Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) prlF-yhaV (relBE)/YhaV-PrlF
Location 3592440..3593239 Replicon chromosome
Accession NZ_CP020058
Organism Escherichia coli strain AR_0061

Toxin (Protein)


Gene name yhaV Uniprot ID S1NYM6
Locus tag AM440_RS18470 Protein ID WP_000347251.1
Coordinates 3592440..3592904 (-) Length 155 a.a.

Antitoxin (Protein)


Gene name prlF Uniprot ID D6JF08
Locus tag AM440_RS18475 Protein ID WP_001308975.1
Coordinates 3592904..3593239 (-) Length 112 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AM440_RS18435 3587441..3587875 - 435 WP_000948824.1 PTS sugar transporter subunit IIA -
AM440_RS18440 3587893..3588771 - 879 WP_001300474.1 PTS system mannose/fructose/sorbose family transporter subunit IID -
AM440_RS18445 3588761..3589540 - 780 WP_000406214.1 PTS mannose/fructose/sorbose/N-acetylgalactosamine transporter subunit IIC -
AM440_RS18450 3589551..3590024 - 474 WP_001295547.1 PTS N-acetylgalactosamine transporter subunit IIB -
AM440_RS18455 3590047..3591327 - 1281 WP_000681920.1 tagatose-bisphosphate aldolase subunit KbaZ -
AM440_RS18465 3591576..3592385 + 810 WP_080025680.1 aga operon transcriptional regulator AgaR -
AM440_RS18470 3592440..3592904 - 465 WP_000347251.1 type II toxin-antitoxin system ribonuclease toxin YhaV Toxin
AM440_RS18475 3592904..3593239 - 336 WP_001308975.1 type II toxin-antitoxin system antitoxin PrlF Antitoxin
AM440_RS18480 3593388..3594959 - 1572 WP_032181387.1 galactarate dehydratase -
AM440_RS18485 3595334..3596668 + 1335 WP_000599636.1 galactarate/glucarate/glycerate transporter GarP -
AM440_RS18490 3596684..3597454 + 771 WP_001058209.1 2-dehydro-3-deoxyglucarate aldolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin endonuclease, YhaV

(12-150)

Antitoxin

PrlF antitoxin

(14-110)


Sequences

Toxin        


Download         Length: 155 a.a.        Molecular weight: 17777.14 Da        Isoelectric Point: 9.4947

>T73914 WP_000347251.1 NZ_CP020058:c3592904-3592440 [Escherichia coli]
MDFPQRVNGWALYAHPCFQETYDALVAEVEALKGKDPENYQRKAATKLLAVVHKVIEEHITVNPSSPAFRHGKSLGSGKN
KDWSRVKFGAGRYRLFFRYSEKEKVIILGWMNDENTLRTYGKKTDAYTVFSKMLKRGHPPADWESLTQETEENH

Download         Length: 465 bp

>T73914 NZ_CP020058:c3592904-3592440 [Escherichia coli]
ATGGATTTTCCACAAAGGGTTAATGGTTGGGCGCTATATGCTCATCCCTGTTTTCAGGAAACCTACGATGCTTTAGTTGC
CGAAGTCGAGGCATTAAAGGGAAAAGATCCTGAAAATTATCAGAGAAAAGCTGCCACAAAGTTATTGGCGGTGGTCCATA
AAGTGATTGAGGAGCATATCACGGTCAATCCATCATCACCGGCATTCCGTCATGGCAAGTCGTTAGGCTCTGGGAAAAAT
AAAGACTGGTCACGGGTAAAATTTGGTGCTGGTCGCTATCGTCTCTTCTTTCGTTACAGTGAAAAAGAGAAAGTCATCAT
TCTGGGATGGATGAACGATGAAAACACGCTGCGCACCTACGGTAAAAAAACAGATGCATATACCGTATTCAGTAAAATGT
TAAAAAGAGGACATCCTCCTGCCGACTGGGAAAGCCTCACCCAAGAGACAGAAGAAAACCATTGA

Antitoxin


Download         Length: 112 a.a.        Molecular weight: 12343.97 Da        Isoelectric Point: 4.8616

>AT73914 WP_001308975.1 NZ_CP020058:c3593239-3592904 [Escherichia coli]
MPANARSHAVLTTESKVTIRGQTTIPAPVREALKLKPGLDSIHYEILPGGQVFMCRLGDEQEDHTMNAFLRFLDADIQNN
PQKTRPFNIQQGKKLVAGMDVNIDDEIGDDE

Download         Length: 336 bp

>AT73914 NZ_CP020058:c3593239-3592904 [Escherichia coli]
ATGCCCGCTAATGCTCGCTCTCACGCTGTACTGACCACTGAATCAAAGGTCACGATACGCGGACAAACAACTATCCCCGC
GCCAGTGCGTGAGGCCTTAAAACTGAAGCCAGGCCTGGACAGCATTCATTACGAAATTCTGCCTGGTGGGCAAGTATTTA
TGTGCCGACTGGGAGATGAACAGGAGGATCATACTATGAATGCATTTTTGCGTTTTCTGGATGCAGATATCCAGAACAAC
CCGCAAAAAACTCGTCCATTCAACATTCAACAAGGAAAGAAACTTGTCGCTGGCATGGACGTCAACATTGATGATGAGAT
TGGCGACGACGAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829CJ20

Antitoxin

Source ID Structure
AlphaFold DB D6JF08

References