Detailed information of TA system TA073744

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): HipBST/HipA-HipA
• Location: 809679..811027
• Replicon: chromosome
• Accession: NZ_CP020013
• Organism: Haemophilus influenzae strain 6P32H1

Toxin (Protein)

• Gene name: HipT
• Uniprot ID: -
• Locus tag: BV140_RS04115
• Protein ID: WP_005687924.1
• Coordinates: 809679..810710 (-)
• Length: 344 a.a.

Antitoxin (Protein)

• Gene name: HipS
• Uniprot ID: A0A2R3FM14
• Locus tag: BV140_RS04120
• Protein ID: WP_005687922.1
• Coordinates: 810707..811027 (-)
• Length: 107 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
BV140_RS04105	806199..807944	+	1746	WP_005687928.1	ABC transporter ATP-binding protein/permease	-
BV140_RS04110	807937..809595	+	1659	WP_005687926.1	thiol reductant ABC exporter subunit CydC	-
BV140_RS04115	809679..810710	-	1032	WP_005687924.1	type II toxin-antitoxin system HipA family toxin	Toxin
BV140_RS04120	810707..811027	-	321	WP_005687922.1	type II toxin-antitoxin system HipA family toxin	Antitoxin
BV140_RS04125	811015..811323	-	309	WP_005661200.1	helix-turn-helix domain-containing protein	-
BV140_RS04130	811523..812524	-	1002	WP_005687920.1	class II fructose-bisphosphatase	-
BV140_RS04135	812686..812904	+	219	WP_005650820.1	cell division protein ZapB	-
BV140_RS04140	812998..813438	+	441	WP_005687918.1	FMN-binding protein MioC	-
BV140_RS04145	813435..813869	+	435	WP_005687917.1	D-tyrosyl-tRNA(Tyr) deacylase	-
BV140_RS04150	814171..814647	-	477	WP_005687916.1	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase	-
BV140_RS04155	814644..815321	-	678	WP_005655267.1	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase	-
BV140_RS04160	815321..815599	-	279	WP_005665661.1	cell division protein FtsB	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HipA-like, C-terminal (56-290)

Antitoxin

• HipA, N-terminal subdomain 1 (9-101)

Sequences

Toxin

Protein

• Length: 344 a.a.
• Molecular weight: 39846.34 Da
• Isoelectric Point: 6.5052

>T73744 WP_005687924.1 NZ_CP020013:c810710-809679 [Haemophilus influenzae]
MNFCRILLKPLKKNEVHSDYSTKGLHYLTGNKHFNPELPFSRQEFITVKPQKQQGMSISGFQPKLQLIIKDGHFDSVNQQ
GNYILKPSPEEYPFLAENEHATMRIMKELGFDVPENGLVSFAGEQNHKEFAFVIKRFDRDEQQTEIHQEQLDGAMNIRDK
YGKIGADNEQYVSYEQIAKFILQHTENHLAQQREIFRRIIYAYLLGNNDLHLRNFSFIYPKNSHPKLAPIYDFVSVSPYP
EIFNSTLLALPLLAREEGNATLAKGFNTQYGEYIGDDFVEFGENIGLNKNVIIQKLIPEITQEKEKVEQVYSQSFMPQPH
IDCVLKTYRKRLTLLNVLNEPEL

Nucleotide

• Length: 1032 bp

>T73744 NZ_CP020013:c810710-809679 [Haemophilus influenzae]
ATGAATTTTTGTCGTATTTTATTAAAGCCATTAAAGAAAAATGAAGTTCATTCTGACTACAGCACAAAAGGTTTACATTA
CCTTACAGGCAATAAACATTTTAATCCTGAATTACCCTTTTCTCGCCAAGAATTTATTACAGTGAAACCCCAAAAACAGC
AAGGAATGAGCATTTCAGGTTTTCAACCAAAATTACAGCTTATTATCAAAGATGGGCACTTTGACAGCGTAAATCAACAG
GGAAATTATATTTTAAAGCCCTCTCCAGAAGAGTATCCTTTTTTAGCTGAAAATGAACACGCCACCATGCGCATTATGAA
AGAATTAGGGTTTGATGTGCCAGAAAATGGTTTAGTTTCTTTTGCTGGCGAACAAAATCATAAGGAATTTGCTTTTGTTA
TAAAGCGTTTTGATCGTGATGAACAACAAACAGAGATTCACCAAGAACAACTTGATGGTGCAATGAATATTCGAGACAAG
TACGGAAAAATAGGTGCAGATAATGAGCAATATGTGAGTTATGAACAAATTGCTAAGTTTATTTTGCAGCACACTGAAAA
TCATTTAGCTCAGCAACGAGAAATTTTTCGTCGAATTATTTACGCTTATTTATTAGGAAATAATGATCTTCACTTACGCA
ATTTTTCATTTATTTATCCCAAAAACAGTCATCCAAAACTTGCTCCAATTTATGACTTTGTGTCGGTGTCGCCCTATCCT
GAAATATTTAATTCAACACTACTTGCTTTGCCATTGTTAGCGCGAGAAGAAGGTAATGCCACACTAGCCAAAGGATTTAA
TACTCAATACGGTGAATATATCGGCGATGATTTTGTCGAGTTTGGGGAAAATATTGGATTAAATAAAAATGTGATTATTC
AAAAATTAATTCCTGAAATTACACAAGAAAAGGAAAAGGTGGAGCAGGTTTATTCACAATCCTTTATGCCGCAACCGCAT
ATTGATTGCGTACTGAAAACTTATCGCAAGCGTTTAACGTTACTTAACGTATTAAATGAACCTGAGCTATAA

Antitoxin

Protein

• Length: 107 a.a.
• Molecular weight: 12407.09 Da
• Isoelectric Point: 5.9670

>AT73744 WP_005687922.1 NZ_CP020013:c811027-810707 [Haemophilus influenzae]
MRDLVRSGKVFLYGEFIGLLREDHRGFHFAYNPDYQGIPLSLSFPIEQSPFHSDTLFPYFASLVPEGWLKHKYALHQRID
EGDMFRFLLNNGENMLGAVQIQEEKQ

Nucleotide

• Length: 321 bp

>AT73744 NZ_CP020013:c811027-810707 [Haemophilus influenzae]
ATGCGCGATTTAGTCCGCTCGGGAAAAGTATTTCTCTACGGCGAATTTATTGGCTTACTTAGAGAAGATCATCGTGGTTT
TCATTTTGCTTACAATCCCGATTATCAAGGAATACCGCTCTCTCTCAGCTTTCCTATTGAGCAAAGCCCTTTTCATTCTG
ACACCTTATTCCCTTATTTTGCATCGCTCGTCCCAGAAGGCTGGCTAAAACACAAATATGCACTTCATCAACGAATTGAT
GAAGGCGATATGTTTCGCTTTTTACTTAATAACGGGGAAAATATGTTAGGTGCAGTGCAAATTCAGGAGGAAAAACAATG
A

Structures

Antitoxin

• AlphaFold DB: A0A2R3FM14