Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 5048552..5048982 Replicon chromosome
Accession NZ_CP019998
Organism Arthrospira platensis C1

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag APLC1_RS23990 Protein ID WP_081587642.1
Coordinates 5048869..5048982 (-) Length 38 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag APLC1_RS23985 Protein ID WP_260378380.1
Coordinates 5048552..5048836 (-) Length 95 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
APLC1_RS23955 5044035..5044202 - 168 WP_006621079.1 hypothetical protein -
APLC1_RS23960 (APLC1_5186) 5044221..5046134 + 1914 WP_006621080.1 transketolase C-terminal domain-containing protein -
APLC1_RS23965 (APLC1_5187) 5046252..5047082 - 831 WP_006621081.1 PEP-CTERM sorting domain-containing protein -
APLC1_RS23970 (APLC1_5188) 5047369..5047721 - 353 Protein_4754 dihydroneopterin aldolase -
APLC1_RS23980 5048334..5048489 - 156 WP_155839082.1 hypothetical protein -
APLC1_RS23985 (APLC1_5190) 5048552..5048836 - 285 WP_260378380.1 HigA family addiction module antitoxin Antitoxin
APLC1_RS23990 5048869..5048982 - 114 WP_081587642.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
APLC1_RS23995 (APLC1_5191) 5049111..5049689 - 579 WP_046319903.1 restriction endonuclease subunit S -
APLC1_RS24000 (APLC1_5192) 5049686..5050156 - 471 WP_006621086.1 PDDEXK nuclease domain-containing protein -
APLC1_RS24005 (APLC1_5193) 5050267..5051433 - 1167 WP_006621087.1 Na/Pi symporter -
APLC1_RS24010 (APLC1_5194) 5051644..5052696 + 1053 WP_048894950.1 IS630-like element ISAtsp4 family transposase -
APLC1_RS24015 5052735..5053744 + 1010 Protein_4762 IS630-like element ISAtsp4 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(7-37)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(1-86)


Sequences

Toxin        


Download         Length: 38 a.a.        Molecular weight: 4344.85 Da        Isoelectric Point: 4.6700

>T73680 WP_081587642.1 NZ_CP019998:c5048982-5048869 [Arthrospira platensis C1]
MVGSRIGQYSIRINDQWRICFGWKDGDATDVEIVDYH

Download         Length: 114 bp

>T73680 NZ_CP019998:c5048982-5048869 [Arthrospira platensis C1]
TTGGTAGGCAGTAGAATCGGTCAGTATAGTATCCGAATTAATGACCAATGGAGAATTTGCTTTGGGTGGAAAGATGGGGA
TGCAACAGATGTAGAAATTGTTGACTATCACTGA

Antitoxin


Download         Length: 95 a.a.        Molecular weight: 10851.62 Da        Isoelectric Point: 6.4605

>AT73680 WP_260378380.1 NZ_CP019998:c5048836-5048552 [Arthrospira platensis C1]
MTPVHPGEVLLEEFLKPMNLSQNQVALALRVPARRINEIIHGKRRITADTALRLAYYFNMSARFWMGLQMDYDLDVAEDA
LGEKLKMEVCSRQD

Download         Length: 285 bp

>AT73680 NZ_CP019998:c5048836-5048552 [Arthrospira platensis C1]
TTGACCCCTGTACATCCTGGCGAAGTCCTGTTAGAAGAATTTCTCAAGCCCATGAATCTGAGTCAAAATCAGGTTGCTCT
AGCCTTGCGTGTACCTGCACGTCGAATTAATGAAATTATTCACGGTAAACGTAGAATTACGGCAGATACAGCCCTACGTT
TAGCCTATTATTTCAATATGTCCGCCCGGTTTTGGATGGGTTTGCAAATGGATTATGATCTGGATGTAGCTGAAGATGCA
CTCGGAGAAAAATTAAAAATGGAAGTTTGTTCCCGGCAAGACTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References