Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 31736..32466 Replicon chromosome
Accession NZ_CP019889
Organism Enterobacter hormaechei strain FRM

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag B1023_RS00155 Protein ID WP_045348467.1
Coordinates 31736..32050 (+) Length 105 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag B1023_RS00160 Protein ID WP_127350921.1
Coordinates 32047..32466 (+) Length 140 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
B1023_RS00130 27403..28487 + 1085 Protein_25 cellulase family glycosylhydrolase -
B1023_RS00135 28393..29577 - 1185 WP_045348479.1 multidrug efflux MFS transporter EmrD -
B1023_RS00140 29753..30586 - 834 WP_045348468.1 DMT family transporter -
B1023_RS00145 30649..31095 - 447 WP_003861064.1 GNAT family N-acetyltransferase -
B1023_RS00150 31160..31249 - 90 WP_017383683.1 type I toxin-antitoxin system toxin TisB -
B1023_RS00155 31736..32050 + 315 WP_045348467.1 type II toxin-antitoxin system HigB family toxin Toxin
B1023_RS00160 32047..32466 + 420 WP_127350921.1 helix-turn-helix domain-containing protein Antitoxin
B1023_RS00165 32613..32711 + 99 WP_057979964.1 ilvB operon leader peptide IvbL -
B1023_RS00170 32818..34506 + 1689 WP_032672176.1 acetolactate synthase large subunit -
B1023_RS00175 34510..34797 + 288 WP_015570113.1 acetolactate synthase small subunit -
B1023_RS00180 34923..35516 + 594 WP_003861054.1 transcriptional regulator UhpA -
B1023_RS00185 35513..37018 + 1506 WP_017694010.1 signal transduction histidine-protein kinase/phosphatase UhpB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, mRNA interferase HigB

(21-93)

Antitoxin

Antitoxin HigA

(1-139)


Sequences

Toxin        


Download         Length: 105 a.a.        Molecular weight: 12408.52 Da        Isoelectric Point: 10.2825

>T73414 WP_045348467.1 NZ_CP019889:31736-32050 [Enterobacter hormaechei]
MHLISMKAILDAVSQFPQHREELLFLGRVIEKNHCPTPAALRKLFPTLDNFKYLDKHYVIDIANNNLRVVALIFLESQKF
YVRHVFTHKEYDRFTEKHRTKGKK

Download         Length: 315 bp

>T73414 NZ_CP019889:31736-32050 [Enterobacter hormaechei]
ATGCATTTAATCTCAATGAAGGCAATTTTGGATGCGGTAAGCCAGTTCCCGCAACACAGAGAAGAGCTTCTCTTTTTAGG
ACGAGTTATTGAAAAGAACCACTGCCCGACGCCCGCTGCACTGAGAAAACTTTTCCCAACGCTGGATAACTTCAAGTATC
TTGATAAGCATTATGTTATTGATATTGCAAATAACAATCTCAGAGTAGTGGCTCTCATCTTCTTGGAAAGCCAAAAGTTT
TATGTGCGCCATGTTTTTACTCATAAGGAATATGACCGTTTTACGGAGAAACATCGCACTAAGGGGAAGAAATGA

Antitoxin


Download         Length: 140 a.a.        Molecular weight: 15464.10 Da        Isoelectric Point: 5.6761

>AT73414 WP_127350921.1 NZ_CP019889:32047-32466 [Enterobacter hormaechei]
MMIVADAMKATHALVAAVPLLGEQPSEKDYKDALELVEYLLMNEPNSPLLDIVCARISHFEANRPEIVALRKEMESVPVG
IAVLRTLMDQYNLTISDFKDEIGSKSMVSRVLNGQRQLTLNHIKKLAARFGVSPALFIE

Download         Length: 420 bp

>AT73414 NZ_CP019889:32047-32466 [Enterobacter hormaechei]
ATGATGATCGTCGCTGATGCAATGAAAGCTACGCACGCCCTTGTTGCGGCCGTTCCTTTACTGGGTGAACAGCCGAGCGA
GAAAGATTATAAGGATGCGCTTGAGCTGGTTGAGTATCTCCTTATGAACGAGCCCAATAGCCCCTTGCTGGATATTGTGT
GCGCCAGAATTAGCCATTTCGAAGCTAATCGGCCAGAGATAGTCGCATTACGCAAGGAGATGGAGTCCGTTCCCGTTGGA
ATTGCAGTTTTAAGAACCTTGATGGATCAATACAATCTGACGATATCGGATTTTAAGGATGAAATTGGTAGTAAATCGAT
GGTTTCACGGGTTCTGAATGGTCAGAGACAGCTTACTCTGAACCATATCAAAAAGCTGGCGGCCAGATTTGGGGTATCAC
CTGCGTTATTTATTGAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References