Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 2545805..2546322 Replicon chromosome
Accession NZ_CP019945
Organism Staphylococcus aureus strain BA01611

Toxin (Protein)


Gene name yoeB Uniprot ID T1YC79
Locus tag AOZ05_RS13465 Protein ID WP_000113262.1
Coordinates 2545805..2546071 (-) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID T1YB60
Locus tag AOZ05_RS13470 Protein ID WP_000584499.1
Coordinates 2546071..2546322 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AOZ05_RS13440 2541230..2541766 - 537 WP_031585827.1 GNAT family N-acetyltransferase -
AOZ05_RS13445 2541999..2542823 - 825 WP_000572040.1 formate/nitrite transporter family protein -
AOZ05_RS13450 2543040..2543222 - 183 WP_054249653.1 hypothetical protein -
AOZ05_RS13455 2543306..2543773 - 468 WP_000153344.1 SRPBCC domain-containing protein -
AOZ05_RS13460 2543959..2545509 - 1551 WP_000727763.1 zinc ABC transporter substrate-binding lipoprotein AdcA -
AOZ05_RS13465 2545805..2546071 - 267 WP_000113262.1 Txe/YoeB family addiction module toxin Toxin
AOZ05_RS13470 2546071..2546322 - 252 WP_000584499.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
AOZ05_RS13475 2546487..2546588 - 102 WP_031774922.1 hypothetical protein -
AOZ05_RS13480 2546595..2547194 - 600 WP_000162813.1 DsbA family protein -
AOZ05_RS13485 2547213..2547575 - 363 WP_000819843.1 DUF4467 domain-containing protein -
AOZ05_RS13490 2547830..2549080 + 1251 WP_001012223.1 FemA/FemB family glycyltransferase FmhA -
AOZ05_RS13495 2549177..2549908 - 732 WP_000615461.1 amino acid ABC transporter ATP-binding protein -
AOZ05_RS13500 2549905..2550624 - 720 WP_000479576.1 amino acid ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-88)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-74)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10437.95 Da        Isoelectric Point: 9.9143

>T73552 WP_000113262.1 NZ_CP019945:c2546071-2545805 [Staphylococcus aureus]
MARLNITFSPQAFEDYKYFQQNDKKMVKKINELLKSIDRNGALEGIGKPEKLKSNLTGYYSRRINHEHRLVYTVDDNHIK
IASCKYHY

Download         Length: 267 bp

>T73552 NZ_CP019945:c2546071-2545805 [Staphylococcus aureus]
ATGGCTAGGTTAAATATTACGTTTTCGCCTCAAGCCTTTGAAGATTATAAGTATTTTCAGCAGAACGATAAAAAAATGGT
GAAGAAGATTAATGAGTTACTTAAAAGTATTGACAGAAATGGTGCATTGGAAGGTATAGGTAAGCCTGAAAAGTTAAAAT
CGAATCTGACTGGGTATTATAGTAGACGTATCAATCACGAACATAGATTGGTTTATACAGTAGATGACAATCATATAAAA
ATAGCATCATGTAAATACCATTATTAA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9433.60 Da        Isoelectric Point: 4.3407

>AT73552 WP_000584499.1 NZ_CP019945:c2546322-2546071 [Staphylococcus aureus]
MIIKNYSYARQNLKALMTKVNDDSDMVTVTSTDDKNVVIMSESDYNSMMETLYLQQNPNNAEHLAQSIADLERGKTITKD
IDV

Download         Length: 252 bp

>AT73552 NZ_CP019945:c2546322-2546071 [Staphylococcus aureus]
ATGATTATTAAAAATTATTCATACGCTCGACAGAATTTAAAGGCACTTATGACAAAAGTAAATGATGATAGTGATATGGT
AACTGTAACATCTACTGATGATAAAAACGTAGTAATCATGTCAGAATCAGATTATAACTCCATGATGGAAACACTTTACC
TCCAACAGAACCCAAATAATGCTGAACACTTAGCTCAATCAATTGCAGATCTAGAACGTGGGAAAACTATAACGAAAGAT
ATAGATGTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6L8G
PDB 6L8F
PDB 7CUA
PDB 6L8E

Antitoxin

Source ID Structure
PDB 6L8G
PDB 6L8F
PDB 7BWF
PDB 6L8E
AlphaFold DB T1YB60

References