Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-RelB
Location 1918279..1918792 Replicon chromosome
Accession NZ_CP019979
Organism Streptococcus agalactiae strain Sag158

Toxin (Protein)


Gene name yoeB Uniprot ID Q8DX49
Locus tag B2G84_RS10050 Protein ID WP_000481712.1
Coordinates 1918279..1918533 (-) Length 85 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID Q8DX48
Locus tag B2G84_RS10055 Protein ID WP_000387490.1
Coordinates 1918526..1918792 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
B2G84_RS10030 1914051..1916552 - 2502 WP_000239405.1 ATP-binding protein -
B2G84_RS10035 1916573..1916983 - 411 WP_000390748.1 conjugal transfer protein -
B2G84_RS10040 1916987..1917253 - 267 WP_001055036.1 hypothetical protein -
B2G84_RS10045 1917273..1918226 - 954 WP_000565542.1 conjugal transfer protein -
B2G84_RS10050 1918279..1918533 - 255 WP_000481712.1 Txe/YoeB family addiction module toxin Toxin
B2G84_RS10055 1918526..1918792 - 267 WP_000387490.1 type II toxin-antitoxin system prevent-host-death family antitoxin Antitoxin
B2G84_RS10060 1918937..1919410 - 474 WP_000560386.1 hypothetical protein -
B2G84_RS10065 1919418..1919900 - 483 WP_000383282.1 antirestriction protein ArdA -
B2G84_RS10070 1919952..1920224 - 273 WP_000072642.1 hypothetical protein -
B2G84_RS10075 1920356..1920709 - 354 WP_000571928.1 helix-turn-helix domain-containing protein -
B2G84_RS10080 1920702..1920917 - 216 WP_001897988.1 helix-turn-helix domain-containing protein -
B2G84_RS10085 1920901..1921278 - 378 WP_000287184.1 hypothetical protein -
B2G84_RS10090 1921294..1922526 - 1233 WP_000338839.1 replication initiation factor domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - - 1905084..1943995 38911


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(4-83)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-73)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 10445.87 Da        Isoelectric Point: 6.7282

>T73647 WP_000481712.1 NZ_CP019979:c1918533-1918279 [Streptococcus agalactiae]
MFNFTEEAWKDYVSWQQEDKKILKRINRLIEDIKRDPFEGIGKPEPLKYHYSGAWSRRITEEHRLIYMIEDGEIYFLSFR
DHYK

Download         Length: 255 bp

>T73647 NZ_CP019979:c1918533-1918279 [Streptococcus agalactiae]
ATGTTTAATTTTACTGAAGAAGCATGGAAAGATTATGTTTCTTGGCAACAGGAAGATAAAAAAATCTTGAAACGAATTAA
TCGTTTGATAGAAGATATTAAAAGAGACCCATTTGAAGGCATTGGAAAACCAGAACCTTTAAAATACCATTATTCAGGGG
CTTGGTCTCGAAGAATTACAGAAGAACATAGGTTGATTTATATGATAGAAGATGGAGAAATCTATTTTTTATCTTTTAGA
GATCATTATAAGTAG

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10316.70 Da        Isoelectric Point: 4.6742

>AT73647 WP_000387490.1 NZ_CP019979:c1918792-1918526 [Streptococcus agalactiae]
MEAIVYSHFRNNLKDYMKKVNDEFEPLIVVNKNPDENIVVLSQDSWESLQETIRLMENDYLSHKVINGISQVKEKQVTKH
GLIEVEDV

Download         Length: 267 bp

>AT73647 NZ_CP019979:c1918792-1918526 [Streptococcus agalactiae]
ATGGAGGCTATTGTTTATTCACATTTTAGAAATAATTTAAAAGATTATATGAAGAAGGTCAATGATGAATTTGAGCCTTT
GATTGTAGTTAATAAAAATCCTGATGAAAATATAGTGGTTTTATCTCAAGATAGCTGGGAAAGTTTACAAGAAACGATTC
GTTTGATGGAAAATGATTATCTATCACATAAGGTTATTAATGGTATATCACAAGTTAAAGAGAAGCAAGTCACTAAACAT
GGTTTAATTGAGGTAGAAGATGTTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829IC12

Antitoxin

Source ID Structure
AlphaFold DB A0A829I9V6

References