Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) hok-sok/-
Location 141401..141665 Replicon plasmid unnamed1
Accession NZ_CP019954
Organism Escherichia coli M8

Toxin (Protein)


Gene name pndA Uniprot ID U9Y6M3
Locus tag B2H83_RS26180 Protein ID WP_001331364.1
Coordinates 141513..141665 (+) Length 51 a.a.

Antitoxin (RNA)


Gene name pndB
Locus tag -
Coordinates 141401..141458 (-)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
B2H83_RS26165 136640..138931 - 2292 WP_129542156.1 conjugal transfer protein TrbC -
B2H83_RS26170 138924..139994 - 1071 WP_052974687.1 IncI1-type conjugal transfer protein TrbB -
B2H83_RS26175 140013..141221 - 1209 WP_129542157.1 IncI1-type conjugal transfer protein TrbA -
- 141401..141458 - 58 NuclAT_0 - Antitoxin
- 141401..141458 - 58 NuclAT_0 - Antitoxin
- 141401..141458 - 58 NuclAT_0 - Antitoxin
- 141401..141458 - 58 NuclAT_0 - Antitoxin
B2H83_RS26180 141513..141665 + 153 WP_001331364.1 Hok/Gef family protein Toxin
B2H83_RS26185 141737..141988 - 252 WP_001291965.1 hypothetical protein -
B2H83_RS26190 142288..142584 + 297 WP_001275298.1 hypothetical protein -
B2H83_RS26565 142649..142825 - 177 WP_001054898.1 hypothetical protein -
B2H83_RS26195 143217..143426 + 210 WP_000062603.1 HEAT repeat domain-containing protein -
B2H83_RS26570 143498..144147 - 650 Protein_159 plasmid IncI1-type surface exclusion protein ExcA -
B2H83_RS26205 144221..146389 - 2169 WP_129542158.1 DotA/TraY family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid - - 1..160021 160021


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Hok/gef cell toxic protein

(7-46)


Sequences

Toxin        


Download         Length: 51 a.a.        Molecular weight: 5775.13 Da        Isoelectric Point: 8.7948

>T73597 WP_001331364.1 NZ_CP019954:141513-141665 [Escherichia coli M8]
MPQRTFLMMLIVICVTILCFVWMVRDSLCGLRLQQGNTVLVATLAYEVKR

Download         Length: 153 bp

>T73597 NZ_CP019954:141513-141665 [Escherichia coli M8]
ATGCCACAGCGAACGTTTTTAATGATGTTAATCGTCATCTGTGTGACGATTCTGTGTTTTGTCTGGATGGTGAGGGATTC
GCTTTGCGGACTCCGGCTCCAGCAGGGAAACACAGTGCTTGTGGCAACGTTAGCCTACGAAGTTAAACGTTAA

Antitoxin


Download         Length: 58 bp

>AT73597 NZ_CP019954:c141458-141401 [Escherichia coli M8]
GCATTACAGTAGAGCCCTTGGTTGATTGATAAAAAAATCTCCAGGGGCTTTCTGCTGT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A5W9M382

Antitoxin

Download structure file

References