Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 179218..179807 Replicon chromosome
Accession NZ_CP020046
Organism Thiomonas intermedia strain ATCC 15466

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag BVH73_RS00825 Protein ID WP_079415250.1
Coordinates 179218..179496 (+) Length 93 a.a.

Antitoxin (Protein)


Gene name graA Uniprot ID -
Locus tag BVH73_RS00830 Protein ID WP_079415252.1
Coordinates 179514..179807 (+) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BVH73_RS00810 175316..176314 - 999 WP_154048378.1 AraC family transcriptional regulator -
BVH73_RS00815 176347..177171 - 825 WP_079415246.1 SDR family oxidoreductase -
BVH73_RS00820 177785..179161 + 1377 WP_079415248.1 integrase family protein -
BVH73_RS00825 179218..179496 + 279 WP_079415250.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
BVH73_RS00830 179514..179807 + 294 WP_079415252.1 HigA family addiction module antidote protein Antitoxin
BVH73_RS15615 179888..180241 + 354 WP_154048379.1 hypothetical protein -
BVH73_RS00840 180234..180509 + 276 WP_079415256.1 hypothetical protein -
BVH73_RS00845 180617..181450 + 834 WP_079415258.1 hypothetical protein -
BVH73_RS00850 181544..181760 + 217 Protein_162 DNA-binding protein -
BVH73_RS00855 181760..182095 + 336 WP_079415260.1 helix-turn-helix domain-containing protein -
BVH73_RS00860 182312..183067 + 756 WP_079415262.1 hypothetical protein -
BVH73_RS00865 183067..183327 + 261 WP_079415264.1 hypothetical protein -
BVH73_RS00870 183324..184328 + 1005 WP_079415266.1 AAA family ATPase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 171492..188229 16737


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(1-92)

Antitoxin

Cro/C1-type helix-turn-helix domain

(11-65)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10523.93 Da        Isoelectric Point: 10.3048

>T73828 WP_079415250.1 NZ_CP020046:179218-179496 [Thiomonas intermedia]
MIRTFRHAGLEAFFHTGSKAGIQPHHATKLRLLLSALDNAKSPQDMNAPAWRLHPLTGNLAGHWAVWVNGNWRMTFRFTG
NDAELVDYRDYH

Download         Length: 279 bp

>T73828 NZ_CP020046:179218-179496 [Thiomonas intermedia]
ATGATTCGAACGTTTCGCCATGCTGGGCTTGAAGCCTTTTTCCACACGGGAAGCAAGGCAGGCATTCAGCCGCACCACGC
GACGAAGCTGCGCCTGCTGCTATCGGCCCTGGACAACGCCAAAAGCCCGCAAGACATGAACGCGCCAGCATGGCGATTGC
ACCCGCTAACCGGCAACCTTGCCGGGCATTGGGCCGTGTGGGTGAATGGCAACTGGCGCATGACGTTTCGATTCACGGGC
AACGATGCGGAGCTTGTGGACTACCGCGACTATCACTAG

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10763.56 Da        Isoelectric Point: 10.1916

>AT73828 WP_079415252.1 NZ_CP020046:179514-179807 [Thiomonas intermedia]
MSMMHNPAHPGEVLREWLPEGVTVTQAAEELHVARVTLSKLLNCRAGVSADMALRLADWLGTSPDLWQGMQGAWDLSQAR
KVKRPHIKPLPRMKTAA

Download         Length: 294 bp

>AT73828 NZ_CP020046:179514-179807 [Thiomonas intermedia]
ATGAGCATGATGCACAACCCAGCGCACCCCGGCGAGGTGCTGCGCGAATGGCTACCCGAAGGGGTGACGGTGACGCAGGC
CGCAGAAGAACTACACGTTGCCCGCGTGACGCTTTCCAAGTTGCTGAATTGCCGCGCTGGCGTGTCTGCCGATATGGCGC
TGCGCCTTGCCGATTGGCTAGGCACGTCCCCGGACTTGTGGCAGGGCATGCAGGGCGCCTGGGACTTGTCGCAGGCCCGC
AAGGTCAAGCGCCCGCACATCAAGCCATTGCCGCGAATGAAAACCGCCGCCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References