Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 829576..830123 Replicon chromosome
Accession NZ_CP020335
Organism Photorhabdus akhurstii strain 0813-124 phase II

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag B0X70_RS03575 Protein ID WP_256448183.1
Coordinates 829995..830123 (-) Length 43 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag B0X70_RS03570 Protein ID WP_217470895.1
Coordinates 829576..829998 (-) Length 141 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
B0X70_RS03545 (B0X70_03595) 824733..826979 + 2247 WP_217470893.1 phosphoenolpyruvate--protein phosphotransferase -
B0X70_RS03550 (B0X70_03600) 827055..827930 + 876 WP_036812191.1 prolipoprotein diacylglyceryl transferase -
B0X70_RS03555 (B0X70_03605) 827927..828721 + 795 WP_217470894.1 thymidylate synthase -
B0X70_RS03560 (B0X70_03610) 828847..829113 + 267 WP_110085946.1 hypothetical protein -
B0X70_RS03565 (B0X70_03615) 829110..829442 + 333 WP_052739388.1 hypothetical protein -
B0X70_RS03570 (B0X70_03620) 829576..829998 - 423 WP_217470895.1 transcriptional regulator Antitoxin
B0X70_RS03575 (B0X70_03625) 829995..830123 - 129 WP_256448183.1 type II toxin-antitoxin system HigB family toxin Toxin
B0X70_RS03580 (B0X70_03630) 830503..831018 + 516 WP_217470896.1 prepilin peptidase-dependent protein -
B0X70_RS03585 (B0X70_03635) 831186..831773 + 588 WP_217470897.1 prepilin peptidase-dependent protein -
B0X70_RS03590 (B0X70_03640) 831779..832240 + 462 WP_217470898.1 YgdB family protein -
B0X70_RS03595 (B0X70_03645) 832237..832623 + 387 WP_036812175.1 prepilin-type N-terminal cleavage/methylation domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, mRNA interferase HigB

(1-32)

Antitoxin

Antitoxin HigA

(9-140)


Sequences

Toxin        


Download         Length: 43 a.a.        Molecular weight: 5158.84 Da        Isoelectric Point: 7.1601

>T74234 WP_256448183.1 NZ_CP020335:c830123-829995 [Photorhabdus akhurstii]
IGGNNVRLLTFIEFSMEHCYIKYIVSHAEYDKLTDYYRRNRE

Download         Length: 129 bp

>T74234 NZ_CP020335:c830123-829995 [Photorhabdus akhurstii]
ATTGGTGGTAATAATGTTCGGTTACTGACCTTTATCGAATTTTCAATGGAGCACTGTTACATTAAATACATCGTATCCCA
CGCAGAATACGACAAGTTAACCGACTACTACCGGAGAAACAGAGAATGA

Antitoxin


Download         Length: 141 a.a.        Molecular weight: 15763.92 Da        Isoelectric Point: 4.2783

>AT74234 WP_217470895.1 NZ_CP020335:c829998-829576 [Photorhabdus akhurstii]
MINFAVVQERAHALFSEIPWLTYIDTSEQYKEAMDLIDELFKDYDNNKGLIEILATTIERYEDTAPEFAEFNQAIENIPT
GIATLRVLMDQYGLTPADLKNEIGEASLVSQILSGTKSLTVTHIKALSKRFKVSSAVFID

Download         Length: 423 bp

>AT74234 NZ_CP020335:c829998-829576 [Photorhabdus akhurstii]
ATGATAAATTTTGCAGTCGTTCAGGAACGAGCTCACGCTCTGTTTTCAGAGATCCCTTGGCTGACCTACATCGATACCTC
AGAACAGTACAAAGAAGCGATGGATTTAATTGATGAGCTTTTCAAAGACTATGACAACAACAAAGGGTTAATTGAGATTC
TAGCTACAACAATTGAACGCTATGAAGATACTGCCCCTGAATTTGCAGAATTTAACCAGGCTATTGAAAATATTCCTACG
GGGATTGCAACCCTACGAGTTCTAATGGATCAATACGGTCTTACGCCAGCCGACCTTAAAAACGAAATCGGAGAAGCTTC
TCTGGTATCACAAATTCTGAGTGGAACAAAGTCACTGACAGTAACCCATATAAAAGCCCTGAGTAAACGTTTTAAGGTTT
CTAGTGCAGTTTTTATCGATTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References