73727

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) HipBST/HipA-HipA
Location 718001..719349 Replicon chromosome
Accession NZ_CP020011
Organism Haemophilus influenzae strain 67P56H1

Toxin (Protein)


Gene name HipT Uniprot ID -
Locus tag BV134_RS03610 Protein ID WP_050822754.1
Coordinates 718001..719032 (-) Length 344 a.a.

Antitoxin (Protein)


Gene name HipS Uniprot ID -
Locus tag BV134_RS03615 Protein ID WP_048954894.1
Coordinates 719029..719349 (-) Length 107 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BV134_RS03600 714522..716267 + 1746 WP_050822749.1 ABC transporter ATP-binding protein/permease -
BV134_RS03605 716260..717918 + 1659 WP_050822751.1 ABC transporter ATP-binding protein/permease -
BV134_RS03610 718001..719032 - 1032 WP_050822754.1 type II toxin-antitoxin system HipA family toxin Toxin
BV134_RS03615 719029..719349 - 321 WP_048954894.1 type II toxin-antitoxin system HipA family toxin Antitoxin
BV134_RS03620 719337..719645 - 309 WP_005661200.1 helix-turn-helix domain-containing protein -
BV134_RS03625 719845..720846 - 1002 WP_005690169.1 class II fructose-bisphosphatase -
BV134_RS03630 721008..721226 + 219 WP_005650820.1 cell division protein ZapB -
BV134_RS03635 721323..721763 + 441 WP_005667635.1 FMN-binding protein MioC -
BV134_RS03640 721760..722194 + 435 WP_005667636.1 D-tyrosyl-tRNA(Tyr) deacylase -
BV134_RS03645 722506..722982 - 477 WP_005687916.1 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase -
BV134_RS03650 722979..723656 - 678 WP_050822756.1 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase -
BV134_RS03655 723656..723934 - 279 WP_005665661.1 cell division protein FtsB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(56-290)

Antitoxin

HipA, N-terminal subdomain 1

(9-101)


Sequences

Toxin        


Download         Length: 344 a.a.        Molecular weight: 39795.39 Da        Isoelectric Point: 6.3487

>T73727 WP_050822754.1 NZ_CP020011:c719032-718001 [Haemophilus influenzae]
MNFCRILLKPLKKNEALSGYSAEGLHYLTGNKNFNPELPFSRQEFITVKPQKQQGMSISGFQPKLQLIIEDEHFDSVNQQ
GNYILKPSPEEYPFLAENEHATMRIMKELGFDVPENGLVSFAGEQNHKEFAFVIKRFDRDKQQKPMHQEQLDGAMNIRDK
YGKIGADNEQYVSYEQIAKFILQHTENHLAQQREIFRRIIYAYLLGNNDLHLRNFSFIYPKNSHPKLAPIYDFVSVSPYP
EIFNSTLLALPLLVREEGNATLAKGFNTQYGEYIGDDFVEFGENIGLNKNVIIQKLIPEITQEKEKVEQIYSQSFMPQPH
IDCVLKTYRKRLALLNLLNEPEL

Download         Length: 1032 bp

>T73727 NZ_CP020011:c719032-718001 [Haemophilus influenzae]
ATGAATTTTTGTCGTATTTTATTAAAGCCATTGAAGAAAAATGAAGCACTTTCAGGTTACAGTGCTGAAGGTTTGCATTA
CCTTACAGGCAATAAAAATTTTAATCCTGAATTACCCTTTTCTCGCCAAGAATTTATTACCGTGAAACCCCAAAAACAGC
AAGGAATGAGCATTTCAGGTTTTCAACCAAAATTACAGCTTATTATCGAAGATGAGCACTTTGACAGCGTAAATCAACAG
GGAAATTATATTTTAAAGCCCTCTCCAGAAGAGTATCCTTTTTTAGCTGAAAATGAACACGCCACCATGCGCATTATGAA
AGAATTAGGGTTTGATGTGCCAGAAAATGGTTTAGTTTCTTTTGCTGGCGAACAAAATCATAAAGAATTTGCTTTTGTTA
TAAAGCGTTTTGATCGTGATAAACAGCAAAAACCAATGCACCAAGAACAACTTGATGGTGCAATGAATATTCGAGACAAG
TATGGAAAAATAGGTGCAGATAATGAGCAATATGTGAGTTATGAACAAATTGCTAAGTTTATTTTACAACACACCGAAAA
TCATTTAGCTCAGCAACGAGAAATTTTTCGTCGAATTATTTACGCTTATTTATTAGGAAATAATGATCTTCACTTACGCA
ATTTTTCATTTATTTATCCCAAAAACAGTCATCCAAAACTTGCTCCAATTTATGATTTTGTGTCAGTGTCGCCCTATCCT
GAAATATTTAATTCAACACTACTTGCCTTGCCATTGTTAGTGCGAGAAGAGGGTAATGCCACACTAGCCAAAGGATTTAA
TACTCAATACGGTGAATATATCGGCGATGATTTTGTCGAGTTTGGGGAAAATATTGGATTAAATAAAAATGTGATTATTC
AAAAATTAATTCCTGAAATTACACAAGAAAAGGAAAAAGTAGAGCAGATTTATTCACAATCCTTTATGCCGCAGCCACAT
ATTGATTGCGTGCTGAAAACTTATCGCAAGCGTTTAGCTTTGCTTAACCTATTAAATGAACCTGAACTATAA

Antitoxin


Download         Length: 107 a.a.        Molecular weight: 12433.09 Da        Isoelectric Point: 6.2114

>AT73727 WP_048954894.1 NZ_CP020011:c719349-719029 [Haemophilus influenzae]
MRNLVRSGKVFLYGEFIGLLREDHHGFHFSYNPDYQGIPLSLSFPIEQSPFHSDTLFPYFASLVPEGWLKHKYALHQRID
ESDMFRFLLNNGENMLGAVQIQEEKQ

Download         Length: 321 bp

>AT73727 NZ_CP020011:c719349-719029 [Haemophilus influenzae]
ATGCGCAATTTAGTCCGCTCGGGAAAAGTATTTCTCTACGGCGAATTTATTGGCTTACTTAGAGAAGATCATCATGGTTT
TCATTTTTCTTACAACCCCGATTATCAAGGAATACCGCTCTCTCTCAGCTTTCCTATTGAGCAAAGTCCTTTTCATTCTG
ACACCTTATTCCCTTATTTTGCATCGCTCGTCCCAGAAGGCTGGCTAAAACACAAATATGCACTTCATCAACGAATTGAT
GAAAGCGATATGTTTCGCTTTTTACTTAATAACGGGGAAAATATGTTAGGTGCAGTGCAAATTCAGGAAGAAAAACAATG
A

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References