Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 459502..460132 Replicon chromosome
Accession NZ_CP020114
Organism Nodularia spumigena UHCC 0039

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag BMF81_RS02115 Protein ID WP_199912102.1
Coordinates 459502..459828 (+) Length 109 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag BMF81_RS02120 Protein ID WP_006194256.1
Coordinates 459839..460132 (+) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BMF81_RS02050 454617..454832 - 216 WP_063872043.1 hypothetical protein -
BMF81_RS02055 455038..455280 + 243 WP_006197345.1 hypothetical protein -
BMF81_RS02060 455286..455546 + 261 WP_006197346.1 type II toxin-antitoxin system RelE/ParE family toxin -
BMF81_RS02065 455643..456059 - 417 WP_006197347.1 PIN domain-containing protein -
BMF81_RS02070 456056..456325 - 270 WP_017803781.1 hypothetical protein -
BMF81_RS02075 456432..456959 - 528 WP_006197349.1 GUN4 domain-containing protein -
BMF81_RS02080 457069..457416 - 348 WP_107805828.1 type II toxin-antitoxin system PemK/MazF family toxin -
BMF81_RS02085 457398..457619 - 222 WP_017803783.1 ribbon-helix-helix domain-containing protein -
BMF81_RS02090 457688..458089 - 402 WP_006199367.1 type II toxin-antitoxin system VapC family toxin -
BMF81_RS02095 458086..458373 - 288 WP_006199366.1 DUF2281 domain-containing protein -
BMF81_RS02100 458612..458830 - 219 WP_017803784.1 type II toxin-antitoxin system HicA family toxin -
BMF81_RS02105 458831..459127 - 297 WP_006194259.1 type II toxin-antitoxin system HicB family antitoxin -
BMF81_RS02110 459093..459356 - 264 WP_006194258.1 type II toxin-antitoxin system ParD family antitoxin -
BMF81_RS02115 459502..459828 + 327 WP_199912102.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
BMF81_RS02120 459839..460132 + 294 WP_006194256.1 HigA family addiction module antidote protein Antitoxin
BMF81_RS02125 460367..460819 + 453 WP_107805829.1 hypothetical protein -
BMF81_RS02130 460881..461462 + 582 WP_107805830.1 hypothetical protein -
BMF81_RS02135 461601..463805 - 2205 WP_107805831.1 transketolase -
BMF81_RS02140 464400..464657 + 258 WP_006194249.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(16-108)

Antitoxin

Cro/C1-type helix-turn-helix domain

(16-68)


Sequences

Toxin        


Download         Length: 109 a.a.        Molecular weight: 12532.21 Da        Isoelectric Point: 6.0764

>T74173 WP_199912102.1 NZ_CP020114:459502-459828 [Nodularia spumigena UHCC 0039]
MTSVTLWVTIIIVIVIMIRNFKHKGLRKLFEDDNRSGVNPNHAEKLLDLLDRLDAASVAEDMNFPGSKFHQLIRNRKGEY
SVTVSGNWRLTFVFEDGDAYDVNYEDYH

Download         Length: 327 bp

>T74173 NZ_CP020114:459502-459828 [Nodularia spumigena UHCC 0039]
TTGACAAGTGTAACCTTATGGGTTACAATAATAATTGTTATTGTAATTATGATCAGAAATTTCAAGCATAAGGGGTTAAG
AAAGCTGTTTGAAGATGATAATAGAAGTGGGGTTAATCCAAATCATGCTGAAAAACTGTTAGATTTATTAGATAGACTAG
ATGCTGCATCTGTAGCTGAGGATATGAATTTTCCTGGCTCTAAGTTTCATCAATTAATAAGGAATAGGAAAGGTGAATAT
TCAGTTACAGTTTCTGGTAATTGGCGTTTAACTTTTGTTTTTGAAGATGGGGATGCTTACGACGTAAATTACGAGGATTA
TCATTAG

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11112.77 Da        Isoelectric Point: 9.1191

>AT74173 WP_006194256.1 NZ_CP020114:459839-460132 [Nodularia spumigena UHCC 0039]
MNTNRKPRHPGALIKRQYLEPLNITVTELANILGVSRKTVSEIVNERASVTPNIALRLANAFQTTPELWLNLQQKFDLWC
AKNESEEWKNISPIEIS

Download         Length: 294 bp

>AT74173 NZ_CP020114:459839-460132 [Nodularia spumigena UHCC 0039]
ATGAATACTAACAGAAAACCTAGACATCCTGGTGCTTTGATTAAACGTCAATATTTAGAACCTTTAAATATAACGGTGAC
AGAACTTGCTAATATTTTGGGTGTGTCTCGAAAAACGGTTTCGGAAATTGTGAATGAACGTGCAAGTGTAACACCTAATA
TTGCTTTGCGGTTAGCAAATGCTTTTCAAACTACGCCGGAACTTTGGTTAAATCTTCAGCAGAAATTTGACCTCTGGTGT
GCAAAAAATGAGTCTGAAGAATGGAAAAATATCTCACCTATTGAAATTAGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References