Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/VapI(antitoxin)
Location 68302..69730 Replicon chromosome
Accession NZ_CP019969
Organism Dehalococcoides mccartyi strain KBVC2

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag B1776_RS00370 Protein ID WP_058316891.1
Coordinates 68302..68640 (+) Length 113 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag B1776_RS00375 Protein ID WP_058316890.1
Coordinates 68633..69730 (+) Length 366 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
B1776_RS00340 64871..65206 - 336 WP_011928612.1 hypothetical protein -
B1776_RS00345 65262..65654 - 393 WP_011928613.1 single-stranded DNA-binding protein -
B1776_RS00350 65695..65937 - 243 WP_153300901.1 hypothetical protein -
B1776_RS00355 66118..66750 + 633 WP_078986738.1 LexA family transcriptional regulator -
B1776_RS00360 66901..67383 + 483 WP_078986739.1 hypothetical protein -
B1776_RS00365 67407..68180 + 774 WP_058316892.1 hypothetical protein -
B1776_RS00370 68302..68640 + 339 WP_058316891.1 hypothetical protein Toxin
B1776_RS00375 68633..69730 + 1098 WP_058316890.1 HigA family addiction module antidote protein Antitoxin
B1776_RS00380 70294..70602 - 309 WP_011308733.1 rubrerythrin -
B1776_RS00385 70791..71936 - 1146 WP_061977017.1 NTP transferase domain-containing protein -
B1776_RS00390 71937..72626 - 690 WP_078986740.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - - 57606..69924 12318


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(16-89)


Sequences

Toxin        


Download         Length: 113 a.a.        Molecular weight: 12816.04 Da        Isoelectric Point: 8.8488

>T73635 WP_058316891.1 NZ_CP019969:68302-68640 [Dehalococcoides mccartyi]
MDIIFCNRKLASIFNSEKNLKIAYGPENCKKIMNRMAVLKAAYCLDEIPVKPPERRHELKGDRKGQLAVDLKHPCRLIFR
PTSNPLPLKTDGGLDLRSVKGIEILEVEDYHE

Download         Length: 339 bp

>T73635 NZ_CP019969:68302-68640 [Dehalococcoides mccartyi]
ATGGATATTATCTTTTGCAATAGGAAACTCGCAAGTATATTCAATAGTGAGAAAAATCTGAAGATAGCGTATGGCCCTGA
AAATTGCAAGAAGATTATGAATAGAATGGCTGTATTAAAAGCGGCCTACTGTCTTGATGAGATACCTGTAAAACCCCCTG
AGCGTAGACATGAGCTTAAAGGTGACAGGAAAGGACAATTAGCAGTTGACCTCAAACATCCCTGTCGGCTTATATTCCGA
CCCACTAGTAATCCTCTGCCCCTAAAGACTGATGGGGGCTTAGATCTTAGGAGCGTAAAAGGAATAGAAATTTTAGAAGT
TGAGGATTATCATGAGTAA

Antitoxin


Download         Length: 366 a.a.        Molecular weight: 41295.39 Da        Isoelectric Point: 6.3981

>AT73635 WP_058316890.1 NZ_CP019969:68633-69730 [Dehalococcoides mccartyi]
MSNTKLYRYEPDYVAVPGEILEENLEAQNIKKVDLASRCGLSTKTISQIINGTASISPETALGFQKVLGVSANIWLNLEA
DYRLFLAQQDLYKRLSKSGAWLNKFPIKELINKGFIEAKESIAEKTDQLLVFFGVSDIESWELSYNKLEVAFRHSPSFKS
LPEAIATWLRIGEICAAKVKCKPFDKSQFSEALNAIRILTPEEPKIFEPRLKEMCAEAGVALVFLEELPGMHLSGATRWI
TKDKALIMLSLRHKSDDHFWFSFFHEAGHILSGGKKSIFLDESNSWEDPEEDQANNFASDLLIPKQEYESFLKDGKFTSS
SVTCFAQNLGIAPGIVVGRLQHEQVIGWNSLYRLKRRFRLVEVCS

Download         Length: 1098 bp

>AT73635 NZ_CP019969:68633-69730 [Dehalococcoides mccartyi]
ATGAGTAATACAAAATTATATAGATATGAACCTGATTATGTTGCAGTTCCGGGCGAGATATTAGAAGAAAACCTTGAGGC
TCAAAATATCAAAAAAGTTGATTTGGCTTCAAGATGTGGTTTAAGCACTAAAACTATTAGTCAAATCATAAATGGTACTG
CATCAATTTCTCCGGAAACAGCCTTGGGTTTTCAAAAAGTACTTGGTGTTTCCGCCAATATTTGGCTTAATCTTGAGGCA
GATTATAGATTATTCCTGGCGCAACAAGATCTGTATAAGAGACTATCTAAGTCTGGTGCATGGCTTAACAAGTTTCCTAT
TAAAGAACTCATTAATAAAGGGTTTATAGAAGCTAAAGAAAGTATTGCTGAAAAAACAGACCAATTGCTTGTATTTTTCG
GAGTAAGCGACATAGAATCTTGGGAATTAAGCTATAACAAGTTGGAAGTTGCATTTAGGCATTCTCCTTCATTTAAAAGT
TTGCCAGAAGCTATTGCTACATGGTTAAGAATTGGAGAAATCTGCGCTGCAAAAGTGAAATGTAAACCCTTTGATAAATC
TCAATTTTCAGAGGCACTCAACGCTATACGCATCCTTACTCCTGAAGAACCAAAGATTTTTGAGCCCCGCTTGAAAGAAA
TGTGTGCAGAAGCCGGTGTTGCCTTGGTATTTCTAGAGGAATTACCTGGTATGCATTTGAGTGGTGCAACGCGATGGATA
ACGAAAGATAAAGCATTAATAATGCTTAGTCTTAGACATAAAAGTGATGACCATTTCTGGTTTAGTTTTTTTCATGAAGC
TGGTCATATATTATCTGGTGGCAAGAAGAGTATATTCCTCGATGAATCAAATTCATGGGAAGATCCCGAAGAAGATCAAG
CAAACAATTTTGCTTCCGATCTATTGATACCCAAACAGGAATATGAGTCTTTTTTAAAAGACGGTAAGTTCACATCATCT
TCTGTCACATGCTTTGCACAAAATTTGGGAATTGCGCCCGGAATAGTTGTAGGACGTTTACAACACGAACAAGTTATTGG
ATGGAATTCTTTGTATCGCTTAAAAAGGAGATTTAGATTGGTTGAGGTTTGTAGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References