Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) SprA2-SprA2AS/-
Location 2493172..2493356 Replicon chromosome
Accession NZ_CP020019
Organism Staphylococcus aureus strain 08S00974

Toxin (Protein)


Gene name SprA2 Uniprot ID A0A2P7CQJ7
Locus tag B4603_RS12905 Protein ID WP_000482647.1
Coordinates 2493249..2493356 (-) Length 36 a.a.

Antitoxin (RNA)


Gene name SprA2AS
Locus tag -
Coordinates 2493172..2493232 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
B4603_RS12880 2488626..2488793 - 168 WP_001798790.1 hypothetical protein -
B4603_RS12890 2489024..2490757 - 1734 WP_000486511.1 ABC transporter ATP-binding protein/permease -
B4603_RS12895 2490782..2492545 - 1764 WP_001064818.1 ABC transporter ATP-binding protein/permease -
- 2493172..2493232 + 61 - - Antitoxin
B4603_RS12905 2493249..2493356 - 108 WP_000482647.1 type I toxin-antitoxin system Fst family toxin Toxin
B4603_RS12910 2493490..2493876 - 387 WP_000779355.1 flippase GtxA -
B4603_RS12915 2494143..2495285 + 1143 WP_001176859.1 glycerate kinase -
B4603_RS12920 2495345..2496004 + 660 WP_000831300.1 hypothetical protein -
B4603_RS12925 2496192..2497403 + 1212 WP_001191974.1 multidrug effflux MFS transporter -
B4603_RS12930 2497526..2497999 - 474 WP_000456489.1 GyrI-like domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.



Sequences

Toxin        


Download         Length: 36 a.a.        Molecular weight: 4012.76 Da        Isoelectric Point: 10.4935

>T73774 WP_000482647.1 NZ_CP020019:c2493356-2493249 [Staphylococcus aureus]
MFNLLIDIMTSALSGCLVAFFAHWLRTRNNKKGDK

Download         Length: 108 bp

>T73774 NZ_CP020019:c2493356-2493249 [Staphylococcus aureus]
ATGTTCAATTTATTAATTGACATCATGACTTCAGCTTTAAGCGGCTGTCTTGTTGCGTTTTTTGCACATTGGTTACGAAC
GCGCAACAATAAAAAAGGTGACAAATAA

Antitoxin


Download         Length: 61 bp

>AT73774 NZ_CP020019:2493172-2493232 [Staphylococcus aureus]
TACATAATAAATTGAACATCTAAATACACCAAATCCCCTCACTACTGCCATAGTGAGGGGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2P7CQJ7

Antitoxin

Download structure file

References