Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 1418968..1419399 Replicon chromosome
Accession NZ_CP019998
Organism Arthrospira platensis C1

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag APLC1_RS07030 Protein ID WP_081587642.1
Coordinates 1418968..1419081 (+) Length 38 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag APLC1_RS07035 Protein ID WP_006623772.1
Coordinates 1419091..1419399 (+) Length 103 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
APLC1_RS07000 1414032..1414909 + 878 Protein_1391 IS630 family transposase -
APLC1_RS07005 (APLC1_1496) 1414960..1415220 + 261 WP_006623765.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein -
APLC1_RS07010 1415242..1415511 + 270 WP_006623767.1 type II toxin-antitoxin system PemK/MazF family toxin -
APLC1_RS07015 (APLC1_1497) 1415681..1417222 + 1542 WP_006623768.1 type I restriction-modification system subunit M -
APLC1_RS07020 (APLC1_1498) 1417219..1418273 + 1055 Protein_1395 PDDEXK nuclease domain-containing protein -
APLC1_RS07025 (APLC1_1500) 1418270..1418839 + 570 WP_231296326.1 restriction endonuclease subunit S -
APLC1_RS07030 1418968..1419081 + 114 WP_081587642.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
APLC1_RS07035 (APLC1_1501) 1419091..1419399 + 309 WP_006623772.1 HigA family addiction module antitoxin Antitoxin
APLC1_RS07040 (APLC1_1502) 1419462..1422557 + 3096 WP_006623773.1 type I restriction endonuclease subunit R -
APLC1_RS07045 (APLC1_1503) 1422836..1423126 + 291 WP_006623774.1 nucleotidyltransferase family protein -
APLC1_RS07050 (APLC1_1504) 1423827..1424075 + 249 WP_006623775.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(7-37)

Antitoxin

Cro/C1-type helix-turn-helix domain

(19-71)


Sequences

Toxin        


Download         Length: 38 a.a.        Molecular weight: 4344.85 Da        Isoelectric Point: 4.6700

>T73678 WP_081587642.1 NZ_CP019998:1418968-1419081 [Arthrospira platensis C1]
MVGSRIGQYSIRINDQWRICFGWKDGDATDVEIVDYH

Download         Length: 114 bp

>T73678 NZ_CP019998:1418968-1419081 [Arthrospira platensis C1]
TTGGTAGGCAGTAGAATCGGTCAGTATAGTATCCGAATTAATGACCAATGGAGAATTTGCTTTGGGTGGAAAGATGGGGA
TGCAACAGATGTAGAAATTGTTGACTATCACTGA

Antitoxin


Download         Length: 103 a.a.        Molecular weight: 11792.76 Da        Isoelectric Point: 8.0262

>AT73678 WP_006623772.1 NZ_CP019998:1419091-1419399 [Arthrospira platensis C1]
MTKNKLDKLTPVHPGEVLLEEFLKPMNLSQNQVALALRVPARRINEIIHGKRRITADTALRLAYYFNMSARFWMGLQMDY
DLDVAEDAIGEKLKMEVCSRQD

Download         Length: 309 bp

>AT73678 NZ_CP019998:1419091-1419399 [Arthrospira platensis C1]
ATGACAAAAAATAAATTAGATAAATTGACCCCTGTACATCCTGGCGAAGTCCTGTTAGAAGAATTTCTCAAGCCCATGAA
TCTGAGTCAAAATCAGGTTGCTCTAGCCTTGCGTGTACCTGCACGTCGAATTAATGAAATTATTCACGGTAAACGTAGAA
TTACGGCAGATACAGCCCTACGTTTAGCCTATTATTTCAATATGTCCGCCCGGTTTTGGATGGGTTTGCAAATGGATTAT
GATCTGGATGTAGCTGAAGATGCAATCGGAGAAAAATTAAAAATGGAAGTTTGTTCCCGGCAAGACTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References