Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-YefM
Location 2175944..2176446 Replicon chromosome
Accession NZ_CP020106
Organism Escherichia coli strain 13E0780

Toxin (Protein)


Gene name yoeB Uniprot ID U9YDH0
Locus tag EC780_RS11490 Protein ID WP_000767829.1
Coordinates 2176192..2176446 (+) Length 85 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID S1Q063
Locus tag EC780_RS11485 Protein ID WP_001259255.1
Coordinates 2175944..2176195 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EC780_RS11455 2171121..2172188 - 1068 WP_000080093.1 bifunctional histidinol-phosphatase/imidazoleglycerol-phosphate dehydratase HisB -
EC780_RS11460 2172188..2173258 - 1071 WP_000108962.1 histidinol-phosphate transaminase -
EC780_RS11465 2173255..2174559 - 1305 WP_001397240.1 histidinol dehydrogenase -
EC780_RS11470 2174565..2175464 - 900 WP_000131782.1 ATP phosphoribosyltransferase -
EC780_RS11480 2175610..2175660 - 51 WP_001364200.1 his operon leader peptide -
EC780_RS11485 2175944..2176195 + 252 WP_001259255.1 YoeB-YefM toxin-antitoxin system antitoxin YefM Antitoxin
EC780_RS11490 2176192..2176446 + 255 WP_000767829.1 type II toxin-antitoxin system mRNA interferase toxin YoeB Toxin
EC780_RS11495 2176529..2177353 + 825 WP_000754752.1 SDR family oxidoreductase -
EC780_RS11500 2177399..2178328 + 930 WP_000803351.1 LysR family transcriptional regulator -
EC780_RS29090 2178543..2178605 + 63 WP_010723108.1 membrane protein YoeI -
EC780_RS11505 2178595..2179953 + 1359 WP_000019197.1 putrescine/proton symporter PlaP -
EC780_RS11510 2180132..2181190 + 1059 WP_000492346.1 transport protein YeeE -
EC780_RS11515 2181204..2181431 + 228 WP_000985273.1 sulfurtransferase TusA family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(2-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-73)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 10183.58 Da        Isoelectric Point: 8.0353

>T74108 WP_000767829.1 NZ_CP020106:2176192-2176446 [Escherichia coli]
VKLIWSEESWDDYLYWQETDKRIVKKINELIKDTRRTPFEGKGKPEPLKHNLSGFWSRRITEEHRLVYAVTDDSLLIAAC
RYHY

Download         Length: 255 bp

>T74108 NZ_CP020106:2176192-2176446 [Escherichia coli]
GTGAAACTAATCTGGTCTGAGGAATCATGGGACGATTATCTGTACTGGCAGGAAACAGATAAGCGAATTGTTAAAAAGAT
CAATGAACTTATCAAAGATACCCGCAGAACGCCATTTGAAGGTAAGGGGAAGCCAGAACCCCTGAAACATAATTTGTCAG
GTTTCTGGTCCCGACGCATTACAGAGGAGCACCGTCTGGTATACGCGGTTACCGACGATTCACTGCTCATTGCAGCATGT
CGTTATCATTATTGA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9307.58 Da        Isoelectric Point: 4.7954

>AT74108 WP_001259255.1 NZ_CP020106:2175944-2176195 [Escherichia coli]
MRTISYSEARQNLSATMMKAVEDHAPILITRQNGEACVLMSLEEYNSLEETAYLLRSPANARRLMDSIDSLKSGKGTEKD
IIE

Download         Length: 252 bp

>AT74108 NZ_CP020106:2175944-2176195 [Escherichia coli]
ATGCGTACAATTAGCTACAGCGAAGCGCGTCAGAATTTGTCGGCAACAATGATGAAAGCCGTTGAAGATCATGCCCCGAT
CCTTATTACTCGTCAGAATGGAGAGGCTTGTGTTCTGATGTCACTCGAAGAATATAACTCCCTGGAAGAGACGGCTTATC
TACTGCGTTCCCCCGCTAACGCCCGGAGATTGATGGACTCAATCGATAGCCTGAAATCAGGCAAAGGAACGGAAAAGGAC
ATCATTGAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6NY6
PDB 2A6S
PDB 6OXA
PDB 2A6R
PDB 4V8X
PDB 6OTR
PDB 6OXI
PDB 2A6Q

Antitoxin

Source ID Structure
PDB 2A6Q
AlphaFold DB A0A7U9LNR0

References