Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/Tad-HTH_37
Location 289278..289873 Replicon chromosome
Accession NZ_CP020335
Organism Photorhabdus akhurstii strain 0813-124 phase II

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag B0X70_RS01260 Protein ID WP_217470701.1
Coordinates 289553..289873 (-) Length 107 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag B0X70_RS01255 Protein ID WP_217470700.1
Coordinates 289278..289556 (-) Length 93 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
B0X70_RS01240 (B0X70_01245) 285632..286327 - 696 WP_217470698.1 hypothetical protein -
B0X70_RS01245 (B0X70_01250) 286937..288250 - 1314 WP_217470699.1 hypothetical protein -
B0X70_RS01250 (B0X70_01255) 288923..289249 - 327 WP_256448178.1 KilA-N domain-containing protein -
B0X70_RS01255 (B0X70_01260) 289278..289556 - 279 WP_217470700.1 helix-turn-helix transcriptional regulator Antitoxin
B0X70_RS01260 (B0X70_01265) 289553..289873 - 321 WP_217470701.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
B0X70_RS01265 (B0X70_01270) 290377..290649 - 273 WP_046397880.1 type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family -
B0X70_RS01270 (B0X70_01275) 290649..291089 - 441 WP_046397879.1 hypothetical protein -
B0X70_RS01275 (B0X70_01280) 291527..291781 + 255 WP_046397878.1 hypothetical protein -
B0X70_RS01280 (B0X70_01290) 292004..292261 - 258 WP_246593409.1 helix-turn-helix transcriptional regulator -
B0X70_RS01285 (B0X70_01295) 292287..293171 + 885 WP_217470702.1 IS982 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 292287..293171 884


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(15-102)

Antitoxin

Cro/C1-type helix-turn-helix domain

(37-85)


Sequences

Toxin        


Download         Length: 107 a.a.        Molecular weight: 12291.54 Da        Isoelectric Point: 9.9270

>T74232 WP_217470701.1 NZ_CP020335:c289873-289553 [Photorhabdus akhurstii]
MNWNVELYDGVEDAILNMPPRIQARMLKLLELIEEYGANLGEPHTKSMGKGLFEIRAKAQEGIGRRLFCYLQGPNIIVLH
AFIKKNQKIFKKDLDLAYKRMKEVTK

Download         Length: 321 bp

>T74232 NZ_CP020335:c289873-289553 [Photorhabdus akhurstii]
ATGAACTGGAACGTTGAACTCTACGATGGTGTCGAGGATGCGATCCTCAATATGCCACCCAGAATTCAAGCTCGTATGCT
GAAACTACTTGAACTCATTGAAGAATATGGCGCTAATCTTGGAGAGCCACACACTAAGTCAATGGGAAAAGGTCTATTCG
AGATTCGAGCCAAAGCGCAAGAAGGTATTGGACGCAGATTGTTTTGTTACCTACAAGGCCCAAATATCATCGTCCTTCAT
GCGTTTATTAAGAAAAACCAGAAGATATTTAAAAAGGATCTTGATCTCGCTTATAAACGAATGAAAGAGGTTACAAAATG
A

Antitoxin


Download         Length: 93 a.a.        Molecular weight: 10237.82 Da        Isoelectric Point: 10.1795

>AT74232 WP_217470700.1 NZ_CP020335:c289556-289278 [Photorhabdus akhurstii]
MNSLKSLKSKALSNPDVKAEYDALKPEFELINTLLRMRHAAGLTQNQVAQRMGTKEANISRLEKGNGNPTLKTLLNYAKA
CNCELHFGFKTT

Download         Length: 279 bp

>AT74232 NZ_CP020335:c289556-289278 [Photorhabdus akhurstii]
ATGAATAGTTTAAAGTCGCTAAAATCCAAAGCATTATCTAACCCAGATGTAAAAGCTGAGTATGATGCGCTAAAACCAGA
ATTCGAGCTAATTAATACTCTATTACGCATGCGGCATGCTGCTGGTTTAACTCAAAACCAAGTTGCCCAGCGTATGGGAA
CAAAAGAAGCGAATATTTCCAGGCTTGAAAAAGGAAATGGAAACCCAACACTTAAGACATTATTGAACTACGCCAAAGCT
TGCAATTGTGAACTACATTTTGGCTTCAAAACAACTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References