Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | prlF-yhaV (relBE)/YhaV-PrlF |
Location | 638559..639358 | Replicon | chromosome |
Accession | NZ_CP019944 | ||
Organism | Escherichia coli strain DSM 103246 |
Toxin (Protein)
Gene name | yhaV | Uniprot ID | A0A246NUP1 |
Locus tag | Eco28_RS03280 | Protein ID | WP_021577991.1 |
Coordinates | 638559..639023 (-) | Length | 155 a.a. |
Antitoxin (Protein)
Gene name | prlF | Uniprot ID | S1EB98 |
Locus tag | Eco28_RS03285 | Protein ID | WP_001307405.1 |
Coordinates | 639023..639358 (-) | Length | 112 a.a. |
Genomic Context
Location: 637695..638504 (810 bp)
Type: Others
Protein ID: WP_000072187.1
Type: Others
Protein ID: WP_000072187.1
Location: 641453..642787 (1335 bp)
Type: Others
Protein ID: WP_000599636.1
Type: Others
Protein ID: WP_000599636.1
Location: 642803..643573 (771 bp)
Type: Others
Protein ID: WP_001058233.1
Type: Others
Protein ID: WP_001058233.1
Location: 633560..633994 (435 bp)
Type: Others
Protein ID: WP_000948826.1
Type: Others
Protein ID: WP_000948826.1
Location: 634012..634890 (879 bp)
Type: Others
Protein ID: WP_001295548.1
Type: Others
Protein ID: WP_001295548.1
Location: 634880..635659 (780 bp)
Type: Others
Protein ID: WP_000406214.1
Type: Others
Protein ID: WP_000406214.1
Location: 635670..636143 (474 bp)
Type: Others
Protein ID: WP_001295547.1
Type: Others
Protein ID: WP_001295547.1
Location: 636166..637446 (1281 bp)
Type: Others
Protein ID: WP_021577992.1
Type: Others
Protein ID: WP_021577992.1
Location: 638559..639023 (465 bp)
Type: Toxin
Protein ID: WP_021577991.1
Type: Toxin
Protein ID: WP_021577991.1
Location: 639023..639358 (336 bp)
Type: Antitoxin
Protein ID: WP_001307405.1
Type: Antitoxin
Protein ID: WP_001307405.1
Location: 639507..641078 (1572 bp)
Type: Others
Protein ID: WP_001273756.1
Type: Others
Protein ID: WP_001273756.1
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Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
Eco28_RS03245 | 633560..633994 | - | 435 | WP_000948826.1 | PTS sugar transporter subunit IIA | - |
Eco28_RS03250 | 634012..634890 | - | 879 | WP_001295548.1 | PTS system mannose/fructose/sorbose family transporter subunit IID | - |
Eco28_RS03255 | 634880..635659 | - | 780 | WP_000406214.1 | PTS mannose/fructose/sorbose/N-acetylgalactosamine transporter subunit IIC | - |
Eco28_RS03260 | 635670..636143 | - | 474 | WP_001295547.1 | PTS N-acetylgalactosamine transporter subunit IIB | - |
Eco28_RS03265 | 636166..637446 | - | 1281 | WP_021577992.1 | tagatose-bisphosphate aldolase subunit KbaZ | - |
Eco28_RS03275 | 637695..638504 | + | 810 | WP_000072187.1 | aga operon transcriptional regulator AgaR | - |
Eco28_RS03280 | 638559..639023 | - | 465 | WP_021577991.1 | type II toxin-antitoxin system ribonuclease toxin YhaV | Toxin |
Eco28_RS03285 | 639023..639358 | - | 336 | WP_001307405.1 | type II toxin-antitoxin system antitoxin PrlF | Antitoxin |
Eco28_RS03290 | 639507..641078 | - | 1572 | WP_001273756.1 | galactarate dehydratase | - |
Eco28_RS03295 | 641453..642787 | + | 1335 | WP_000599636.1 | galactarate/glucarate/glycerate transporter GarP | - |
Eco28_RS03300 | 642803..643573 | + | 771 | WP_001058233.1 | 2-dehydro-3-deoxyglucarate aldolase | - |
Associated MGEs
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MGE detail | Similar MGEs | Relative position | MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|---|---|---|---|---|---|---|
No matching records found |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 155 a.a. Molecular weight: 17836.25 Da Isoelectric Point: 9.6924
>T73512 WP_021577991.1 NZ_CP019944:c639023-638559 [Escherichia coli]
MDFPQRVNGWALYAHPCFQETYDALVAEVETLKGKDPENYQRKAATKILAVVHKVIEEHITVNPSSPAFRHGKSLGSGKN
KDWSRVKFGAGRYRLFFRYSEKEKVIILGWMNDENTLRTYGKKTDAYTVFSKMLKRGHPPADWETLTRETEETH
MDFPQRVNGWALYAHPCFQETYDALVAEVETLKGKDPENYQRKAATKILAVVHKVIEEHITVNPSSPAFRHGKSLGSGKN
KDWSRVKFGAGRYRLFFRYSEKEKVIILGWMNDENTLRTYGKKTDAYTVFSKMLKRGHPPADWETLTRETEETH
Download Length: 465 bp
>T73512 NZ_CP019944:c639023-638559 [Escherichia coli]
ATGGATTTTCCACAAAGGGTTAATGGTTGGGCGCTATATGCTCATCCCTGTTTTCAGGAAACCTACGACGCTTTAGTTGC
CGAAGTCGAGACATTAAAGGGAAAAGATCCTGAAAATTATCAGAGAAAAGCCGCCACAAAGATATTGGCGGTAGTCCATA
AAGTGATTGAGGAGCATATCACGGTCAATCCATCATCACCGGCATTCCGTCATGGCAAGTCGTTAGGCTCTGGGAAAAAT
AAAGACTGGTCACGGGTAAAATTTGGTGCTGGTCGTTATCGTCTCTTCTTTCGTTATAGTGAAAAAGAGAAAGTCATCAT
TCTGGGATGGATGAACGATGAAAACACGCTGCGCACCTACGGTAAAAAAACAGATGCCTATACCGTATTCAGCAAAATGT
TAAAAAGAGGACATCCTCCTGCCGACTGGGAAACCCTCACCCGAGAGACAGAAGAAACCCATTGA
ATGGATTTTCCACAAAGGGTTAATGGTTGGGCGCTATATGCTCATCCCTGTTTTCAGGAAACCTACGACGCTTTAGTTGC
CGAAGTCGAGACATTAAAGGGAAAAGATCCTGAAAATTATCAGAGAAAAGCCGCCACAAAGATATTGGCGGTAGTCCATA
AAGTGATTGAGGAGCATATCACGGTCAATCCATCATCACCGGCATTCCGTCATGGCAAGTCGTTAGGCTCTGGGAAAAAT
AAAGACTGGTCACGGGTAAAATTTGGTGCTGGTCGTTATCGTCTCTTCTTTCGTTATAGTGAAAAAGAGAAAGTCATCAT
TCTGGGATGGATGAACGATGAAAACACGCTGCGCACCTACGGTAAAAAAACAGATGCCTATACCGTATTCAGCAAAATGT
TAAAAAGAGGACATCCTCCTGCCGACTGGGAAACCCTCACCCGAGAGACAGAAGAAACCCATTGA
Antitoxin
Download Length: 112 a.a. Molecular weight: 12358.94 Da Isoelectric Point: 4.8616
>AT73512 WP_001307405.1 NZ_CP019944:c639358-639023 [Escherichia coli]
MPANARSHAVLTTESKVTIRGQTTIPAPVREALKLKPGQDSIHYEILPGGQVFMCRLGDEQEDHTMNAFLRFLDADIQNN
PQKTRPFNIQQGKKLVAGMDVNIDDEIGDDE
MPANARSHAVLTTESKVTIRGQTTIPAPVREALKLKPGQDSIHYEILPGGQVFMCRLGDEQEDHTMNAFLRFLDADIQNN
PQKTRPFNIQQGKKLVAGMDVNIDDEIGDDE
Download Length: 336 bp
>AT73512 NZ_CP019944:c639358-639023 [Escherichia coli]
ATGCCCGCTAATGCTCGCTCTCACGCTGTACTGACCACTGAATCAAAGGTCACGATACGCGGACAAACAACTATCCCCGC
GCCAGTGCGTGAGGCTTTAAAACTGAAGCCAGGCCAGGACAGCATTCATTACGAAATTCTGCCTGGTGGGCAAGTATTTA
TGTGCCGACTGGGAGATGAACAGGAGGATCATACTATGAATGCATTTTTGCGTTTTCTGGATGCAGATATCCAGAACAAC
CCGCAAAAAACTCGTCCATTCAACATTCAACAAGGAAAGAAACTTGTCGCTGGCATGGACGTCAACATTGATGATGAGAT
TGGCGACGACGAATAA
ATGCCCGCTAATGCTCGCTCTCACGCTGTACTGACCACTGAATCAAAGGTCACGATACGCGGACAAACAACTATCCCCGC
GCCAGTGCGTGAGGCTTTAAAACTGAAGCCAGGCCAGGACAGCATTCATTACGAAATTCTGCCTGGTGGGCAAGTATTTA
TGTGCCGACTGGGAGATGAACAGGAGGATCATACTATGAATGCATTTTTGCGTTTTCTGGATGCAGATATCCAGAACAAC
CCGCAAAAAACTCGTCCATTCAACATTCAACAAGGAAAGAAACTTGTCGCTGGCATGGACGTCAACATTGATGATGAGAT
TGGCGACGACGAATAA
Structures
Toxin
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Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A246NUP1 |
Antitoxin
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Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A0E0XVC7 |