Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) prlF-yhaV (relBE)/YhaV-PrlF
Location 638559..639358 Replicon chromosome
Accession NZ_CP019944
Organism Escherichia coli strain DSM 103246

Toxin (Protein)


Gene name yhaV Uniprot ID A0A246NUP1
Locus tag Eco28_RS03280 Protein ID WP_021577991.1
Coordinates 638559..639023 (-) Length 155 a.a.

Antitoxin (Protein)


Gene name prlF Uniprot ID S1EB98
Locus tag Eco28_RS03285 Protein ID WP_001307405.1
Coordinates 639023..639358 (-) Length 112 a.a.

Genomic Context


Eco28_RS03275Eco28_RS03295Eco28_RS03300Eco28_RS03245Eco28_RS03250Eco28_RS03255Eco28_RS03260Eco28_RS03265Eco28_RS03280Eco28_RS03285Eco28_RS03290
Location: 637695..638504 (810 bp)
Type: Others
Protein ID: WP_000072187.1
Location: 641453..642787 (1335 bp)
Type: Others
Protein ID: WP_000599636.1
Location: 642803..643573 (771 bp)
Type: Others
Protein ID: WP_001058233.1
Location: 633560..633994 (435 bp)
Type: Others
Protein ID: WP_000948826.1
Location: 634012..634890 (879 bp)
Type: Others
Protein ID: WP_001295548.1
Location: 634880..635659 (780 bp)
Type: Others
Protein ID: WP_000406214.1
Location: 635670..636143 (474 bp)
Type: Others
Protein ID: WP_001295547.1
Location: 636166..637446 (1281 bp)
Type: Others
Protein ID: WP_021577992.1
Location: 638559..639023 (465 bp)
Type: Toxin
Protein ID: WP_021577991.1
Location: 639023..639358 (336 bp)
Type: Antitoxin
Protein ID: WP_001307405.1
Location: 639507..641078 (1572 bp)
Type: Others
Protein ID: WP_001273756.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
Eco28_RS03245633560..633994-435WP_000948826.1PTS sugar transporter subunit IIA-
Eco28_RS03250634012..634890-879WP_001295548.1PTS system mannose/fructose/sorbose family transporter subunit IID-
Eco28_RS03255634880..635659-780WP_000406214.1PTS mannose/fructose/sorbose/N-acetylgalactosamine transporter subunit IIC-
Eco28_RS03260635670..636143-474WP_001295547.1PTS N-acetylgalactosamine transporter subunit IIB-
Eco28_RS03265636166..637446-1281WP_021577992.1tagatose-bisphosphate aldolase subunit KbaZ-
Eco28_RS03275637695..638504+810WP_000072187.1aga operon transcriptional regulator AgaR-
Eco28_RS03280638559..639023-465WP_021577991.1type II toxin-antitoxin system ribonuclease toxin YhaVToxin
Eco28_RS03285639023..639358-336WP_001307405.1type II toxin-antitoxin system antitoxin PrlFAntitoxin
Eco28_RS03290639507..641078-1572WP_001273756.1galactarate dehydratase-
Eco28_RS03295641453..642787+1335WP_000599636.1galactarate/glucarate/glycerate transporter GarP-
Eco28_RS03300642803..643573+771WP_001058233.12-dehydro-3-deoxyglucarate aldolase-

Associated MGEs


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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(12-150)

Antitoxin

(14-110)


Sequences


Toxin        


Download         Length: 155 a.a.        Molecular weight: 17836.25 Da        Isoelectric Point: 9.6924

>T73512 WP_021577991.1 NZ_CP019944:c639023-638559 [Escherichia coli]
MDFPQRVNGWALYAHPCFQETYDALVAEVETLKGKDPENYQRKAATKILAVVHKVIEEHITVNPSSPAFRHGKSLGSGKN
KDWSRVKFGAGRYRLFFRYSEKEKVIILGWMNDENTLRTYGKKTDAYTVFSKMLKRGHPPADWETLTRETEETH

Download         Length: 465 bp

>T73512 NZ_CP019944:c639023-638559 [Escherichia coli]
ATGGATTTTCCACAAAGGGTTAATGGTTGGGCGCTATATGCTCATCCCTGTTTTCAGGAAACCTACGACGCTTTAGTTGC
CGAAGTCGAGACATTAAAGGGAAAAGATCCTGAAAATTATCAGAGAAAAGCCGCCACAAAGATATTGGCGGTAGTCCATA
AAGTGATTGAGGAGCATATCACGGTCAATCCATCATCACCGGCATTCCGTCATGGCAAGTCGTTAGGCTCTGGGAAAAAT
AAAGACTGGTCACGGGTAAAATTTGGTGCTGGTCGTTATCGTCTCTTCTTTCGTTATAGTGAAAAAGAGAAAGTCATCAT
TCTGGGATGGATGAACGATGAAAACACGCTGCGCACCTACGGTAAAAAAACAGATGCCTATACCGTATTCAGCAAAATGT
TAAAAAGAGGACATCCTCCTGCCGACTGGGAAACCCTCACCCGAGAGACAGAAGAAACCCATTGA

Antitoxin


Download         Length: 112 a.a.        Molecular weight: 12358.94 Da        Isoelectric Point: 4.8616

>AT73512 WP_001307405.1 NZ_CP019944:c639358-639023 [Escherichia coli]
MPANARSHAVLTTESKVTIRGQTTIPAPVREALKLKPGQDSIHYEILPGGQVFMCRLGDEQEDHTMNAFLRFLDADIQNN
PQKTRPFNIQQGKKLVAGMDVNIDDEIGDDE

Download         Length: 336 bp

>AT73512 NZ_CP019944:c639358-639023 [Escherichia coli]
ATGCCCGCTAATGCTCGCTCTCACGCTGTACTGACCACTGAATCAAAGGTCACGATACGCGGACAAACAACTATCCCCGC
GCCAGTGCGTGAGGCTTTAAAACTGAAGCCAGGCCAGGACAGCATTCATTACGAAATTCTGCCTGGTGGGCAAGTATTTA
TGTGCCGACTGGGAGATGAACAGGAGGATCATACTATGAATGCATTTTTGCGTTTTCTGGATGCAGATATCCAGAACAAC
CCGCAAAAAACTCGTCCATTCAACATTCAACAAGGAAAGAAACTTGTCGCTGGCATGGACGTCAACATTGATGATGAGAT
TGGCGACGACGAATAA

Similar Proteins


Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures


Toxin

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Source
ID
Structure
AlphaFold DBA0A246NUP1


Antitoxin

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Source
ID
Structure
AlphaFold DBA0A0E0XVC7

References