Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 111331..112058 Replicon chromosome
Accession NZ_CP020335
Organism Photorhabdus akhurstii strain 0813-124 phase II

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag B0X70_RS00535 Protein ID WP_217471636.1
Coordinates 111747..112058 (-) Length 104 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag B0X70_RS00530 Protein ID WP_217470640.1
Coordinates 111331..111750 (-) Length 140 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
B0X70_RS00520 (B0X70_00520) 109725..110921 + 1197 WP_217470639.1 DUF2220 family protein -
B0X70_RS00525 (B0X70_00525) 110972..111334 - 363 WP_246593394.1 LysR substrate-binding domain-containing protein -
B0X70_RS00530 (B0X70_00530) 111331..111750 - 420 WP_217470640.1 helix-turn-helix domain-containing protein Antitoxin
B0X70_RS00535 (B0X70_00535) 111747..112058 - 312 WP_217471636.1 type II toxin-antitoxin system HigB family toxin Toxin
B0X70_RS00540 (B0X70_00540) 112272..112931 + 660 WP_036812597.1 carbonic anhydrase -
B0X70_RS00545 (B0X70_00545) 112959..113429 + 471 WP_036812599.1 cyanase -
B0X70_RS00550 (B0X70_00550) 113508..115022 - 1515 WP_246593395.1 NAD(P)/FAD-dependent oxidoreductase -
B0X70_RS00555 (B0X70_00555) 115046..115921 - 876 WP_217470641.1 alpha/beta hydrolase -
B0X70_RS00560 (B0X70_00560) 116559..117056 + 498 WP_040149946.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, mRNA interferase HigB

(21-93)

Antitoxin

Cro/C1-type helix-turn-helix domain

(84-138)


Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 12311.03 Da        Isoelectric Point: 8.3828

>T74230 WP_217471636.1 NZ_CP020335:c112058-111747 [Photorhabdus akhurstii]
MHVISKDPFEKAARDFPNDADAIIATYKQLKEKDFENPVELRSQFPSLDNFKYRDKWWVIDIGGQNLRMIAYINFVNKLL
YINHIATHAEYNKLTKQYRETKE

Download         Length: 312 bp

>T74230 NZ_CP020335:c112058-111747 [Photorhabdus akhurstii]
ATGCACGTTATTTCCAAAGATCCATTTGAGAAAGCTGCTCGCGATTTCCCAAATGATGCAGATGCAATTATTGCAACGTA
TAAGCAGTTAAAAGAAAAAGATTTTGAGAACCCTGTGGAATTACGAAGTCAGTTCCCCAGTCTTGATAATTTCAAGTACA
GAGACAAATGGTGGGTAATAGACATAGGTGGGCAAAACTTACGAATGATCGCCTATATAAATTTCGTTAATAAACTCCTA
TATATCAATCATATAGCCACTCATGCAGAATATAACAAATTAACTAAGCAGTATCGGGAGACGAAAGAATGA

Antitoxin


Download         Length: 140 a.a.        Molecular weight: 15396.63 Da        Isoelectric Point: 4.6382

>AT74230 WP_217470640.1 NZ_CP020335:c111750-111331 [Photorhabdus akhurstii]
MIAEPTKALEATKVLVAAVPFLGSCTSEDAYNDALAMVDYLIEHDDENPLIDFLATKIAEYENNNERFAAFNKAVDDIPT
GVAALRVLMDQYRLSYSDLKEEIGSKSLVSQILSGKRSLTIAHIKALSKRFNVKPDLFL

Download         Length: 420 bp

>AT74230 NZ_CP020335:c111750-111331 [Photorhabdus akhurstii]
ATGATTGCAGAACCTACCAAAGCACTTGAAGCCACAAAGGTACTGGTAGCCGCTGTTCCCTTCTTAGGGAGCTGCACTTC
CGAGGATGCCTATAATGACGCGCTGGCAATGGTGGATTACCTCATTGAGCACGATGATGAAAATCCACTGATTGACTTTC
TAGCCACTAAAATCGCTGAGTATGAAAACAACAATGAACGCTTTGCTGCATTTAATAAAGCAGTGGATGACATACCAACC
GGTGTAGCAGCGCTGCGTGTGTTGATGGATCAATACAGGCTCTCTTACTCAGACCTGAAAGAAGAAATTGGCTCCAAATC
ACTTGTCAGCCAGATTCTATCTGGTAAGCGCTCATTAACGATTGCGCATATTAAAGCGCTTTCCAAGCGCTTCAACGTAA
AGCCGGATCTATTTCTGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References