Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) higBA (relBE)/HTH(antitoxin)
Location 4647425..4648091 Replicon chromosome
Accession NZ_CP020335
Organism Photorhabdus akhurstii strain 0813-124 phase II

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag B0X70_RS20100 Protein ID WP_217470238.1
Coordinates 4647425..4647748 (+) Length 108 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag B0X70_RS20105 Protein ID WP_113044380.1
Coordinates 4647795..4648091 (+) Length 99 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
B0X70_RS20080 (B0X70_20290) 4643439..4644095 + 657 WP_217470234.1 DUF2612 domain-containing protein -
B0X70_RS20085 (B0X70_20295) 4644082..4645452 + 1371 WP_217470235.1 phage tail protein -
B0X70_RS20090 (B0X70_20300) 4645452..4646078 + 627 WP_217470236.1 tail fiber assembly protein -
B0X70_RS25400 4646687..4647043 - 357 Protein_3942 Bro-N domain-containing protein -
B0X70_RS20100 (B0X70_20310) 4647425..4647748 + 324 WP_217470238.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
B0X70_RS20105 (B0X70_20315) 4647795..4648091 + 297 WP_113044380.1 NadS family protein Antitoxin
B0X70_RS20110 4648515..4648736 + 222 WP_217470239.1 hypothetical protein -
B0X70_RS20115 (B0X70_20325) 4648746..4649015 + 270 WP_065390442.1 helix-turn-helix transcriptional regulator -
B0X70_RS20120 (B0X70_20330) 4649384..4649794 - 411 WP_036808644.1 type II toxin-antitoxin system HicB family antitoxin -
B0X70_RS20125 (B0X70_20335) 4649899..4650021 - 123 WP_071647067.1 mRNA interferase -
B0X70_RS20130 (B0X70_20340) 4650141..4650727 - 587 Protein_3949 hypothetical protein -
B0X70_RS20135 4651418..4651582 - 165 WP_162473447.1 hypothetical protein -
B0X70_RS20140 (B0X70_20345) 4651818..4652762 - 945 WP_036808642.1 class I SAM-dependent methyltransferase -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 4597780..4650730 52950


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

(39-82)


Sequences


Toxin        


Download         Length: 108 a.a.        Molecular weight: 12681.78 Da        Isoelectric Point: 10.4212

>T74256 WP_217470238.1 NZ_CP020335:4647425-4647748 [Photorhabdus akhurstii]
MEYLVFIETPVFSRERAELSTDDEFRLLQEHLLKNHEQGSTISATGGCKKIRWQRERVRKRGRVRIIYYAITKTGRLYLL
LIYPKNKKDDLTPKEKEVLKAISSKLQ

Download         Length: 324 bp

>T74256 NZ_CP020335:4647425-4647748 [Photorhabdus akhurstii]
ATGGAATATCTGGTTTTTATCGAAACTCCCGTATTTAGTAGGGAACGAGCAGAACTGTCAACCGATGATGAATTTAGGCT
ATTACAGGAGCACTTACTAAAGAATCACGAACAGGGTAGTACCATCAGCGCTACTGGAGGATGTAAAAAGATTCGCTGGC
AGCGAGAAAGAGTAAGAAAACGTGGCAGAGTAAGAATTATCTACTATGCCATAACCAAAACTGGAAGGCTCTACCTCCTT
TTGATTTACCCTAAAAATAAAAAAGATGACTTAACTCCAAAAGAAAAAGAGGTACTTAAAGCCATCAGTAGCAAATTACA
GTAA

Antitoxin


Download         Length: 99 a.a.        Molecular weight: 11151.79 Da        Isoelectric Point: 6.2274

>AT74256 WP_113044380.1 NZ_CP020335:4647795-4648091 [Photorhabdus akhurstii]
MDKKLFNDLVESMNQMVAIEKGELSVSDENIHYHRLPDVKNLRETFGLKQSEFAEAVGVSASLIQSWEQHRRIPSGSSLK
LLKMLERNPALINELSTL

Download         Length: 297 bp

>AT74256 NZ_CP020335:4647795-4648091 [Photorhabdus akhurstii]
ATGGACAAAAAACTTTTTAACGATCTGGTTGAAAGCATGAATCAGATGGTAGCAATTGAAAAAGGCGAACTTTCTGTTTC
CGATGAAAATATCCATTACCATCGCCTGCCTGATGTAAAAAACTTACGTGAAACCTTTGGCTTAAAACAAAGTGAATTTG
CCGAAGCTGTTGGCGTTTCTGCATCTCTAATTCAAAGCTGGGAACAGCACCGCCGCATTCCTTCTGGTTCATCACTGAAA
CTACTTAAGATGCTTGAACGTAATCCTGCGCTCATTAATGAATTAAGCACACTTTAA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure


Antitoxin

Source ID Structure

References