Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) DinJ-YafQ (relBE)/YafQ-DinJ
Location 1640091..1640610 Replicon chromosome
Accession NZ_CP020017
Organism Tetragenococcus halophilus strain KUD23

Toxin (Protein)


Gene name yafQ Uniprot ID A0A2H6D1U4
Locus tag B2J85_RS07865 Protein ID WP_014123908.1
Coordinates 1640091..1640375 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name dinJ Uniprot ID A0A2H6CTG1
Locus tag B2J85_RS07870 Protein ID WP_014123907.1
Coordinates 1640365..1640610 (-) Length 82 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
B2J85_RS07850 1635622..1636461 - 840 WP_014123911.1 PRD domain-containing protein -
B2J85_RS07855 1636483..1637955 - 1473 WP_014123910.1 glycoside hydrolase family 1 protein -
B2J85_RS07860 1637977..1639842 - 1866 WP_014123909.1 beta-glucoside-specific PTS transporter subunit IIABC -
B2J85_RS07865 1640091..1640375 - 285 WP_014123908.1 type II toxin-antitoxin system YafQ family toxin Toxin
B2J85_RS07870 1640365..1640610 - 246 WP_014123907.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
B2J85_RS07875 1640831..1641538 + 708 WP_014123906.1 DUF969 domain-containing protein -
B2J85_RS07880 1641522..1642442 + 921 WP_014123905.1 DUF979 domain-containing protein -
B2J85_RS07885 1642769..1643416 + 648 WP_014123904.1 pyroglutamyl-peptidase I -
B2J85_RS07890 1643572..1643754 + 183 WP_014123901.1 putative holin-like toxin -
B2J85_RS07895 1643967..1644233 - 267 WP_014123900.1 type II toxin-antitoxin system RelE/ParE family toxin -
B2J85_RS07900 1644230..1644460 - 231 WP_014123899.1 hypothetical protein -
B2J85_RS07905 1644627..1644863 + 237 WP_014123898.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(11-93)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-65)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11711.52 Da        Isoelectric Point: 10.0281

>T73760 WP_014123908.1 NZ_CP020017:c1640375-1640091 [Tetragenococcus halophilus]
MKNNPKYKPAFERKFKKHYKNMLKGGRYKKEDFEKVYWKLLYDEQLEPRYNDHPLVNRKPERDLHIKPDWLLIYKYDGEF
VRFIDTGTHADLFK

Download         Length: 285 bp

>T73760 NZ_CP020017:c1640375-1640091 [Tetragenococcus halophilus]
ATGAAGAATAATCCTAAATATAAGCCAGCTTTTGAGAGAAAATTTAAGAAGCATTATAAAAATATGCTTAAGGGTGGTCG
TTATAAAAAAGAGGACTTTGAAAAAGTTTATTGGAAACTTTTATATGATGAACAACTGGAACCAAGATACAACGATCATC
CTTTGGTAAATCGAAAACCTGAACGTGATTTGCATATCAAGCCAGATTGGTTGTTGATTTATAAATACGATGGTGAGTTT
GTCCGGTTTATCGATACGGGCACTCATGCCGATCTCTTTAAATAA

Antitoxin


Download         Length: 82 a.a.        Molecular weight: 9519.59 Da        Isoelectric Point: 4.1475

>AT73760 WP_014123907.1 NZ_CP020017:c1640610-1640365 [Tetragenococcus halophilus]
MTNQVHFRIDEEDKEKFRIVMQRVGLEPNEAYRIFVKRAIEVGGIPFEVSDPSSQLEEAIKSQDYIEFEDGKEGLDWLNE
E

Download         Length: 246 bp

>AT73760 NZ_CP020017:c1640610-1640365 [Tetragenococcus halophilus]
ATGACGAATCAAGTACACTTTAGGATAGATGAAGAGGATAAAGAAAAGTTTAGAATTGTGATGCAACGTGTAGGTTTAGA
GCCTAACGAAGCTTATCGGATCTTTGTTAAAAGGGCAATCGAAGTTGGAGGAATCCCGTTCGAAGTTTCGGATCCATCTT
CTCAATTAGAGGAGGCCATTAAAAGCCAGGACTATATTGAATTTGAAGACGGTAAGGAAGGCTTGGATTGGTTAAATGAA
GAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2H6D1U4

Antitoxin

Source ID Structure
AlphaFold DB A0A2H6CTG1

References