Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) HipBST/HipA-HipA
Location 765329..766677 Replicon chromosome
Accession NZ_CP020006
Organism Haemophilus influenzae strain 48P106H1

Toxin (Protein)


Gene name HipT Uniprot ID -
Locus tag BV083_RS03810 Protein ID WP_005687924.1
Coordinates 765329..766360 (-) Length 344 a.a.

Antitoxin (Protein)


Gene name HipS Uniprot ID A0A2R3FM14
Locus tag BV083_RS03815 Protein ID WP_005687922.1
Coordinates 766357..766677 (-) Length 107 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BV083_RS03800 761849..763594 + 1746 WP_005687928.1 ABC transporter ATP-binding protein/permease -
BV083_RS03805 763587..765245 + 1659 WP_005687926.1 thiol reductant ABC exporter subunit CydC -
BV083_RS03810 765329..766360 - 1032 WP_005687924.1 type II toxin-antitoxin system HipA family toxin Toxin
BV083_RS03815 766357..766677 - 321 WP_005687922.1 type II toxin-antitoxin system HipA family toxin Antitoxin
BV083_RS03820 766665..766973 - 309 WP_005661200.1 helix-turn-helix domain-containing protein -
BV083_RS03825 767173..768174 - 1002 WP_005687920.1 class II fructose-bisphosphatase -
BV083_RS03830 768336..768554 + 219 WP_005650820.1 cell division protein ZapB -
BV083_RS03835 768648..769088 + 441 WP_005687918.1 FMN-binding protein MioC -
BV083_RS03840 769085..769519 + 435 WP_005687917.1 D-tyrosyl-tRNA(Tyr) deacylase -
BV083_RS03845 769821..770297 - 477 WP_005687916.1 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase -
BV083_RS03850 770294..770971 - 678 WP_005655267.1 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase -
BV083_RS03855 770971..771249 - 279 WP_005665661.1 cell division protein FtsB -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(56-290)

Antitoxin

(9-101)


Sequences


Toxin        


Download         Length: 344 a.a.        Molecular weight: 39846.34 Da        Isoelectric Point: 6.5052

>T73689 WP_005687924.1 NZ_CP020006:c766360-765329 [Haemophilus influenzae]
MNFCRILLKPLKKNEVHSDYSTKGLHYLTGNKHFNPELPFSRQEFITVKPQKQQGMSISGFQPKLQLIIKDGHFDSVNQQ
GNYILKPSPEEYPFLAENEHATMRIMKELGFDVPENGLVSFAGEQNHKEFAFVIKRFDRDEQQTEIHQEQLDGAMNIRDK
YGKIGADNEQYVSYEQIAKFILQHTENHLAQQREIFRRIIYAYLLGNNDLHLRNFSFIYPKNSHPKLAPIYDFVSVSPYP
EIFNSTLLALPLLAREEGNATLAKGFNTQYGEYIGDDFVEFGENIGLNKNVIIQKLIPEITQEKEKVEQVYSQSFMPQPH
IDCVLKTYRKRLTLLNVLNEPEL

Download         Length: 1032 bp

>T73689 NZ_CP020006:c766360-765329 [Haemophilus influenzae]
ATGAATTTTTGTCGTATTTTATTAAAGCCATTAAAGAAAAATGAAGTTCATTCTGACTACAGCACAAAAGGTTTACATTA
CCTTACAGGCAATAAACATTTTAATCCTGAATTACCCTTTTCTCGCCAAGAATTTATTACAGTGAAACCCCAAAAACAGC
AAGGAATGAGCATTTCAGGTTTTCAACCAAAATTACAGCTTATTATCAAAGATGGGCACTTTGACAGCGTAAATCAACAG
GGAAATTATATTTTAAAGCCCTCTCCAGAAGAGTATCCTTTTTTAGCTGAAAATGAACACGCCACCATGCGCATTATGAA
AGAATTAGGGTTTGATGTGCCAGAAAATGGTTTAGTTTCTTTTGCTGGCGAACAAAATCATAAGGAATTTGCTTTTGTTA
TAAAGCGTTTTGATCGTGATGAACAACAAACAGAGATTCACCAAGAACAACTTGATGGTGCAATGAATATTCGAGACAAG
TACGGAAAAATAGGTGCAGATAATGAGCAATATGTGAGTTATGAACAAATTGCTAAGTTTATTTTGCAGCACACTGAAAA
TCATTTAGCTCAGCAACGAGAAATTTTTCGTCGAATTATTTACGCTTATTTATTAGGAAATAATGATCTTCACTTACGCA
ATTTTTCATTTATTTATCCCAAAAACAGTCATCCAAAACTTGCTCCAATTTATGACTTTGTGTCGGTGTCGCCCTATCCT
GAAATATTTAATTCAACACTACTTGCTTTGCCATTGTTAGCGCGAGAAGAAGGTAATGCCACACTAGCCAAAGGATTTAA
TACTCAATACGGTGAATATATCGGCGATGATTTTGTCGAGTTTGGGGAAAATATTGGATTAAATAAAAATGTGATTATTC
AAAAATTAATTCCTGAAATTACACAAGAAAAGGAAAAGGTGGAGCAGGTTTATTCACAATCCTTTATGCCGCAACCGCAT
ATTGATTGCGTACTGAAAACTTATCGCAAGCGTTTAACGTTACTTAACGTATTAAATGAACCTGAGCTATAA

Antitoxin


Download         Length: 107 a.a.        Molecular weight: 12407.09 Da        Isoelectric Point: 5.9670

>AT73689 WP_005687922.1 NZ_CP020006:c766677-766357 [Haemophilus influenzae]
MRDLVRSGKVFLYGEFIGLLREDHRGFHFAYNPDYQGIPLSLSFPIEQSPFHSDTLFPYFASLVPEGWLKHKYALHQRID
EGDMFRFLLNNGENMLGAVQIQEEKQ

Download         Length: 321 bp

>AT73689 NZ_CP020006:c766677-766357 [Haemophilus influenzae]
ATGCGCGATTTAGTCCGCTCGGGAAAAGTATTTCTCTACGGCGAATTTATTGGCTTACTTAGAGAAGATCATCGTGGTTT
TCATTTTGCTTACAATCCCGATTATCAAGGAATACCGCTCTCTCTCAGCTTTCCTATTGAGCAAAGCCCTTTTCATTCTG
ACACCTTATTCCCTTATTTTGCATCGCTCGTCCCAGAAGGCTGGCTAAAACACAAATATGCACTTCATCAACGAATTGAT
GAAGGCGATATGTTTCGCTTTTTACTTAATAACGGGGAAAATATGTTAGGTGCAGTGCAAATTCAGGAGGAAAAACAATG
A

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure


Antitoxin

Source ID Structure
AlphaFold DB A0A2R3FM14

References