Detailed information of TA system TA073787

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): yefM-yoeB (relBE)/Txe-RelB
• Location: 2490033..2490532
• Replicon: chromosome
• Accession: NZ_CP020020
• Organism: Staphylococcus aureus strain ATCC 6538

Toxin (Protein)

• Gene name: yoeB
• Uniprot ID: -
• Locus tag: B4602_RS12985
• Protein ID: WP_000074044.1
• Coordinates: 2490033..2490275 (-)
• Length: 81 a.a.

Antitoxin (Protein)

• Gene name: yefM
• Uniprot ID: T1YBB2
• Locus tag: B4602_RS12990
• Protein ID: WP_000587618.1
• Coordinates: 2490275..2490532 (-)
• Length: 86 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
B4602_RS12965	2485338..2486525	-	1188	WP_000026189.1	MFS transporter	-
B4602_RS12970	2486921..2487697	-	777	WP_000072147.1	iron export ABC transporter permease subunit FetB	-
B4602_RS12975	2487690..2488352	-	663	WP_000923523.1	ATP-binding cassette domain-containing protein	-
B4602_RS12980	2488600..2489676	-	1077	WP_042727737.1	M42 family metallopeptidase	-
B4602_RS12985	2490033..2490275	-	243	WP_000074044.1	Txe/YoeB family addiction module toxin	Toxin
B4602_RS12990	2490275..2490532	-	258	WP_000587618.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
B4602_RS13000	2490891..2491346	+	456	WP_000732082.1	DUF1307 domain-containing protein	-
B4602_RS13005	2491514..2493091	-	1578	WP_000143494.1	FMN-binding glutamate synthase family protein	-
B4602_RS13010	2493286..2494035	+	750	WP_000072459.1	hypothetical protein	-
B4602_RS13015	2494266..2495459	-	1194	WP_000675411.1	MFS transporter	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin YoeB (6-79)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-68)

Sequences

Toxin

Protein

• Length: 81 a.a.
• Molecular weight: 9649.18 Da
• Isoelectric Point: 10.1469

>T73787 WP_000074044.1 NZ_CP020020:c2490275-2490033 [Staphylococcus aureus]
MSNYTVKIKNSAKLDLKKTFIEIVETLKNNPYKITQSFEKLEPKYLERYSRRINLQHRVVYTIDDRNKVVLILSAWSHYD

Nucleotide

• Length: 243 bp

>T73787 NZ_CP020020:c2490275-2490033 [Staphylococcus aureus]
ATGAGCAATTACACGGTTAAGATTAAAAATTCGGCGAAGTTAGATTTAAAGAAGACATTTATAGAAATTGTTGAGACTTT
AAAAAATAATCCTTATAAAATAACACAATCCTTTGAAAAATTAGAACCTAAATATTTAGAGCGATATTCAAGAAGAATTA
ACCTTCAGCACAGGGTCGTCTATACCATAGATGATCGAAATAAAGTAGTATTAATACTATCGGCATGGTCACATTATGAT
TAA

Antitoxin

Protein

• Length: 86 a.a.
• Molecular weight: 9762.78 Da
• Isoelectric Point: 4.1958

>AT73787 WP_000587618.1 NZ_CP020020:c2490532-2490275 [Staphylococcus aureus]
MIITSPTEARKDFYQLLKNVNNNHEPIYISGNNAENNAVIIGLEDWKSIQETMYLVSTGTMDKVREREKDNSGTTNIDDI
DWDNL

Nucleotide

• Length: 258 bp

>AT73787 NZ_CP020020:c2490532-2490275 [Staphylococcus aureus]
ATGATTATCACTAGCCCTACAGAAGCGAGAAAAGATTTTTATCAATTACTAAAAAATGTTAATAATAATCACGAACCAAT
TTATATTAGTGGTAATAATGCCGAAAATAATGCTGTGATTATAGGTTTAGAAGATTGGAAAAGTATACAAGAGACAATGT
ATCTTGTATCTACTGGTACAATGGACAAAGTAAGAGAAAGAGAAAAAGATAATAGTGGTACAACAAATATAGATGATATT
GATTGGGATAATCTTTAA

Structures

Antitoxin

• AlphaFold DB: T1YBB2