Detailed information of TA system TA073766

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): TMCS/-
• Location: 1588240..1588819
• Replicon: chromosome
• Accession: NZ_CP020019
• Organism: Staphylococcus aureus strain 08S00974

Toxin (Protein)

• Gene name: MW1434
• Uniprot ID: A0A4P7P609
• Locus tag: B4603_RS07945
• Protein ID: WP_001025401.1
• Coordinates: 1588574..1588819 (-)
• Length: 82 a.a.

Antitoxin (RNA)

Gene name	MW1433
Locus tag	-
Coordinates	1588240..1588605 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
B4603_RS07905	1584981..1585538	-	558	WP_000645042.1	DUF2815 family protein	-
B4603_RS07910	1585564..1586730	-	1167	WP_079219804.1	DUF2800 domain-containing protein	-
B4603_RS07915	1586727..1587089	-	363	WP_031863778.1	hypothetical protein	-
B4603_RS07920	1587104..1587427	-	324	WP_000174994.1	hypothetical protein	-
B4603_RS07925	1587506..1587667	-	162	WP_001285948.1	DUF1270 domain-containing protein	-
B4603_RS07930	1587680..1587943	-	264	WP_001596347.1	helix-turn-helix domain-containing protein	-
B4603_RS07935	1587970..1588185	-	216	WP_001097552.1	hypothetical protein	-
B4603_RS07940	1588240..1588605	+	366	WP_001128433.1	hypothetical protein	Antitoxin
B4603_RS07945	1588574..1588819	-	246	WP_001025401.1	DUF2829 domain-containing protein	Toxin
B4603_RS07950	1588886..1589266	+	381	WP_000773059.1	DUF2513 domain-containing protein	-
B4603_RS07955	1589253..1589450	-	198	WP_001148860.1	hypothetical protein	-
B4603_RS07960	1589520..1589732	+	213	WP_000362644.1	hypothetical protein	-
B4603_RS14540	1589773..1589922	-	150	WP_000771849.1	hypothetical protein	-
B4603_RS07965	1589951..1590727	-	777	WP_031886646.1	Rha family transcriptional regulator	-
B4603_RS07970	1590766..1590975	-	210	WP_001114715.1	helix-turn-helix transcriptional regulator	-
B4603_RS07975	1591138..1591464	+	327	WP_000455972.1	helix-turn-helix domain-containing protein	-
B4603_RS07980	1591486..1591944	+	459	WP_000521395.1	hypothetical protein	-
B4603_RS07985	1591962..1592546	+	585	WP_079219805.1	hypothetical protein	-
B4603_RS07990	1592776..1592922	+	147	WP_001795334.1	hypothetical protein	-
B4603_RS07995	1592919..1593533	-	615	WP_000191464.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	1543851..1612495	68644

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Protein of unknown function DUF2829 (2-69)

Sequences

Toxin

Protein

• Length: 82 a.a.
• Molecular weight: 9468.72 Da
• Isoelectric Point: 5.7783

>T73766 WP_001025401.1 NZ_CP020019:c1588819-1588574 [Staphylococcus aureus]
MNIQEATKIATKNLVSMTRKDWKESHRTKILPTNDSFLQCIISNSDGTNLIRYWQPSADDLMANDWEVINPTRDQELLKQ
F

Nucleotide

• Length: 246 bp

>T73766 NZ_CP020019:c1588819-1588574 [Staphylococcus aureus]
ATGAACATTCAAGAAGCAACTAAGATAGCTACAAAAAATCTTGTCTCTATGACACGGAAAGATTGGAAAGAAAGTCATCG
AACTAAGATATTACCAACAAATGATAGTTTTTTACAATGCATCATTTCAAATAGCGATGGGACAAACCTTATCAGATATT
GGCAACCTTCAGCCGATGACCTCATGGCAAATGATTGGGAAGTTATAAACCCAACTAGAGACCAGGAATTATTGAAGCAA
TTTTAG

Antitoxin

Nucleotide

• Length: 366 bp

>AT73766 NZ_CP020019:1588240-1588605 [Staphylococcus aureus]
ATGCCCTTGATATCTGATGAATTTGATACACTTACTAAAGACCAACAATATATCTTGTCCGTACTCTACAAAGATTATTT
AGAATGTGTAAAGTTAGGTTCGGTTAAATTAACCTGCAATAATTTTGGAAGTGCTAAAGATATACATACAAAGTATTTTC
AAAAACTACATTTCGAAGATGTAAAATACGATTTAAATAAACTTAAAAACTCTGGGTTCCTAAACGGCGTGTATGCTAGT
AACACTATTTATCATGTAACAATTTCAGACAAGACTGTTGTTTACTTTGAAAATGAGTTTAAAAACAATTTAAAAAGTAT
CATTGATAGCATTTCTAAAATTGCTTCAATAATTCCTGGTCTCTAG

Structures

Toxin

• AlphaFold DB: A0A4P7P609

Antitoxin