prophage | - | - | 4597780..4650730 | 52950 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 108 a.a. Molecular weight: 12681.78 Da Isoelectric Point: 10.4212
>T74256 WP_217470238.1 NZ_CP020335:4647425-4647748 [Photorhabdus akhurstii]
MEYLVFIETPVFSRERAELSTDDEFRLLQEHLLKNHEQGSTISATGGCKKIRWQRERVRKRGRVRIIYYAITKTGRLYLL
LIYPKNKKDDLTPKEKEVLKAISSKLQ
MEYLVFIETPVFSRERAELSTDDEFRLLQEHLLKNHEQGSTISATGGCKKIRWQRERVRKRGRVRIIYYAITKTGRLYLL
LIYPKNKKDDLTPKEKEVLKAISSKLQ
Download Length: 324 bp
>T74256 NZ_CP020335:4647425-4647748 [Photorhabdus akhurstii]
ATGGAATATCTGGTTTTTATCGAAACTCCCGTATTTAGTAGGGAACGAGCAGAACTGTCAACCGATGATGAATTTAGGCT
ATTACAGGAGCACTTACTAAAGAATCACGAACAGGGTAGTACCATCAGCGCTACTGGAGGATGTAAAAAGATTCGCTGGC
AGCGAGAAAGAGTAAGAAAACGTGGCAGAGTAAGAATTATCTACTATGCCATAACCAAAACTGGAAGGCTCTACCTCCTT
TTGATTTACCCTAAAAATAAAAAAGATGACTTAACTCCAAAAGAAAAAGAGGTACTTAAAGCCATCAGTAGCAAATTACA
GTAA
ATGGAATATCTGGTTTTTATCGAAACTCCCGTATTTAGTAGGGAACGAGCAGAACTGTCAACCGATGATGAATTTAGGCT
ATTACAGGAGCACTTACTAAAGAATCACGAACAGGGTAGTACCATCAGCGCTACTGGAGGATGTAAAAAGATTCGCTGGC
AGCGAGAAAGAGTAAGAAAACGTGGCAGAGTAAGAATTATCTACTATGCCATAACCAAAACTGGAAGGCTCTACCTCCTT
TTGATTTACCCTAAAAATAAAAAAGATGACTTAACTCCAAAAGAAAAAGAGGTACTTAAAGCCATCAGTAGCAAATTACA
GTAA
Antitoxin
Download Length: 99 a.a. Molecular weight: 11151.79 Da Isoelectric Point: 6.2274
>AT74256 WP_113044380.1 NZ_CP020335:4647795-4648091 [Photorhabdus akhurstii]
MDKKLFNDLVESMNQMVAIEKGELSVSDENIHYHRLPDVKNLRETFGLKQSEFAEAVGVSASLIQSWEQHRRIPSGSSLK
LLKMLERNPALINELSTL
MDKKLFNDLVESMNQMVAIEKGELSVSDENIHYHRLPDVKNLRETFGLKQSEFAEAVGVSASLIQSWEQHRRIPSGSSLK
LLKMLERNPALINELSTL
Download Length: 297 bp
>AT74256 NZ_CP020335:4647795-4648091 [Photorhabdus akhurstii]
ATGGACAAAAAACTTTTTAACGATCTGGTTGAAAGCATGAATCAGATGGTAGCAATTGAAAAAGGCGAACTTTCTGTTTC
CGATGAAAATATCCATTACCATCGCCTGCCTGATGTAAAAAACTTACGTGAAACCTTTGGCTTAAAACAAAGTGAATTTG
CCGAAGCTGTTGGCGTTTCTGCATCTCTAATTCAAAGCTGGGAACAGCACCGCCGCATTCCTTCTGGTTCATCACTGAAA
CTACTTAAGATGCTTGAACGTAATCCTGCGCTCATTAATGAATTAAGCACACTTTAA
ATGGACAAAAAACTTTTTAACGATCTGGTTGAAAGCATGAATCAGATGGTAGCAATTGAAAAAGGCGAACTTTCTGTTTC
CGATGAAAATATCCATTACCATCGCCTGCCTGATGTAAAAAACTTACGTGAAACCTTTGGCTTAAAACAAAGTGAATTTG
CCGAAGCTGTTGGCGTTTCTGCATCTCTAATTCAAAGCTGGGAACAGCACCGCCGCATTCCTTCTGGTTCATCACTGAAA
CTACTTAAGATGCTTGAACGTAATCCTGCGCTCATTAATGAATTAAGCACACTTTAA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Structures
Toxin
Source | ID | Structure |
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Antitoxin
Source | ID | Structure |
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