Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-YefM
Location 2068861..2069363 Replicon chromosome
Accession NZ_CP020107
Organism Escherichia coli strain 13E0767

Toxin (Protein)


Gene name yoeB Uniprot ID U9YDH0
Locus tag EC767_RS10335 Protein ID WP_000767829.1
Coordinates 2069109..2069363 (+) Length 85 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID S1Q063
Locus tag EC767_RS10330 Protein ID WP_001259255.1
Coordinates 2068861..2069112 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EC767_RS10300 2064039..2065106 - 1068 WP_001695908.1 bifunctional histidinol-phosphatase/imidazoleglycerol-phosphate dehydratase HisB -
EC767_RS10305 2065106..2066176 - 1071 WP_001099214.1 histidinol-phosphate transaminase -
EC767_RS10310 2066173..2067477 - 1305 WP_001358504.1 histidinol dehydrogenase -
EC767_RS10315 2067483..2068382 - 900 WP_000131792.1 ATP phosphoribosyltransferase -
EC767_RS10325 2068528..2068578 - 51 WP_001364200.1 his operon leader peptide -
EC767_RS10330 2068861..2069112 + 252 WP_001259255.1 YoeB-YefM toxin-antitoxin system antitoxin YefM Antitoxin
EC767_RS10335 2069109..2069363 + 255 WP_000767829.1 type II toxin-antitoxin system mRNA interferase toxin YoeB Toxin
EC767_RS10340 2069446..2070270 + 825 WP_000754758.1 SDR family oxidoreductase -
EC767_RS10345 2070316..2071245 + 930 WP_000803351.1 LysR family transcriptional regulator -
EC767_RS25845 2071460..2071522 + 63 WP_010723108.1 membrane protein YoeI -
EC767_RS10350 2071512..2072870 + 1359 WP_000019197.1 putrescine/proton symporter PlaP -
EC767_RS10355 2073049..2074107 + 1059 WP_000492340.1 transport protein YeeE -
EC767_RS10360 2074121..2074348 + 228 WP_000985273.1 sulfurtransferase TusA family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(2-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-73)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 10183.58 Da        Isoelectric Point: 8.0353

>T74136 WP_000767829.1 NZ_CP020107:2069109-2069363 [Escherichia coli]
VKLIWSEESWDDYLYWQETDKRIVKKINELIKDTRRTPFEGKGKPEPLKHNLSGFWSRRITEEHRLVYAVTDDSLLIAAC
RYHY

Download         Length: 255 bp

>T74136 NZ_CP020107:2069109-2069363 [Escherichia coli]
GTGAAACTAATCTGGTCTGAGGAATCATGGGATGATTATCTGTACTGGCAGGAAACAGATAAGCGAATTGTTAAAAAGAT
CAATGAACTTATCAAAGATACCCGCAGAACGCCATTTGAAGGTAAGGGGAAGCCAGAACCCCTGAAACATAATTTGTCAG
GTTTCTGGTCCCGACGCATTACAGAGGAGCACCGTCTGGTATACGCGGTTACCGACGATTCACTGCTCATTGCAGCATGT
CGTTATCATTATTGA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9307.58 Da        Isoelectric Point: 4.7954

>AT74136 WP_001259255.1 NZ_CP020107:2068861-2069112 [Escherichia coli]
MRTISYSEARQNLSATMMKAVEDHAPILITRQNGEACVLMSLEEYNSLEETAYLLRSPANARRLMDSIDSLKSGKGTEKD
IIE

Download         Length: 252 bp

>AT74136 NZ_CP020107:2068861-2069112 [Escherichia coli]
ATGCGTACAATTAGCTACAGCGAAGCGCGTCAGAATTTGTCGGCAACAATGATGAAAGCCGTTGAAGATCATGCCCCGAT
CCTTATTACTCGTCAGAATGGAGAGGCTTGTGTTCTGATGTCACTCGAAGAATACAACTCGCTGGAAGAGACGGCTTATC
TACTGCGCTCCCCCGCTAACGCCCGGAGATTGATGGACTCAATCGATAGCCTGAAATCAGGCAAAGGAACAGAAAAGGAC
ATTATTGAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6NY6
PDB 2A6S
PDB 6OXA
PDB 2A6R
PDB 4V8X
PDB 6OTR
PDB 6OXI
PDB 2A6Q

Antitoxin

Source ID Structure
PDB 2A6Q
AlphaFold DB A0A7U9LNR0

References