Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) HipBST/HipA-HipA
Location 718080..719428 Replicon chromosome
Accession NZ_CP020010
Organism Haemophilus influenzae strain 67P38H1

Toxin (Protein)


Gene name HipT Uniprot ID -
Locus tag BV131_RS03620 Protein ID WP_050822754.1
Coordinates 718080..719111 (-) Length 344 a.a.

Antitoxin (Protein)


Gene name HipS Uniprot ID -
Locus tag BV131_RS03625 Protein ID WP_048954894.1
Coordinates 719108..719428 (-) Length 107 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BV131_RS03610 714601..716346 + 1746 WP_050822749.1 ABC transporter ATP-binding protein/permease -
BV131_RS03615 716339..717997 + 1659 WP_050822751.1 ABC transporter ATP-binding protein/permease -
BV131_RS03620 718080..719111 - 1032 WP_050822754.1 type II toxin-antitoxin system HipA family toxin Toxin
BV131_RS03625 719108..719428 - 321 WP_048954894.1 type II toxin-antitoxin system HipA family toxin Antitoxin
BV131_RS03630 719416..719724 - 309 WP_005661200.1 helix-turn-helix domain-containing protein -
BV131_RS03635 719924..720925 - 1002 WP_005690169.1 class II fructose-bisphosphatase -
BV131_RS03640 721087..721305 + 219 WP_005650820.1 cell division protein ZapB -
BV131_RS03645 721402..721842 + 441 WP_005667635.1 FMN-binding protein MioC -
BV131_RS03650 721839..722273 + 435 WP_005667636.1 D-tyrosyl-tRNA(Tyr) deacylase -
BV131_RS03655 722585..723061 - 477 WP_005687916.1 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase -
BV131_RS03660 723058..723735 - 678 WP_050822756.1 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase -
BV131_RS03665 723735..724013 - 279 WP_005665661.1 cell division protein FtsB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(56-290)

Antitoxin

HipA, N-terminal subdomain 1

(9-101)


Sequences

Toxin        


Download         Length: 344 a.a.        Molecular weight: 39795.39 Da        Isoelectric Point: 6.3487

>T73719 WP_050822754.1 NZ_CP020010:c719111-718080 [Haemophilus influenzae]
MNFCRILLKPLKKNEALSGYSAEGLHYLTGNKNFNPELPFSRQEFITVKPQKQQGMSISGFQPKLQLIIEDEHFDSVNQQ
GNYILKPSPEEYPFLAENEHATMRIMKELGFDVPENGLVSFAGEQNHKEFAFVIKRFDRDKQQKPMHQEQLDGAMNIRDK
YGKIGADNEQYVSYEQIAKFILQHTENHLAQQREIFRRIIYAYLLGNNDLHLRNFSFIYPKNSHPKLAPIYDFVSVSPYP
EIFNSTLLALPLLVREEGNATLAKGFNTQYGEYIGDDFVEFGENIGLNKNVIIQKLIPEITQEKEKVEQIYSQSFMPQPH
IDCVLKTYRKRLALLNLLNEPEL

Download         Length: 1032 bp

>T73719 NZ_CP020010:c719111-718080 [Haemophilus influenzae]
ATGAATTTTTGTCGTATTTTATTAAAGCCATTGAAGAAAAATGAAGCACTTTCAGGTTACAGTGCTGAAGGTTTGCATTA
CCTTACAGGCAATAAAAATTTTAATCCTGAATTACCCTTTTCTCGCCAAGAATTTATTACCGTGAAACCCCAAAAACAGC
AAGGAATGAGCATTTCAGGTTTTCAACCAAAATTACAGCTTATTATCGAAGATGAGCACTTTGACAGCGTAAATCAACAG
GGAAATTATATTTTAAAGCCCTCTCCAGAAGAGTATCCTTTTTTAGCTGAAAATGAACACGCCACCATGCGCATTATGAA
AGAATTAGGGTTTGATGTGCCAGAAAATGGTTTAGTTTCTTTTGCTGGCGAACAAAATCATAAAGAATTTGCTTTTGTTA
TAAAGCGTTTTGATCGTGATAAACAGCAAAAACCAATGCACCAAGAACAACTTGATGGTGCAATGAATATTCGAGACAAG
TATGGAAAAATAGGTGCAGATAATGAGCAATATGTGAGTTATGAACAAATTGCTAAGTTTATTTTACAACACACCGAAAA
TCATTTAGCTCAGCAACGAGAAATTTTTCGTCGAATTATTTACGCTTATTTATTAGGAAATAATGATCTTCACTTACGCA
ATTTTTCATTTATTTATCCCAAAAACAGTCATCCAAAACTTGCTCCAATTTATGATTTTGTGTCAGTGTCGCCCTATCCT
GAAATATTTAATTCAACACTACTTGCCTTGCCATTGTTAGTGCGAGAAGAGGGTAATGCCACACTAGCCAAAGGATTTAA
TACTCAATACGGTGAATATATCGGCGATGATTTTGTCGAGTTTGGGGAAAATATTGGATTAAATAAAAATGTGATTATTC
AAAAATTAATTCCTGAAATTACACAAGAAAAGGAAAAAGTAGAGCAGATTTATTCACAATCCTTTATGCCGCAGCCACAT
ATTGATTGCGTGCTGAAAACTTATCGCAAGCGTTTAGCTTTGCTTAACCTATTAAATGAACCTGAACTATAA

Antitoxin


Download         Length: 107 a.a.        Molecular weight: 12433.09 Da        Isoelectric Point: 6.2114

>AT73719 WP_048954894.1 NZ_CP020010:c719428-719108 [Haemophilus influenzae]
MRNLVRSGKVFLYGEFIGLLREDHHGFHFSYNPDYQGIPLSLSFPIEQSPFHSDTLFPYFASLVPEGWLKHKYALHQRID
ESDMFRFLLNNGENMLGAVQIQEEKQ

Download         Length: 321 bp

>AT73719 NZ_CP020010:c719428-719108 [Haemophilus influenzae]
ATGCGCAATTTAGTCCGCTCGGGAAAAGTATTTCTCTACGGCGAATTTATTGGCTTACTTAGAGAAGATCATCATGGTTT
TCATTTTTCTTACAACCCCGATTATCAAGGAATACCGCTCTCTCTCAGCTTTCCTATTGAGCAAAGTCCTTTTCATTCTG
ACACCTTATTCCCTTATTTTGCATCGCTCGTCCCAGAAGGCTGGCTAAAACACAAATATGCACTTCATCAACGAATTGAT
GAAAGCGATATGTTTCGCTTTTTACTTAATAACGGGGAAAATATGTTAGGTGCAGTGCAAATTCAGGAAGAAAAACAATG
A

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References