Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-YefM
Location 248373..248875 Replicon chromosome
Accession NZ_CP020055
Organism Escherichia coli strain AR_0069

Toxin (Protein)


Gene name yoeB Uniprot ID -
Locus tag AM448_RS01470 Protein ID WP_000767835.1
Coordinates 248373..248627 (-) Length 85 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID S1Q063
Locus tag AM448_RS01475 Protein ID WP_001259255.1
Coordinates 248624..248875 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AM448_RS01445 243388..243615 - 228 WP_000985273.1 sulfurtransferase TusA family protein -
AM448_RS01450 243629..244687 - 1059 WP_000492320.1 transport protein YeeE -
AM448_RS01455 244866..246224 - 1359 WP_000019197.1 putrescine/proton symporter PlaP -
AM448_RS25015 246214..246276 - 63 WP_010723108.1 membrane protein YoeI -
AM448_RS01460 246491..247420 - 930 WP_000803351.1 LysR family transcriptional regulator -
AM448_RS01465 247466..248290 - 825 WP_000754737.1 SDR family oxidoreductase -
AM448_RS01470 248373..248627 - 255 WP_000767835.1 type II toxin-antitoxin system mRNA interferase toxin YoeB Toxin
AM448_RS01475 248624..248875 - 252 WP_001259255.1 YoeB-YefM toxin-antitoxin system antitoxin YefM Antitoxin
AM448_RS01480 249159..249209 + 51 WP_001364200.1 his operon leader peptide -
AM448_RS01490 249355..250254 + 900 WP_000131774.1 ATP phosphoribosyltransferase -
AM448_RS01495 250260..251564 + 1305 WP_001356284.1 histidinol dehydrogenase -
AM448_RS01500 251561..252631 + 1071 WP_000108941.1 histidinol-phosphate transaminase -
AM448_RS01505 252631..253698 + 1068 WP_000080072.1 bifunctional histidinol-phosphatase/imidazoleglycerol-phosphate dehydratase HisB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(2-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-73)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 10169.51 Da        Isoelectric Point: 7.2751

>T73884 WP_000767835.1 NZ_CP020055:c248627-248373 [Escherichia coli]
VKLIWSEESWDDYLYWQETDNRIVKKINELIKDTRRTPFEGKGKPEPLKHNLSGFWSRRITEEHRLVYAVTDDSLLIAAC
RYHY

Download         Length: 255 bp

>T73884 NZ_CP020055:c248627-248373 [Escherichia coli]
GTGAAACTAATCTGGTCTGAGGAGTCATGGGATGATTATCTGTACTGGCAGGAAACAGATAATCGAATTGTTAAAAAGAT
CAATGAACTTATCAAAGATACCCGCAGAACACCATTTGAAGGTAAGGGGAAGCCAGAACCCCTGAAGCATAATTTGTCAG
GCTTCTGGTCCCGACGCATTACAGAGGAGCACCGTCTGGTATACGCGGTTACTGACGATTCACTGCTCATTGCAGCATGT
CGTTATCATTATTGA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9307.58 Da        Isoelectric Point: 4.7954

>AT73884 WP_001259255.1 NZ_CP020055:c248875-248624 [Escherichia coli]
MRTISYSEARQNLSATMMKAVEDHAPILITRQNGEACVLMSLEEYNSLEETAYLLRSPANARRLMDSIDSLKSGKGTEKD
IIE

Download         Length: 252 bp

>AT73884 NZ_CP020055:c248875-248624 [Escherichia coli]
ATGCGTACAATTAGTTACAGCGAAGCGCGTCAGAATTTGTCGGCAACAATGATGAAAGCCGTTGAAGATCATGCCCCGAT
CCTTATTACTCGTCAGAATGGAGAGGCTTGTGTTCTGATGTCACTCGAAGAATACAACTCGCTGGAAGAGACGGCTTATC
TACTGCGTTCCCCCGCTAACGCCCGGAGATTGATGGACTCAATCGATAGCCTGAAATCAGGCAAAGGAACGGAAAAGGAC
ATTATTGAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
PDB 2A6Q
AlphaFold DB A0A7U9LNR0

References