Detailed information of TA system TA073555

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): yefM-yoeB (relBE)/Txe-RelB
• Location: 2604093..2604616
• Replicon: chromosome
• Accession: NZ_CP019945
• Organism: Staphylococcus aureus strain BA01611

Toxin (Protein)

• Gene name: yoeB
• Uniprot ID: T1YCD0
• Locus tag: AOZ05_RS13810
• Protein ID: WP_000074043.1
• Coordinates: 2604093..2604359 (-)
• Length: 89 a.a.

Antitoxin (Protein)

• Gene name: yefM
• Uniprot ID: T1YBB2
• Locus tag: AOZ05_RS13815
• Protein ID: WP_000587618.1
• Coordinates: 2604359..2604616 (-)
• Length: 86 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
AOZ05_RS13790	2599650..2600426	-	777	WP_000072147.1	iron export ABC transporter permease subunit FetB	-
AOZ05_RS13795	2600419..2601081	-	663	WP_000923524.1	ATP-binding cassette domain-containing protein	-
AOZ05_RS13800	2601329..2602405	-	1077	WP_001076673.1	M42 family metallopeptidase	-
AOZ05_RS13805	2602674..2603846	-	1173	WP_000195429.1	IS256-like element IS256 family transposase	-
AOZ05_RS13810	2604093..2604359	-	267	WP_000074043.1	Txe/YoeB family addiction module toxin	Toxin
AOZ05_RS13815	2604359..2604616	-	258	WP_000587618.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
AOZ05_RS13825	2604975..2605430	+	456	WP_000732076.1	DUF1307 domain-containing protein	-
AOZ05_RS13830	2605598..2607175	-	1578	WP_000143503.1	FMN-binding glutamate synthase family protein	-
AOZ05_RS13835	2607370..2608119	+	750	WP_000072466.1	hypothetical protein	-
AOZ05_RS13840	2608350..2609543	-	1194	WP_000675407.1	MFS transporter	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	flank	IS/Tn	-	-	2602674..2603846	1172

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin YoeB (4-87)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-68)

Sequences

Toxin

Protein

• Length: 89 a.a.
• Molecular weight: 10657.45 Da
• Isoelectric Point: 10.3584

>T73555 WP_000074043.1 NZ_CP019945:c2604359-2604093 [Staphylococcus aureus]
MSNYTVKIKNSAKLDLKKIKHPYLKKTFIEIVETLKNNPYKITQSFEKLEPKYLERYSRRINLQHRVVYTIDDRNKVVLI
LSAWSHYD

Nucleotide

• Length: 267 bp

>T73555 NZ_CP019945:c2604359-2604093 [Staphylococcus aureus]
ATGAGCAATTACACGGTTAAGATTAAAAATTCGGCGAAGTTAGATTTAAAGAAAATAAAACATCCTTATTTAAAGAAGAC
ATTTATAGAAATTGTTGAGACTTTAAAAAATAATCCTTATAAAATAACACAATCCTTTGAAAAATTAGAACCTAAATATT
TAGAGCGATATTCAAGAAGAATTAACCTTCAGCACAGGGTCGTCTATACCATAGATGATCGAAATAAAGTAGTATTAATA
CTATCGGCATGGTCACATTATGATTAA

Antitoxin

Protein

• Length: 86 a.a.
• Molecular weight: 9762.78 Da
• Isoelectric Point: 4.1958

>AT73555 WP_000587618.1 NZ_CP019945:c2604616-2604359 [Staphylococcus aureus]
MIITSPTEARKDFYQLLKNVNNNHEPIYISGNNAENNAVIIGLEDWKSIQETMYLVSTGTMDKVREREKDNSGTTNIDDI
DWDNL

Nucleotide

• Length: 258 bp

>AT73555 NZ_CP019945:c2604616-2604359 [Staphylococcus aureus]
ATGATTATCACTAGCCCTACAGAAGCGAGAAAAGATTTTTATCAATTACTAAAAAATGTTAATAATAATCACGAACCAAT
TTATATTAGTGGTAATAATGCCGAAAATAATGCTGTGATTATAGGTTTAGAAGATTGGAAAAGTATACAAGAGACAATGT
ATCTTGTATCTACTGGTACAATGGACAAAGTAAGAGAAAGAGAAAAAGATAATAGTGGTACAACAAATATAGATGATATT
GATTGGGATAATCTTTAA

Structures

Toxin

• AlphaFold DB: T1YCD0

Antitoxin

• AlphaFold DB: T1YBB2