Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/-
Location 2058608..2059022 Replicon chromosome
Accession NZ_CP019945
Organism Staphylococcus aureus strain BA01611

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag AOZ05_RS10730 Protein ID WP_031886311.1
Coordinates 2058771..2059022 (-) Length 84 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag AOZ05_RS15385 Protein ID WP_000028424.1
Coordinates 2058608..2058781 (-) Length 58 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AOZ05_RS10685 2053939..2054043 + 105 WP_078098968.1 hypothetical protein -
AOZ05_RS10695 2054145..2056591 - 2447 Protein_1981 virulence-associated E family protein -
AOZ05_RS10700 2056643..2056843 - 201 WP_031886313.1 DUF1514 family protein -
AOZ05_RS10705 2056911..2057063 - 153 WP_001667056.1 phage transcriptional activator RinB -
AOZ05_RS10710 2057063..2057449 - 387 WP_001555739.1 hypothetical protein -
AOZ05_RS10715 2057439..2057675 - 237 WP_000483477.1 hypothetical protein -
AOZ05_RS10720 2057700..2057936 - 237 WP_000195806.1 DUF1381 domain-containing protein -
AOZ05_RS10725 2057973..2058431 - 459 WP_054249680.1 dUTPase -
AOZ05_RS15380 2058446..2058607 - 162 WP_000889680.1 hypothetical protein -
AOZ05_RS15385 2058608..2058781 - 174 WP_000028424.1 hypothetical protein Antitoxin
AOZ05_RS10730 2058771..2059022 - 252 WP_031886311.1 DUF1024 family protein Toxin
AOZ05_RS10735 2059015..2059299 - 285 WP_031901038.1 hypothetical protein -
AOZ05_RS10740 2059296..2059733 - 438 WP_031796778.1 hypothetical protein -
AOZ05_RS10745 2059730..2059924 - 195 WP_031794818.1 hypothetical protein -
AOZ05_RS10750 2059921..2060328 - 408 WP_080607966.1 hypothetical protein -
AOZ05_RS10755 2060331..2060537 - 207 WP_000693993.1 hypothetical protein -
AOZ05_RS10760 2060552..2060800 - 249 WP_031902402.1 phi PVL orf 51-like protein -
AOZ05_RS10765 2060801..2061160 - 360 WP_080607967.1 hypothetical protein -
AOZ05_RS10770 2061172..2061429 - 258 WP_054249697.1 helix-turn-helix transcriptional regulator -
AOZ05_RS10775 2061430..2061615 - 186 WP_054249698.1 DUF3113 family protein -
AOZ05_RS10780 2061615..2062022 - 408 WP_054249699.1 RusA family crossover junction endodeoxyribonuclease -
AOZ05_RS10785 2062032..2062253 - 222 WP_001123688.1 DUF3269 family protein -
AOZ05_RS10790 2062256..2062471 - 216 WP_031902399.1 hypothetical protein -
AOZ05_RS10795 2062468..2063709 - 1242 WP_031902398.1 AAA family ATPase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 2025831..2072659 46828


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Protein of unknown function DUF1024

(1-82)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 84 a.a.        Molecular weight: 9405.28 Da        Isoelectric Point: 3.8567

>T73546 WP_031886311.1 NZ_CP019945:c2059022-2058771 [Staphylococcus aureus]
MNNREQIEQSVISASAYNGNDTEGLLKEIEDVYKKAQAFDEILEGMTNAIQHSVKEGVELDEAVGIMTGQVVYKYEEEQE
NEY

Download         Length: 252 bp

>T73546 NZ_CP019945:c2059022-2058771 [Staphylococcus aureus]
ATGAATAACCGCGAACAAATTGAACAGTCCGTTATAAGTGCTAGTGCGTATAACGGCAATGACACAGAGGGATTGCTAAA
AGAGATTGAGGACGTGTATAAGAAAGCACAAGCGTTTGATGAAATACTTGAGGGAATGACAAATGCTATACAACATTCAG
TTAAAGAAGGTGTTGAACTTGATGAAGCAGTAGGGATTATGACGGGGCAAGTGGTCTATAAATATGAGGAGGAGCAGGAA
AATGAGTATTAG

Antitoxin


Download         Length: 58 a.a.        Molecular weight: 6468.29 Da        Isoelectric Point: 4.2484

>AT73546 WP_000028424.1 NZ_CP019945:c2058781-2058608 [Staphylococcus aureus]
MSISVGDKVYNHETNESLEIVQLVGDIRDTHYKLSDDSVISIIDFITKPIYLIKGDE

Download         Length: 174 bp

>AT73546 NZ_CP019945:c2058781-2058608 [Staphylococcus aureus]
ATGAGTATTAGTGTAGGAGATAAAGTATATAACCATGAAACAAACGAAAGTCTAGAGATTGTGCAATTGGTCGGAGATAT
TAGAGATACACATTATAAACTGTCTGATGATTCAGTTATTAGCATTATAGATTTTATTACTAAACCAATTTATCTAATTA
AGGGGGACGAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References