Detailed information of TA system TA073441

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): ldrD-rdlD/Ldr(toxin)
• Location: 817275..817497
• Replicon: chromosome
• Accession: NZ_CP019903
• Organism: Escherichia coli strain MDR_56

Toxin (Protein)

• Gene name: ldrD
• Uniprot ID: S1NWX0
• Locus tag: B1200_RS29965
• Protein ID: WP_001295224.1
• Coordinates: 817275..817382 (-)
• Length: 36 a.a.

Antitoxin (RNA)

Gene name	rdlD
Locus tag	-
Coordinates	817431..817497 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
B1200_RS04265	812809..812997	-	189	WP_001063315.1	YhjR family protein	-
B1200_RS04270	813270..814841	+	1572	WP_001204944.1	cellulose biosynthesis protein BcsE	-
B1200_RS04275	814838..815029	+	192	WP_000988308.1	cellulose biosynthesis protein BcsF	-
B1200_RS04280	815026..816705	+	1680	WP_001562264.1	cellulose biosynthesis protein BcsG	-
B1200_RS04285	816792..816899	-	108	WP_001295224.1	type I toxin-antitoxin system toxin Ldr family protein	-
B1200_RS29965	817275..817382	-	108	WP_001295224.1	type I toxin-antitoxin system toxin Ldr family protein	Toxin
-	817431..817497	+	67	-	-	Antitoxin
B1200_RS04310	817858..819129	+	1272	WP_001318103.1	amino acid permease	-
B1200_RS04315	819159..820163	-	1005	WP_000107036.1	dipeptide ABC transporter ATP-binding subunit DppF	-
B1200_RS04320	820160..821143	-	984	WP_001196486.1	dipeptide ABC transporter ATP-binding protein	-
B1200_RS04325	821154..822056	-	903	WP_000084677.1	dipeptide ABC transporter permease DppC	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Type I toxin-antitoxin system, toxin Ldr (1-35)

Sequences

Toxin

Protein

• Length: 36 a.a.
• Molecular weight: 3882.70 Da
• Isoelectric Point: 9.0157

>T73441 WP_001295224.1 NZ_CP019903:c817382-817275 [Escherichia coli]
MTLAELGMAFWHDLAAPVIAGILASMIVNWLNKRK

Nucleotide

• Length: 108 bp

>T73441 NZ_CP019903:c817382-817275 [Escherichia coli]
ATGACGCTCGCAGAGCTGGGCATGGCCTTCTGGCATGATTTAGCGGCTCCGGTCATTGCTGGCATTCTTGCCAGCATGAT
CGTGAACTGGCTGAATAAGCGGAAGTAA

Antitoxin

Nucleotide

• Length: 67 bp

>AT73441 NZ_CP019903:817431-817497 [Escherichia coli]
GTCTAGATGCAAGAATGGCCCCCGTGGTGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTTCTC

Structures

Toxin

• AlphaFold DB: A0A4P7TSJ7

Antitoxin