Detailed information of TA system TA073443

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): hok-sok/-
• Location: 839060..839317
• Replicon: chromosome
• Accession: NZ_CP019903
• Organism: Escherichia coli strain MDR_56

Toxin (Protein)

• Gene name: hokA
• Uniprot ID: A0A0L6NKI3
• Locus tag: B1200_RS04425
• Protein ID: WP_001135743.1
• Coordinates: 839060..839212 (-)
• Length: 51 a.a.

Antitoxin (RNA)

Gene name	sokA
Locus tag	-
Coordinates	839263..839317 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
B1200_RS04400	835158..835817	+	660	WP_000747625.1	OmpA family lipoprotein	-
B1200_RS04405	835921..836895	+	975	WP_000805008.1	glyoxylate/hydroxypyruvate reductase GhrB	-
B1200_RS04410	836945..837655	-	711	WP_000190516.1	DUF3053 domain-containing protein	-
B1200_RS04415	838089..838379	+	291	WP_000455798.1	HTH-type transcriptional regulator	-
B1200_RS04420	838660..838872	+	213	WP_000014594.1	RNA chaperone/antiterminator CspA	-
B1200_RS04425	839060..839212	-	153	WP_001135743.1	type I toxin-antitoxin system toxin HokA	Toxin
-	839263..839317	+	55	-	-	Antitoxin
B1200_RS04430	839534..841603	-	2070	WP_001291790.1	glycine--tRNA ligase subunit beta	-
B1200_RS04435	841613..842524	-	912	WP_001168544.1	glycine--tRNA ligase subunit alpha	-
B1200_RS04440	842619..842927	-	309	WP_000980157.1	YsaB family lipoprotein	-
B1200_RS04445	843102..844097	+	996	WP_001182665.1	O-acetyltransferase WecH	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Hok/gef cell toxic protein (5-46)

Sequences

Toxin

Protein

• Length: 51 a.a.
• Molecular weight: 5898.11 Da
• Isoelectric Point: 7.7173

>T73443 WP_001135743.1 NZ_CP019903:c839212-839060 [Escherichia coli]
MPQKYRLLSLIVICFTLLFFTWMVRDSLCELHIKQGSYELAAFLACNLKE

Nucleotide

• Length: 153 bp

>T73443 NZ_CP019903:c839212-839060 [Escherichia coli]
ATGCCGCAGAAATATAGATTGCTTTCTTTAATAGTGATTTGTTTCACGCTTTTATTTTTTACCTGGATGGTAAGAGATTC
ACTGTGTGAATTGCATATTAAACAGGGAAGTTATGAGCTGGCGGCATTTTTAGCCTGCAATTTGAAAGAGTAA

Antitoxin

Nucleotide

• Length: 55 bp

>AT73443 NZ_CP019903:839263-839317 [Escherichia coli]
GTTCAGGCATAGGGTAGCCTCACTTTGATTTATAGTCAGGTGGGGCTTTTCTCTG

Structures

Toxin

• AlphaFold DB: A0A0L6NKI3

Antitoxin