Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mqsRA (relBE)/MqsR-MqsA
Location 2497386..2498079 Replicon chromosome
Accession NZ_CP019961
Organism Escherichia coli strain HKUOPY1

Toxin (Protein)


Gene name mqsR Uniprot ID S1EZG2
Locus tag B2J87_RS12885 Protein ID WP_000415584.1
Coordinates 2497386..2497682 (+) Length 99 a.a.

Antitoxin (Protein)


Gene name mqsA Uniprot ID S1EBV2
Locus tag B2J87_RS12890 Protein ID WP_000650107.1
Coordinates 2497684..2498079 (+) Length 132 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
B2J87_RS12845 2492474..2492788 - 315 WP_089623762.1 antibiotic biosynthesis monooxygenase -
B2J87_RS12850 2492819..2493400 - 582 WP_077492296.1 NADPH:quinone oxidoreductase MdaB -
B2J87_RS12860 2493719..2494051 + 333 WP_000917684.1 DUF2645 family protein -
B2J87_RS12865 2494097..2495446 - 1350 WP_000673402.1 two-component system sensor histidine kinase QseC -
B2J87_RS12870 2495443..2496102 - 660 WP_001221493.1 two-component system response regulator QseB -
B2J87_RS12875 2496254..2496646 + 393 WP_001401138.1 OB fold stress tolerance protein YgiW -
B2J87_RS12880 2496699..2497181 + 483 WP_000183505.1 transcriptional regulator -
B2J87_RS12885 2497386..2497682 + 297 WP_000415584.1 type II toxin-antitoxin system toxin MqsR Toxin
B2J87_RS12890 2497684..2498079 + 396 WP_000650107.1 type II toxin-antitoxin system antitoxin MqsA Antitoxin
B2J87_RS12900 2498212..2499818 + 1607 Protein_2314 ABC transporter substrate-binding protein -
B2J87_RS12905 2499956..2502214 + 2259 WP_001281881.1 DNA topoisomerase IV subunit A -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase toxin MqsR

(5-97)

Antitoxin

Zinc finger, MqsA-type

(3-47)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11231.96 Da        Isoelectric Point: 8.9070

>T73611 WP_000415584.1 NZ_CP019961:2497386-2497682 [Escherichia coli]
MEKRTPHTRLSQVKKLVNAGQVRTTRSALLNADELGLDFDGMCNVIIGLSESDFYKSMTTYSDHTIWQDVYRPRLVTGQV
YLKITVIHDVLIVSFKEK

Download         Length: 297 bp

>T73611 NZ_CP019961:2497386-2497682 [Escherichia coli]
ATGGAAAAACGCACACCACATACACGTTTGAGTCAGGTTAAAAAACTTGTCAATGCCGGGCAAGTTCGTACAACACGTAG
TGCACTGTTAAATGCAGATGAGTTAGGTTTGGATTTTGATGGTATGTGTAATGTTATCATTGGATTATCAGAGAGCGACT
TTTATAAAAGCATGACCACCTACTCTGATCATACTATCTGGCAGGATGTTTACAGACCCAGGCTTGTTACAGGCCAGGTT
TATCTTAAAATTACGGTAATTCATGACGTACTGATCGTCTCGTTTAAGGAGAAGTAA

Antitoxin


Download         Length: 132 a.a.        Molecular weight: 14703.10 Da        Isoelectric Point: 9.2136

>AT73611 WP_000650107.1 NZ_CP019961:2497684-2498079 [Escherichia coli]
MKCPVCHQGEMVSGIKDIPYTFRGRKTVLKGIHGLYCVHCEESIMNKEESDAFMAQVKAFRASVNAETVAPEFIVKVRKK
LSLTQKEASEIFGGGVNAFSRYEKGNAQPHPSTIKLLRVLDKHPELLNEIR

Download         Length: 396 bp

>AT73611 NZ_CP019961:2497684-2498079 [Escherichia coli]
ATGAAATGTCCGGTTTGCCACCAGGGAGAAATGGTTTCTGGCATTAAAGATATTCCATACACCTTCCGTGGACGAAAAAC
AGTATTGAAAGGTATCCACGGTTTATATTGTGTCCATTGCGAAGAGAGCATCATGAATAAAGAAGAGTCAGATGCTTTCA
TGGCGCAAGTAAAGGCATTTCGGGCTTCGGTGAATGCCGAAACAGTGGCACCTGAATTTATAGTGAAGGTTCGAAAAAAG
CTCTCTCTTACCCAAAAAGAGGCAAGCGAAATTTTTGGGGGAGGTGTAAATGCGTTTTCGCGTTACGAAAAAGGCAATGC
CCAACCTCATCCTTCCACAATCAAACTTTTACGTGTTCTGGATAAGCATCCAGAACTATTGAATGAAATCCGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 3HI2

Antitoxin

Source ID Structure
PDB 3HI2
PDB 3GA8
PDB 3O9X
PDB 2KZ8
PDB 3FMY
PDB 3GN5
AlphaFold DB A0A7U9LU65

References