Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/RelE-HTH
Location 1695070..1695713 Replicon chromosome
Accession NZ_CP020085
Organism Glaesserella parasuis strain CL120103

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag B4X03_RS08135 Protein ID WP_021113598.1
Coordinates 1695369..1695713 (-) Length 115 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag B4X03_RS08130 Protein ID WP_021113597.1
Coordinates 1695070..1695366 (-) Length 99 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
B4X03_RS08110 1691465..1692091 - 627 WP_021113593.1 23S rRNA (uridine(2552)-2'-O)-methyltransferase RlmE -
B4X03_RS08115 1692404..1693192 + 789 WP_021113594.1 SDR family oxidoreductase -
B4X03_RS08120 1693305..1693727 - 423 WP_043896507.1 helix-turn-helix transcriptional regulator -
B4X03_RS08125 1693874..1694938 + 1065 WP_080651477.1 DUF3944 domain-containing protein -
B4X03_RS08130 1695070..1695366 - 297 WP_021113597.1 NadS family protein Antitoxin
B4X03_RS08135 1695369..1695713 - 345 WP_021113598.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
B4X03_RS08140 1695928..1697907 + 1980 WP_021113599.1 exoribonuclease II -
B4X03_RS08145 1698017..1699108 + 1092 WP_016527807.1 murein transglycosylase A -
B4X03_RS08150 1699291..1699887 - 597 WP_021113600.1 DedA family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-2

(51-111)

Antitoxin

Cro/C1-type helix-turn-helix domain

(39-76)


Sequences

Toxin        


Download         Length: 115 a.a.        Molecular weight: 13277.25 Da        Isoelectric Point: 5.9233

>T73998 WP_021113598.1 NZ_CP020085:c1695713-1695369 [Glaesserella parasuis]
METEEYLTFIETKIFEEDRKALMSDDEYQKFQAYLLESHELGDFIQNTGGCQKIRWKLESNNKGKSGGVRVIYYVVTKQG
KLLLMMMYAKSKQDNMSDKQKAMLKAVVSQLSEE

Download         Length: 345 bp

>T73998 NZ_CP020085:c1695713-1695369 [Glaesserella parasuis]
ATGGAAACAGAAGAATATCTTACTTTTATTGAAACCAAAATCTTTGAAGAAGACCGAAAAGCATTGATGTCTGATGATGA
ATATCAGAAATTTCAGGCTTATTTATTAGAATCTCACGAATTAGGCGATTTTATTCAGAATACGGGTGGTTGCCAAAAAA
TTCGCTGGAAACTAGAAAGTAATAACAAGGGCAAAAGTGGTGGTGTAAGGGTGATTTACTATGTTGTAACCAAACAGGGA
AAATTATTATTAATGATGATGTATGCTAAAAGCAAACAAGACAATATGAGTGATAAACAAAAAGCAATGTTAAAAGCGGT
TGTATCCCAATTAAGTGAGGAGTAA

Antitoxin


Download         Length: 99 a.a.        Molecular weight: 11236.18 Da        Isoelectric Point: 10.0887

>AT73998 WP_021113597.1 NZ_CP020085:c1695366-1695070 [Glaesserella parasuis]
MEKELFERLMESAREMVAIEKGEIEVPPHRIHIHKIPNVKAIRIQHQMKQAEFASLLGVSQNLVQSWEIGRRTPNGAARK
LLAIIEQQPNLVPVLQNL

Download         Length: 297 bp

>AT73998 NZ_CP020085:c1695366-1695070 [Glaesserella parasuis]
ATGGAAAAAGAACTTTTTGAACGTCTAATGGAAAGTGCGAGAGAAATGGTCGCCATTGAAAAAGGCGAAATAGAAGTACC
ACCGCATCGTATTCATATCCATAAAATCCCGAATGTCAAAGCGATTAGAATCCAGCACCAGATGAAACAAGCGGAATTTG
CTTCCCTTTTAGGCGTAAGCCAAAATCTTGTGCAGTCGTGGGAAATCGGCAGACGAACCCCAAATGGTGCGGCACGGAAA
TTGCTTGCGATCATTGAGCAACAGCCTAATCTTGTTCCAGTGCTTCAGAATTTGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References