Detailed information of TA system TA073391

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mqsRA (relBE)/MqsR-MqsA
• Location: 1663362..1664017
• Replicon: chromosome
• Accession: NZ_CP019869
• Organism: Bordetella pertussis strain J042

Toxin (Protein)

• Gene name: mqsR
• Uniprot ID: -
• Locus tag: BBB35_RS07960
• Protein ID: WP_047122780.1
• Coordinates: 1663362..1663613 (+)
• Length: 84 a.a.

Antitoxin (Protein)

• Gene name: mqsA
• Uniprot ID: Q7VY40
• Locus tag: BBB35_RS07965
• Protein ID: WP_003809516.1
• Coordinates: 1663616..1664017 (+)
• Length: 134 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
BBB35_RS07935	1658523..1659653	-	1131	WP_010930401.1	helix-turn-helix transcriptional regulator	-
BBB35_RS07940	1659888..1660469	+	582	WP_019247931.1	molybdenum cofactor biosysynthesis protein	-
BBB35_RS07945	1660606..1661670	+	1065	WP_003809510.1	fructose-bisphosphate aldolase class II	-
BBB35_RS07950	1661755..1662201	-	447	WP_003819827.1	GFA family protein	-
BBB35_RS07955	1662426..1663307	+	882	WP_003809513.1	phosphoribosylaminoimidazolesuccinocarboxamide synthase	-
BBB35_RS07960	1663362..1663613	+	252	WP_047122780.1	type II toxin-antitoxin system MqsR family toxin	Toxin
BBB35_RS07965	1663616..1664017	+	402	WP_003809516.1	type II toxin-antitoxin system MqsA family antitoxin	Antitoxin
BBB35_RS07970	1664037..1664273	+	237	WP_010930404.1	membrane protein	-
BBB35_RS07975	1664281..1664760	+	480	WP_010930405.1	disulfide bond formation protein B	-
BBB35_RS07980	1664910..1665425	+	516	WP_019247930.1	5-(carboxyamino)imidazole ribonucleotide mutase	-
BBB35_RS07985	1665428..1666618	+	1191	WP_010930406.1	5-(carboxyamino)imidazole ribonucleotide synthase	-
BBB35_RS07990	1666638..1667675	+	1038	WP_023853543.1	threonylcarbamoyl-AMP synthase	-
BBB35_RS07995	1667812..1668834	+	1023	WP_003809532.1	amino acid ABC transporter substrate-binding protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• mRNA interferase toxin MqsR (10-82)

Antitoxin

• Antitoxin MqsA/HigA-2 (1-131)

Sequences

Toxin

Protein

• Length: 84 a.a.
• Molecular weight: 8952.52 Da
• Isoelectric Point: 9.7242

>T73391 WP_047122780.1 NZ_CP019869:1663362-1663613 [Bordetella pertussis]
IGGAATKKPGQKRRAGAAALGLDFSAMVEIVLALTPRDFHKSMTTHADHRIWQDVYCPVTAMGAVYLKLTVLDGVPIVSF
KEL

Nucleotide

• Length: 252 bp

>T73391 NZ_CP019869:1663362-1663613 [Bordetella pertussis]
ATTGGAGGCGCGGCGACAAAAAAGCCGGGACAAAAGCGTCGCGCCGGGGCGGCGGCGCTGGGGCTGGATTTCAGCGCCAT
GGTCGAAATCGTGCTTGCATTGACACCGCGGGATTTCCACAAAAGCATGACTACCCATGCCGACCATCGCATTTGGCAGG
ACGTCTATTGCCCGGTGACAGCGATGGGCGCCGTCTACCTGAAGCTGACGGTCCTCGACGGCGTGCCGATCGTGTCGTTC
AAGGAGTTGTGA

Antitoxin

Protein

• Length: 134 a.a.
• Molecular weight: 14528.70 Da
• Isoelectric Point: 8.5005

>AT73391 WP_003809516.1 NZ_CP019869:1663616-1664017 [Bordetella pertussis]
MKCPVCGAAALARDTRDVPYSYKGETITIAAVTGDWCPACGENVLDGAESARVSEAMLAFNRLVNARRVDPGFIVRVRRK
LGLDQREAAALFGGGTNAFSRYENGKTRPPLALVKLLRLLDRHPELLEEVRAD

Nucleotide

• Length: 402 bp

>AT73391 NZ_CP019869:1663616-1664017 [Bordetella pertussis]
ATGAAGTGTCCCGTATGCGGAGCGGCCGCGCTGGCGCGTGATACTCGCGATGTGCCCTATAGCTACAAGGGCGAGACCAT
CACGATTGCGGCGGTGACGGGCGACTGGTGTCCGGCATGCGGCGAGAACGTGCTCGATGGCGCTGAATCGGCGCGGGTGA
GCGAGGCCATGCTGGCTTTCAACCGCCTGGTCAACGCCCGCCGCGTCGACCCCGGGTTCATCGTGCGGGTGCGCAGGAAG
CTGGGGCTGGACCAGCGCGAAGCCGCGGCGCTGTTCGGCGGCGGCACCAATGCGTTCTCGCGTTACGAGAACGGCAAGAC
GCGCCCGCCGCTGGCGCTGGTGAAGCTGCTCAGGCTGCTGGATCGCCATCCGGAGCTGCTGGAGGAAGTCCGTGCGGATT
GA

Structures

Antitoxin

• AlphaFold DB: A0A0H3LKS6