Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/MqsA(antitoxin)
Location 941972..942621 Replicon chromosome
Accession NZ_CP020085
Organism Glaesserella parasuis strain CL120103

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag B4X03_RS11515 Protein ID WP_021119412.1
Coordinates 942421..942621 (-) Length 67 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag B4X03_RS04740 Protein ID WP_005710405.1
Coordinates 941972..942280 (-) Length 103 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
B4X03_RS04720 938446..938934 - 489 WP_005710400.1 transcription elongation factor GreB -
B4X03_RS04725 938934..939869 - 936 WP_005710401.1 KpsF/GutQ family sugar-phosphate isomerase -
B4X03_RS04730 939930..940511 - 582 WP_021110392.1 type IV pilus biogenesis/stability protein PilW -
B4X03_RS04735 940611..941771 - 1161 WP_005710403.1 bifunctional tRNA (adenosine(37)-C2)-methyltransferase TrmG/ribosomal RNA large subunit methyltransferase RlmN -
B4X03_RS04740 941972..942280 - 309 WP_005710405.1 helix-turn-helix domain-containing protein Antitoxin
B4X03_RS11515 942421..942621 - 201 WP_021119412.1 hypothetical protein Toxin
B4X03_RS04770 943456..944895 + 1440 WP_082259141.1 glutamate--tRNA ligase -
B4X03_RS04780 945362..945628 - 267 Protein_911 cation-transporting ATPase PacS -
B4X03_RS04785 945583..946517 - 935 Protein_912 IS256 family transposase -
B4X03_RS04790 946657..947031 - 375 WP_082259142.1 cytochrome b562 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - msbA 899345..950959 51614
- flank IS/Tn - - 945978..946517 539


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(41-86)


Sequences

Toxin        


Download         Length: 67 a.a.        Molecular weight: 7766.00 Da        Isoelectric Point: 5.1231

>T73993 WP_021119412.1 NZ_CP020085:c942621-942421 [Glaesserella parasuis]
MNVAFVELPPFEEYRKKYLDDDTFRLLQNELLKFPDKGELIQGTGGLRKLRIVDIIRQKEKEAELG

Download         Length: 201 bp

>T73993 NZ_CP020085:c942621-942421 [Glaesserella parasuis]
ATGAATGTCGCTTTTGTGGAGTTGCCCCCTTTTGAGGAATATAGAAAAAAGTATCTTGACGATGACACATTTAGATTATT
ACAAAATGAGTTATTAAAATTTCCCGATAAGGGAGAGCTTATTCAAGGTACTGGGGGACTAAGAAAATTGCGTATTGTGG
ATATTATTAGACAAAAGGAAAAAGAGGCGGAGCTAGGGTAA

Antitoxin


Download         Length: 103 a.a.        Molecular weight: 11539.61 Da        Isoelectric Point: 10.2919

>AT73993 WP_005710405.1 NZ_CP020085:c942280-941972 [Glaesserella parasuis]
MGKLFNELMEGMQALELHLQGKITLKTTVVEVPDPIVITPEEVKAIRQKLNLSQAVFARKLHTSVRTYQGWEQGRTKPNP
QAVLLLKMVEKSPKTFEQIASI

Download         Length: 309 bp

>AT73993 NZ_CP020085:c942280-941972 [Glaesserella parasuis]
ATGGGAAAATTATTTAATGAACTAATGGAAGGGATGCAAGCATTAGAGTTACACTTACAAGGCAAAATTACACTAAAAAC
CACTGTTGTGGAAGTTCCTGATCCGATAGTGATTACCCCCGAAGAAGTGAAAGCTATTCGTCAGAAATTAAATCTTTCAC
AAGCCGTTTTTGCTCGTAAATTACACACTTCGGTGAGAACTTATCAAGGCTGGGAGCAAGGAAGAACAAAACCTAATCCA
CAAGCGGTTTTATTATTAAAAATGGTTGAAAAATCACCAAAAACATTTGAGCAGATTGCGAGCATTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References