Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/Tad-HTH_37
Location 3339071..3339599 Replicon chromosome
Accession NZ_CP020335
Organism Photorhabdus akhurstii strain 0813-124 phase II

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag B0X70_RS14395 Protein ID WP_246593297.1
Coordinates 3339071..3339301 (+) Length 77 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag B0X70_RS14400 Protein ID WP_036815231.1
Coordinates 3339291..3339599 (+) Length 103 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
B0X70_RS14375 (B0X70_14520) 3335887..3336519 + 633 WP_217469636.1 SDR family oxidoreductase -
B0X70_RS14380 (B0X70_14525) 3336564..3336881 - 318 WP_036782152.1 PTS system regulator TmaR -
B0X70_RS14385 (B0X70_14530) 3337846..3338076 + 231 WP_217469637.1 hypothetical protein -
B0X70_RS14390 (B0X70_14535) 3338276..3338500 - 225 WP_217469638.1 hypothetical protein -
B0X70_RS14395 (B0X70_14540) 3339071..3339301 + 231 WP_246593297.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
B0X70_RS14400 (B0X70_14545) 3339291..3339599 + 309 WP_036815231.1 helix-turn-helix transcriptional regulator Antitoxin
B0X70_RS14405 (B0X70_14550) 3339760..3341190 + 1431 WP_217469640.1 exodeoxyribonuclease I -
B0X70_RS14410 (B0X70_14555) 3341331..3343046 - 1716 WP_217469641.1 D-lactate dehydrogenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(2-70)

Antitoxin

Cro/C1-type helix-turn-helix domain

(44-97)


Sequences

Toxin        


Download         Length: 77 a.a.        Molecular weight: 8938.44 Da        Isoelectric Point: 10.4715

>T74251 WP_246593297.1 NZ_CP020335:3339071-3339301 [Photorhabdus akhurstii]
MREHGANLGEPHTEAFGNGLFELRLKGAEGIARVFYCTMIRHRIVMLHSFVKKTQKTPLKERRKAEIRMKEVENDW

Download         Length: 231 bp

>T74251 NZ_CP020335:3339071-3339301 [Photorhabdus akhurstii]
ATGCGAGAACATGGTGCCAACCTCGGAGAACCACACACAGAAGCGTTTGGTAATGGGTTGTTTGAACTCAGACTCAAAGG
GGCTGAAGGGATTGCTCGCGTGTTCTATTGCACAATGATTAGGCACCGTATAGTGATGCTGCACAGCTTCGTGAAGAAAA
CGCAAAAGACCCCACTTAAAGAACGCAGGAAAGCCGAAATCAGAATGAAAGAGGTAGAAAATGACTGGTAA

Antitoxin


Download         Length: 103 a.a.        Molecular weight: 11044.86 Da        Isoelectric Point: 10.2174

>AT74251 WP_036815231.1 NZ_CP020335:3339291-3339599 [Photorhabdus akhurstii]
MTGKHTPPTMTHDEMVAKMLSNPAVKAEYEKLEQEFALLDELLAARKKAGLTQAQVAERMGTKATAITRLESGLASGTQG
PSYNTLKKYAAAVGKKLQIRLV

Download         Length: 309 bp

>AT74251 NZ_CP020335:3339291-3339599 [Photorhabdus akhurstii]
ATGACTGGTAAACATACCCCTCCAACTATGACACACGATGAAATGGTTGCAAAAATGCTGTCAAATCCGGCTGTAAAAGC
TGAATACGAGAAACTGGAACAAGAATTTGCATTGCTTGATGAACTGCTAGCTGCACGCAAAAAAGCCGGGCTAACACAAG
CGCAAGTAGCTGAACGCATGGGAACCAAAGCAACGGCCATCACACGGCTTGAAAGTGGGCTAGCTTCTGGTACACAAGGG
CCTTCGTATAATACATTGAAAAAATATGCAGCAGCTGTCGGTAAAAAATTACAGATACGCCTAGTATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References