Detailed information of TA system TA073779

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-SprF1/-
• Location: 2000467..2000774
• Replicon: chromosome
• Accession: NZ_CP020020
• Organism: Staphylococcus aureus strain ATCC 6538

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: -
• Locus tag: B4602_RS10260
• Protein ID: WP_072353918.1
• Coordinates: 2000598..2000774 (-)
• Length: 59 a.a.

Antitoxin (RNA)

Gene name	SprF1
Locus tag	-
Coordinates	2000467..2000606 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
B4602_RS10200	1996033..1996212	+	180	WP_000669789.1	hypothetical protein	-
B4602_RS10210	1996523..1996783	+	261	WP_001791826.1	hypothetical protein	-
B4602_RS10215	1996836..1997186	-	351	WP_000702262.1	complement inhibitor SCIN-A	-
B4602_RS14615	1997696..1998031	-	336	Protein_1876	SH3 domain-containing protein	-
B4602_RS10240	1998683..1999174	-	492	WP_000920041.1	staphylokinase	-
B4602_RS10245	1999365..2000120	-	756	WP_000861038.1	CHAP domain-containing protein	-
B4602_RS10250	2000132..2000386	-	255	WP_000611512.1	phage holin	-
B4602_RS10255	2000438..2000545	+	108	WP_001791821.1	hypothetical protein	-
-	2000467..2000606	+	140	NuclAT_0	-	Antitoxin
-	2000467..2000606	+	140	NuclAT_0	-	Antitoxin
-	2000467..2000606	+	140	NuclAT_0	-	Antitoxin
-	2000467..2000606	+	140	NuclAT_0	-	Antitoxin
B4602_RS10260	2000598..2000774	-	177	WP_072353918.1	putative holin-like toxin	Toxin
B4602_RS10265	2000917..2001291	-	375	WP_000340977.1	hypothetical protein	-
B4602_RS10270	2001347..2001634	-	288	WP_001262620.1	hypothetical protein	-
B4602_RS10275	2001680..2001832	-	153	WP_001000058.1	hypothetical protein	-
B4602_RS10280	2001825..2005607	-	3783	WP_042727565.1	phage minor structural protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	scn / sak / hlb / groEL	1996836..2054467	57631

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (30-58)

Sequences

Toxin

Protein

• Length: 59 a.a.
• Molecular weight: 6810.43 Da
• Isoelectric Point: 9.9479

>T73779 WP_072353918.1 NZ_CP020020:c2000774-2000598 [Staphylococcus aureus]
MDRWWLSEYKEVVPMLALLKSLERRCLMITISTMLQFGLFLIALIGLVIKLIELSNKK

Nucleotide

• Length: 177 bp

>T73779 NZ_CP020020:c2000774-2000598 [Staphylococcus aureus]
TTGGATAGATGGTGGCTATCTGAGTATAAGGAGGTGGTGCCTATGTTGGCATTACTGAAATCTTTAGAAAGGAGATGCCT
AATGATTACAATTAGTACCATGTTGCAGTTTGGTTTATTCCTTATTGCATTGATAGGTCTAGTAATCAAGCTTATTGAAT
TAAGCAATAAAAAATAA

Antitoxin

Nucleotide

• Length: 140 bp

>AT73779 NZ_CP020020:2000467-2000606 [Staphylococcus aureus]
ATATATAGAAAAAGGGCAACATGCGCAAACATGTTACCCTAATGAGCCCGTTAAAAAGACGGTGGCTATTTTAGATTAAA
GATTAAATTAATAACCATTTAACCATCGAAACCAGCCAAAGTTAGCGATGGTTATTTTTT

Structures

Antitoxin