Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) HipBST/HipA-HipA
Location 721875..723223 Replicon chromosome
Accession NZ_CP020014
Organism Haemophilus influenzae strain 11P6H

Toxin (Protein)


Gene name HipT Uniprot ID A0A5C6GXP8
Locus tag BVZ63_RS03570 Protein ID WP_012054635.1
Coordinates 721875..722906 (-) Length 344 a.a.

Antitoxin (Protein)


Gene name HipS Uniprot ID A0A2R3FM14
Locus tag BVZ63_RS03575 Protein ID WP_005687922.1
Coordinates 722903..723223 (-) Length 107 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BVZ63_RS03555 718178..718342 + 165 WP_012054638.1 hypothetical protein -
BVZ63_RS03560 718395..720140 + 1746 WP_012054637.1 ABC transporter ATP-binding protein/permease -
BVZ63_RS03565 720133..721791 + 1659 WP_012054636.1 thiol reductant ABC exporter subunit CydC -
BVZ63_RS03570 721875..722906 - 1032 WP_012054635.1 type II toxin-antitoxin system HipA family toxin Toxin
BVZ63_RS03575 722903..723223 - 321 WP_005687922.1 type II toxin-antitoxin system HipA family toxin Antitoxin
BVZ63_RS03580 723211..723519 - 309 WP_005661200.1 helix-turn-helix domain-containing protein -
BVZ63_RS03585 723719..724720 - 1002 WP_005687920.1 class II fructose-bisphosphatase -
BVZ63_RS03590 724882..725100 + 219 WP_005650820.1 cell division protein ZapB -
BVZ63_RS03595 725194..725634 + 441 WP_005687918.1 FMN-binding protein MioC -
BVZ63_RS03600 725631..726065 + 435 WP_005687917.1 D-tyrosyl-tRNA(Tyr) deacylase -
BVZ63_RS03605 726367..726843 - 477 WP_005687916.1 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase -
BVZ63_RS03610 726840..727517 - 678 WP_005655267.1 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase -
BVZ63_RS03615 727517..727795 - 279 WP_005665661.1 cell division protein FtsB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(56-290)

Antitoxin

HipA, N-terminal subdomain 1

(9-101)


Sequences

Toxin        


Download         Length: 344 a.a.        Molecular weight: 39830.34 Da        Isoelectric Point: 6.5052

>T73753 WP_012054635.1 NZ_CP020014:c722906-721875 [Haemophilus influenzae]
MNFCRILLKPLKKNEVHSDYSTKGLHYLTGNKHFNPELPFSRQEFITVKPQKQQGMSISGFQPKLQLIIKDGHFDSVNQQ
GNYILKPSPEEYPFLAENEHATMRIMKELGFDVPENGLVSFAGEQNHKEFAFVIKRFDRDEQQTEIHQEQLDGAMNIRDK
YGKIGADNEQYVSYEQIAKFILQHTENHLAQQREIFRRIIYAYLLGNNDLHLRNFSFIYPKNSHPKLAPIYDFVSVSPYP
EIFNSTLLALPLLAREEGNATLAKGFNTQYGEYIGDDFVEFGENIGLNKNVIIQKLIPEITQEKEKVEQIYSQSFMPQPH
IDCVLKTYRKRLALLNVLNEPEL

Download         Length: 1032 bp

>T73753 NZ_CP020014:c722906-721875 [Haemophilus influenzae]
ATGAATTTTTGTCGTATTTTATTAAAGCCATTAAAGAAAAATGAAGTTCATTCTGACTACAGCACAAAAGGTTTACATTA
CCTTACAGGCAATAAACATTTTAATCCTGAATTACCCTTTTCTCGCCAAGAATTTATTACAGTGAAACCCCAAAAACAGC
AAGGAATGAGCATTTCAGGTTTTCAACCAAAATTACAGCTTATTATCAAAGATGGGCACTTTGACAGCGTAAATCAACAG
GGAAATTATATTTTAAAGCCCTCTCCAGAAGAGTATCCTTTTTTAGCTGAAAATGAACACGCCACCATGCGCATTATGAA
AGAATTAGGGTTTGATGTGCCAGAAAATGGTTTAGTTTCTTTTGCTGGCGAACAAAATCATAAGGAATTTGCTTTTGTTA
TAAAGCGTTTTGATCGTGATGAACAACAAACAGAGATTCACCAAGAACAACTTGATGGTGCAATGAATATTCGAGACAAG
TACGGAAAAATAGGTGCAGATAATGAGCAATATGTGAGTTATGAACAAATTGCTAAGTTTATTTTGCAGCACACTGAAAA
TCATTTAGCTCAGCAACGAGAAATTTTTCGTCGAATTATTTACGCTTATTTATTAGGAAATAATGATCTTCACTTACGCA
ATTTTTCATTTATTTATCCCAAAAACAGTCATCCAAAACTTGCTCCAATTTATGACTTTGTGTCGGTGTCGCCCTATCCT
GAAATATTTAATTCAACACTACTTGCTTTGCCATTGTTAGCGCGAGAAGAAGGTAATGCCACACTAGCCAAAGGATTTAA
TACTCAATACGGTGAATATATCGGCGATGATTTTGTCGAGTTTGGGGAAAATATTGGATTAAATAAAAATGTGATTATTC
AAAAATTAATTCCTGAAATTACACAAGAAAAGGAAAAAGTAGAGCAGATTTATTCACAATCCTTTATGCCGCAGCCACAT
ATTGATTGCGTGCTGAAAACTTATCGCAAGCGTTTAGCATTACTTAACGTATTAAATGAACCTGAACTATAA

Antitoxin


Download         Length: 107 a.a.        Molecular weight: 12407.09 Da        Isoelectric Point: 5.9670

>AT73753 WP_005687922.1 NZ_CP020014:c723223-722903 [Haemophilus influenzae]
MRDLVRSGKVFLYGEFIGLLREDHRGFHFAYNPDYQGIPLSLSFPIEQSPFHSDTLFPYFASLVPEGWLKHKYALHQRID
EGDMFRFLLNNGENMLGAVQIQEEKQ

Download         Length: 321 bp

>AT73753 NZ_CP020014:c723223-722903 [Haemophilus influenzae]
ATGCGCGATTTAGTCCGCTCGGGAAAAGTATTTCTCTACGGCGAATTTATTGGCTTACTTAGAGAAGATCATCGTGGTTT
TCATTTTGCTTACAATCCCGATTATCAAGGAATACCGCTCTCTCTCAGCTTTCCTATTGAGCAAAGCCCTTTTCATTCTG
ACACCTTATTCCCTTATTTTGCATCGCTCGTCCCAGAAGGCTGGCTAAAACACAAATATGCACTTCATCAACGAATTGAT
GAAGGCGATATGTTTCGCTTTTTACTTAATAACGGGGAAAATATGTTAGGTGCAGTGCAAATTCAGGAGGAAAAACAATG
A

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A5C6GXP8

Antitoxin

Source ID Structure
AlphaFold DB A0A2R3FM14

References