Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 423439..424108 Replicon chromosome
Accession NZ_CP020008
Organism Haemophilus influenzae strain 5P28H1

Toxin (Protein)


Gene name higB Uniprot ID A0A2R3G0F4
Locus tag BV121_RS02090 Protein ID WP_015701504.1
Coordinates 423725..424108 (-) Length 128 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID A0A502K5Z3
Locus tag BV121_RS02085 Protein ID WP_005651224.1
Coordinates 423439..423741 (-) Length 101 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BV121_RS09455 418916..419074 - 159 WP_005651234.1 hypothetical protein -
BV121_RS02070 419402..419734 - 333 WP_038440713.1 phage tail protein -
BV121_RS02075 419743..423135 - 3393 WP_042611832.1 tape measure protein -
BV121_RS02080 423187..423423 - 237 WP_101494098.1 hypothetical protein -
BV121_RS02085 423439..423741 - 303 WP_005651224.1 XRE family transcriptional regulator Antitoxin
BV121_RS02090 423725..424108 - 384 WP_015701504.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
BV121_RS02095 424177..424401 - 225 WP_038440708.1 DUF4035 domain-containing protein -
BV121_RS02100 424446..424853 - 408 WP_038440705.1 hypothetical protein -
BV121_RS02105 425128..425778 - 651 WP_038440702.1 hypothetical protein -
BV121_RS02110 425781..426191 - 411 WP_005651206.1 phage tail protein -
BV121_RS02115 426209..426730 - 522 WP_042593432.1 phage tail protein -
BV121_RS02120 426733..427044 - 312 WP_042611831.1 hypothetical protein -
BV121_RS02125 427025..427348 - 324 WP_042593431.1 DUF2190 family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 407660..453313 45653


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(16-110)

Antitoxin

Cro/C1-type helix-turn-helix domain

(32-81)


Sequences

Toxin        


Download         Length: 128 a.a.        Molecular weight: 14868.05 Da        Isoelectric Point: 4.4987

>T73705 WP_015701504.1 NZ_CP020008:c424108-423725 [Haemophilus influenzae]
MKQEWEVILQDPLLNWLETLAEDDVLKIYAALELLSTEGPQLSRPYADTLQGSKYTNLKELRVQSKLSVFRLFYIFDPVR
QAIVLCGGDKKGKKEKLFYKEMIALAEQTYDDYLSELTKEQENEREI

Download         Length: 384 bp

>T73705 NZ_CP020008:c424108-423725 [Haemophilus influenzae]
ATGAAACAAGAATGGGAAGTAATTTTACAAGACCCACTTTTGAACTGGTTAGAAACGCTGGCAGAAGATGACGTATTAAA
AATCTATGCGGCGTTGGAATTATTATCAACAGAAGGTCCACAATTAAGCAGACCTTATGCGGATACGCTGCAAGGCTCTA
AATATACCAATTTAAAAGAATTGCGAGTACAGTCTAAATTATCGGTATTCCGTTTATTTTATATTTTCGACCCTGTCAGA
CAAGCGATTGTTTTATGTGGCGGAGATAAAAAAGGCAAGAAAGAAAAACTCTTTTACAAAGAGATGATTGCCCTAGCGGA
ACAAACCTATGATGATTACCTTTCTGAATTAACTAAGGAGCAAGAAAATGAGCGTGAAATTTAA

Antitoxin


Download         Length: 101 a.a.        Molecular weight: 11258.21 Da        Isoelectric Point: 9.5655

>AT73705 WP_005651224.1 NZ_CP020008:c423741-423439 [Haemophilus influenzae]
MSVKFKDLMNNLPAEKQAKVKAMADDMRMELQLYRIREELELSQKQMAEALSISQPSVVALEKRGNDIKLSSVKRYIEAM
GGVLNLSVELPTGKTVTFNL

Download         Length: 303 bp

>AT73705 NZ_CP020008:c423741-423439 [Haemophilus influenzae]
ATGAGCGTGAAATTTAAAGATCTGATGAATAATCTTCCAGCTGAAAAGCAAGCGAAAGTGAAAGCTATGGCAGACGATAT
GCGAATGGAGTTACAACTTTACCGTATTCGTGAAGAATTAGAGCTTTCACAAAAGCAAATGGCAGAAGCATTAAGTATTT
CTCAGCCGTCAGTTGTCGCCCTTGAAAAACGTGGCAATGACATTAAATTATCATCAGTTAAACGTTACATTGAAGCAATG
GGTGGTGTGTTAAATTTATCGGTTGAATTACCCACAGGAAAAACAGTTACTTTCAACTTATAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2R3G0F4

Antitoxin

Source ID Structure
AlphaFold DB A0A502K5Z3

References