Detailed information of TA system TA073490

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/HigB-HigA
• Location: 1833015..1833622
• Replicon: chromosome
• Accession: NZ_CP019913
• Organism: Desulfococcus multivorans strain DSM 2059

Toxin (Protein)

• Gene name: higB
• Uniprot ID: -
• Locus tag: B2D07_RS08010
• Protein ID: WP_078081377.1
• Coordinates: 1833341..1833622 (-)
• Length: 94 a.a.

Antitoxin (Protein)

• Gene name: graA
• Uniprot ID: -
• Locus tag: B2D07_RS08005
• Protein ID: WP_020875561.1
• Coordinates: 1833015..1833329 (-)
• Length: 105 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
B2D07_RS07970	1828781..1829233	+	453	WP_078081234.1	RidA family protein	-
B2D07_RS07975	1829243..1830088	+	846	WP_020875556.1	PhzF family phenazine biosynthesis protein	-
B2D07_RS07980	1830224..1830640	-	417	WP_020875557.1	type II toxin-antitoxin system HicB family antitoxin	-
B2D07_RS07985	1830650..1830838	-	189	WP_078081235.1	type II toxin-antitoxin system HicA family toxin	-
B2D07_RS07990	1830985..1832124	+	1140	WP_020875558.1	NADH:flavin oxidoreductase	-
B2D07_RS07995	1832244..1832486	+	243	WP_020875559.1	type II toxin-antitoxin system Phd/YefM family antitoxin	-
B2D07_RS08000	1832486..1832746	+	261	WP_020875560.1	Txe/YoeB family addiction module toxin	-
B2D07_RS08005	1833015..1833329	-	315	WP_020875561.1	HigA family addiction module antidote protein	Antitoxin
B2D07_RS08010	1833341..1833622	-	282	WP_078081377.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
B2D07_RS08015	1833983..1834468	+	486	WP_020875562.1	DUF1772 domain-containing protein	-
B2D07_RS08020	1834772..1835395	+	624	WP_040414325.1	hydrolase	-
B2D07_RS08025	1835418..1836035	+	618	WP_200809279.1	group 1 truncated hemoglobin	-
B2D07_RS08035	1836711..1837400	+	690	WP_040414326.1	aquaporin Z	-
B2D07_RS08040	1837453..1838535	+	1083	WP_020875566.1	endonuclease/exonuclease/phosphatase family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-1 (3-93)

Antitoxin

• Cro/C1-type helix-turn-helix domain (35-73)

Sequences

Toxin

Protein

• Length: 94 a.a.
• Molecular weight: 10986.58 Da
• Isoelectric Point: 10.0490

>T73490 WP_078081377.1 NZ_CP019913:c1833622-1833341 [Desulfococcus multivorans]
MIKTFADKETQQLFVSGKSKRLPSDLLRRAIRRLEFIHFANDIKDLLVPRSNRLHALKGDRKGQHSISINDQWRICFRFI
EGDAYDVEVTDYH

Nucleotide

• Length: 282 bp

>T73490 NZ_CP019913:c1833622-1833341 [Desulfococcus multivorans]
ATGATAAAAACATTTGCCGATAAAGAAACCCAGCAATTATTTGTTTCCGGCAAATCGAAACGCTTACCATCCGATTTATT
ACGAAGGGCAATAAGACGTTTAGAATTTATTCACTTTGCAAATGACATAAAAGACCTTTTGGTGCCACGCAGCAACAGGC
TCCATGCGCTTAAAGGCGACAGGAAAGGGCAACACTCAATATCGATAAATGACCAGTGGCGAATATGTTTCCGTTTCATT
GAAGGCGATGCCTACGATGTTGAGGTTACCGATTACCATTAA

Antitoxin

Protein

• Length: 105 a.a.
• Molecular weight: 12044.70 Da
• Isoelectric Point: 8.6052

>AT73490 WP_020875561.1 NZ_CP019913:c1833329-1833015 [Desulfococcus multivorans]
MAIPNTTKREIKPTHPGEMLREDFMPDYDLNTASMANALGVSRQTINEILRERRAISPAMALRLSRLFSNSPEFWLNAQH
SWDLWDSEKRYSKELSQIRPLNAA

Nucleotide

• Length: 315 bp

>AT73490 NZ_CP019913:c1833329-1833015 [Desulfococcus multivorans]
ATGGCTATACCCAATACGACAAAGCGTGAAATTAAGCCGACTCATCCCGGTGAAATGCTTAGAGAGGATTTCATGCCGGA
CTATGATCTGAACACGGCTTCCATGGCAAACGCATTAGGCGTGTCACGCCAAACAATTAATGAAATTTTGAGAGAACGAC
GTGCTATCAGTCCGGCTATGGCGCTAAGATTATCTCGACTTTTCAGCAATTCACCGGAATTCTGGCTGAATGCCCAGCAT
TCGTGGGACCTTTGGGATTCGGAAAAACGCTACAGTAAAGAATTGTCTCAAATCCGACCCTTGAATGCCGCATGA