74108

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-YefM
Location 2175944..2176446 Replicon chromosome
Accession NZ_CP020106
Organism Escherichia coli strain 13E0780

Toxin (Protein)


Gene name yoeB Uniprot ID U9YDH0
Locus tag EC780_RS11490 Protein ID WP_000767829.1
Coordinates 2176192..2176446 (+) Length 85 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID S1Q063
Locus tag EC780_RS11485 Protein ID WP_001259255.1
Coordinates 2175944..2176195 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EC780_RS11455 2171121..2172188 - 1068 WP_000080093.1 bifunctional histidinol-phosphatase/imidazoleglycerol-phosphate dehydratase HisB -
EC780_RS11460 2172188..2173258 - 1071 WP_000108962.1 histidinol-phosphate transaminase -
EC780_RS11465 2173255..2174559 - 1305 WP_001397240.1 histidinol dehydrogenase -
EC780_RS11470 2174565..2175464 - 900 WP_000131782.1 ATP phosphoribosyltransferase -
EC780_RS11480 2175610..2175660 - 51 WP_001364200.1 his operon leader peptide -
EC780_RS11485 2175944..2176195 + 252 WP_001259255.1 YoeB-YefM toxin-antitoxin system antitoxin YefM Antitoxin
EC780_RS11490 2176192..2176446 + 255 WP_000767829.1 type II toxin-antitoxin system mRNA interferase toxin YoeB Toxin
EC780_RS11495 2176529..2177353 + 825 WP_000754752.1 SDR family oxidoreductase -
EC780_RS11500 2177399..2178328 + 930 WP_000803351.1 LysR family transcriptional regulator -
EC780_RS29090 2178543..2178605 + 63 WP_010723108.1 membrane protein YoeI -
EC780_RS11505 2178595..2179953 + 1359 WP_000019197.1 putrescine/proton symporter PlaP -
EC780_RS11510 2180132..2181190 + 1059 WP_000492346.1 transport protein YeeE -
EC780_RS11515 2181204..2181431 + 228 WP_000985273.1 sulfurtransferase TusA family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(2-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-73)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 10183.58 Da        Isoelectric Point: 8.0353

>T74108 WP_000767829.1 NZ_CP020106:2176192-2176446 [Escherichia coli]
VKLIWSEESWDDYLYWQETDKRIVKKINELIKDTRRTPFEGKGKPEPLKHNLSGFWSRRITEEHRLVYAVTDDSLLIAAC
RYHY

Download         Length: 255 bp

>T74108 NZ_CP020106:2176192-2176446 [Escherichia coli]
GTGAAACTAATCTGGTCTGAGGAATCATGGGACGATTATCTGTACTGGCAGGAAACAGATAAGCGAATTGTTAAAAAGAT
CAATGAACTTATCAAAGATACCCGCAGAACGCCATTTGAAGGTAAGGGGAAGCCAGAACCCCTGAAACATAATTTGTCAG
GTTTCTGGTCCCGACGCATTACAGAGGAGCACCGTCTGGTATACGCGGTTACCGACGATTCACTGCTCATTGCAGCATGT
CGTTATCATTATTGA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9307.58 Da        Isoelectric Point: 4.7954

>AT74108 WP_001259255.1 NZ_CP020106:2175944-2176195 [Escherichia coli]
MRTISYSEARQNLSATMMKAVEDHAPILITRQNGEACVLMSLEEYNSLEETAYLLRSPANARRLMDSIDSLKSGKGTEKD
IIE

Download         Length: 252 bp

>AT74108 NZ_CP020106:2175944-2176195 [Escherichia coli]
ATGCGTACAATTAGCTACAGCGAAGCGCGTCAGAATTTGTCGGCAACAATGATGAAAGCCGTTGAAGATCATGCCCCGAT
CCTTATTACTCGTCAGAATGGAGAGGCTTGTGTTCTGATGTCACTCGAAGAATATAACTCCCTGGAAGAGACGGCTTATC
TACTGCGTTCCCCCGCTAACGCCCGGAGATTGATGGACTCAATCGATAGCCTGAAATCAGGCAAAGGAACGGAAAAGGAC
ATCATTGAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6NY6
PDB 2A6S
PDB 6OXA
PDB 2A6R
PDB 4V8X
PDB 6OTR
PDB 6OXI
PDB 2A6Q

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9LNR0

References