Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) hok-sok/-
Location 2211389..2211647 Replicon chromosome
Accession NZ_CP020058
Organism Escherichia coli strain AR_0061

Toxin (Protein)


Gene name hokC Uniprot ID S1NX00
Locus tag AM440_RS11385 Protein ID WP_000809168.1
Coordinates 2211495..2211647 (+) Length 51 a.a.

Antitoxin (RNA)


Gene name sokC
Locus tag -
Coordinates 2211389..2211446 (-)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AM440_RS11365 2206623..2207768 + 1146 Protein_2089 fimbria/pilus outer membrane usher protein -
AM440_RS11370 2207781..2208740 + 960 WP_000871686.1 hypothetical protein -
AM440_RS11375 2208778..2209677 - 900 WP_001300855.1 transcriptional activator NhaR -
AM440_RS11380 2209743..2210909 - 1167 WP_000681360.1 Na+/H+ antiporter NhaA -
- 2211389..2211446 - 58 - - Antitoxin
AM440_RS11385 2211495..2211647 + 153 WP_000809168.1 type I toxin-antitoxin system toxin MokC Toxin
AM440_RS11390 2211725..2212842 + 1118 Protein_2094 IS4-like element IS421 family transposase -
AM440_RS11395 2213105..2214235 - 1131 WP_001118464.1 molecular chaperone DnaJ -
AM440_RS11400 2214324..2216240 - 1917 WP_000516135.1 molecular chaperone DnaK -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Hok/gef cell toxic protein

(6-47)


Sequences

Toxin        


Download         Length: 51 a.a.        Molecular weight: 5501.57 Da        Isoelectric Point: 7.1312

>T73909 WP_000809168.1 NZ_CP020058:2211495-2211647 [Escherichia coli]
MKQHKAMIVALIVICITAVVAALVTRKDLCEVHIRTGQTEVAVFTAYESE

Download         Length: 153 bp

>T73909 NZ_CP020058:2211495-2211647 [Escherichia coli]
ATGAAGCAGCATAAGGCGATGATTGTCGCCCTGATCGTCATCTGTATCACCGCCGTAGTGGCGGCGCTGGTAACGAGAAA
AGACCTCTGTGAGGTTCACATCCGAACTGGCCAGACGGAGGTTGCTGTTTTCACGGCTTACGAATCCGAGTAA

Antitoxin


Download         Length: 58 bp

>AT73909 NZ_CP020058:c2211446-2211389 [Escherichia coli]
GTTCAGCATATAGGGGGCCTCGGGTTGATGGTAAAATATCACTCGGGGCTTTTCTCTA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1NX00

Antitoxin

Download structure file

References