Detailed information of TA system TA073698

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): HipBST/HipA-HipA
• Location: 765177..766525
• Replicon: chromosome
• Accession: NZ_CP020007
• Organism: Haemophilus influenzae strain 48P153H1

Toxin (Protein)

• Gene name: HipT
• Uniprot ID: -
• Locus tag: BV085_RS03815
• Protein ID: WP_005687924.1
• Coordinates: 765177..766208 (-)
• Length: 344 a.a.

Antitoxin (Protein)

• Gene name: HipS
• Uniprot ID: A0A2R3FM14
• Locus tag: BV085_RS03820
• Protein ID: WP_005687922.1
• Coordinates: 766205..766525 (-)
• Length: 107 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
BV085_RS09185	761169..761324	-	156	WP_105211008.1	PT domain-containing protein	-
BV085_RS03805	761697..763442	+	1746	WP_005687928.1	ABC transporter ATP-binding protein/permease	-
BV085_RS03810	763435..765093	+	1659	WP_005687926.1	thiol reductant ABC exporter subunit CydC	-
BV085_RS03815	765177..766208	-	1032	WP_005687924.1	type II toxin-antitoxin system HipA family toxin	Toxin
BV085_RS03820	766205..766525	-	321	WP_005687922.1	type II toxin-antitoxin system HipA family toxin	Antitoxin
BV085_RS03825	766513..766821	-	309	WP_005661200.1	helix-turn-helix domain-containing protein	-
BV085_RS03830	767021..768022	-	1002	WP_005687920.1	class II fructose-bisphosphatase	-
BV085_RS03835	768184..768402	+	219	WP_005650820.1	cell division protein ZapB	-
BV085_RS03840	768496..768936	+	441	WP_005687918.1	FMN-binding protein MioC	-
BV085_RS03845	768933..769367	+	435	WP_005687917.1	D-tyrosyl-tRNA(Tyr) deacylase	-
BV085_RS03850	769669..770145	-	477	WP_005687916.1	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase	-
BV085_RS03855	770142..770819	-	678	WP_005655267.1	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase	-
BV085_RS03860	770819..771097	-	279	WP_005665661.1	cell division protein FtsB	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HipA-like, C-terminal (56-290)

Antitoxin

• HipA, N-terminal subdomain 1 (9-101)

Sequences

Toxin

Protein

• Length: 344 a.a.
• Molecular weight: 39846.34 Da
• Isoelectric Point: 6.5052

>T73698 WP_005687924.1 NZ_CP020007:c766208-765177 [Haemophilus influenzae]
MNFCRILLKPLKKNEVHSDYSTKGLHYLTGNKHFNPELPFSRQEFITVKPQKQQGMSISGFQPKLQLIIKDGHFDSVNQQ
GNYILKPSPEEYPFLAENEHATMRIMKELGFDVPENGLVSFAGEQNHKEFAFVIKRFDRDEQQTEIHQEQLDGAMNIRDK
YGKIGADNEQYVSYEQIAKFILQHTENHLAQQREIFRRIIYAYLLGNNDLHLRNFSFIYPKNSHPKLAPIYDFVSVSPYP
EIFNSTLLALPLLAREEGNATLAKGFNTQYGEYIGDDFVEFGENIGLNKNVIIQKLIPEITQEKEKVEQVYSQSFMPQPH
IDCVLKTYRKRLTLLNVLNEPEL

Nucleotide

• Length: 1032 bp

>T73698 NZ_CP020007:c766208-765177 [Haemophilus influenzae]
ATGAATTTTTGTCGTATTTTATTAAAGCCATTAAAGAAAAATGAAGTTCATTCTGACTACAGCACAAAAGGTTTACATTA
CCTTACAGGCAATAAACATTTTAATCCTGAATTACCCTTTTCTCGCCAAGAATTTATTACAGTGAAACCCCAAAAACAGC
AAGGAATGAGCATTTCAGGTTTTCAACCAAAATTACAGCTTATTATCAAAGATGGGCACTTTGACAGCGTAAATCAACAG
GGAAATTATATTTTAAAGCCCTCTCCAGAAGAGTATCCTTTTTTAGCTGAAAATGAACACGCCACCATGCGCATTATGAA
AGAATTAGGGTTTGATGTGCCAGAAAATGGTTTAGTTTCTTTTGCTGGCGAACAAAATCATAAGGAATTTGCTTTTGTTA
TAAAGCGTTTTGATCGTGATGAACAACAAACAGAGATTCACCAAGAACAACTTGATGGTGCAATGAATATTCGAGACAAG
TACGGAAAAATAGGTGCAGATAATGAGCAATATGTGAGTTATGAACAAATTGCTAAGTTTATTTTGCAGCACACTGAAAA
TCATTTAGCTCAGCAACGAGAAATTTTTCGTCGAATTATTTACGCTTATTTATTAGGAAATAATGATCTTCACTTACGCA
ATTTTTCATTTATTTATCCCAAAAACAGTCATCCAAAACTTGCTCCAATTTATGACTTTGTGTCGGTGTCGCCCTATCCT
GAAATATTTAATTCAACACTACTTGCTTTGCCATTGTTAGCGCGAGAAGAAGGTAATGCCACACTAGCCAAAGGATTTAA
TACTCAATACGGTGAATATATCGGCGATGATTTTGTCGAGTTTGGGGAAAATATTGGATTAAATAAAAATGTGATTATTC
AAAAATTAATTCCTGAAATTACACAAGAAAAGGAAAAGGTGGAGCAGGTTTATTCACAATCCTTTATGCCGCAACCGCAT
ATTGATTGCGTACTGAAAACTTATCGCAAGCGTTTAACGTTACTTAACGTATTAAATGAACCTGAGCTATAA

Antitoxin

Protein

• Length: 107 a.a.
• Molecular weight: 12407.09 Da
• Isoelectric Point: 5.9670

>AT73698 WP_005687922.1 NZ_CP020007:c766525-766205 [Haemophilus influenzae]
MRDLVRSGKVFLYGEFIGLLREDHRGFHFAYNPDYQGIPLSLSFPIEQSPFHSDTLFPYFASLVPEGWLKHKYALHQRID
EGDMFRFLLNNGENMLGAVQIQEEKQ

Nucleotide

• Length: 321 bp

>AT73698 NZ_CP020007:c766525-766205 [Haemophilus influenzae]
ATGCGCGATTTAGTCCGCTCGGGAAAAGTATTTCTCTACGGCGAATTTATTGGCTTACTTAGAGAAGATCATCGTGGTTT
TCATTTTGCTTACAATCCCGATTATCAAGGAATACCGCTCTCTCTCAGCTTTCCTATTGAGCAAAGCCCTTTTCATTCTG
ACACCTTATTCCCTTATTTTGCATCGCTCGTCCCAGAAGGCTGGCTAAAACACAAATATGCACTTCATCAACGAATTGAT
GAAGGCGATATGTTTCGCTTTTTACTTAATAACGGGGAAAATATGTTAGGTGCAGTGCAAATTCAGGAGGAAAAACAATG
A

Structures

Antitoxin

• AlphaFold DB: A0A2R3FM14