Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/VapI(antitoxin)
Location 67487..68915 Replicon chromosome
Accession NZ_CP019868
Organism Dehalococcoides mccartyi strain KBDCA2

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag B1778_RS00365 Protein ID WP_058316891.1
Coordinates 67487..67825 (+) Length 113 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag B1778_RS00370 Protein ID WP_058316890.1
Coordinates 67818..68915 (+) Length 366 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
B1778_RS00325 62824..63996 - 1173 WP_077997816.1 hypothetical protein -
B1778_RS00330 64265..64810 - 546 WP_077997817.1 AAA family ATPase -
B1778_RS00335 64814..65140 - 327 WP_077997818.1 hypothetical protein -
B1778_RS00340 65141..65719 - 579 WP_077997819.1 hypothetical protein -
B1778_RS00345 65712..65942 - 231 WP_077997820.1 hypothetical protein -
B1778_RS00350 65942..66238 - 297 WP_058316897.1 hypothetical protein -
B1778_RS00355 66238..66897 - 660 WP_077997821.1 hypothetical protein -
B1778_RS00360 66985..67365 + 381 WP_077997822.1 hypothetical protein -
B1778_RS00365 67487..67825 + 339 WP_058316891.1 hypothetical protein Toxin
B1778_RS00370 67818..68915 + 1098 WP_058316890.1 HigA family addiction module antidote protein Antitoxin
B1778_RS00375 69478..69786 - 309 WP_011308733.1 rubrerythrin -
B1778_RS00380 69975..71120 - 1146 WP_077997823.1 NTP transferase domain-containing protein -
B1778_RS00385 71121..71810 - 690 WP_011308735.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(16-89)


Sequences

Toxin        


Download         Length: 113 a.a.        Molecular weight: 12816.04 Da        Isoelectric Point: 8.8488

>T73390 WP_058316891.1 NZ_CP019868:67487-67825 [Dehalococcoides mccartyi]
MDIIFCNRKLASIFNSEKNLKIAYGPENCKKIMNRMAVLKAAYCLDEIPVKPPERRHELKGDRKGQLAVDLKHPCRLIFR
PTSNPLPLKTDGGLDLRSVKGIEILEVEDYHE

Download         Length: 339 bp

>T73390 NZ_CP019868:67487-67825 [Dehalococcoides mccartyi]
ATGGATATTATCTTTTGCAATAGGAAACTCGCAAGTATATTCAATAGTGAGAAAAATCTGAAGATAGCGTATGGCCCTGA
AAATTGCAAGAAGATTATGAATAGAATGGCTGTATTAAAAGCGGCCTACTGTCTTGATGAGATACCTGTAAAACCCCCTG
AGCGTAGACATGAGCTTAAAGGTGACAGGAAAGGACAATTAGCAGTTGACCTCAAACATCCCTGTCGGCTTATATTCCGA
CCCACTAGTAATCCTCTGCCCCTAAAGACTGATGGGGGCTTAGATCTTAGGAGTGTAAAAGGAATAGAAATTTTAGAAGT
TGAGGATTATCATGAGTAA

Antitoxin


Download         Length: 366 a.a.        Molecular weight: 41295.39 Da        Isoelectric Point: 6.3981

>AT73390 WP_058316890.1 NZ_CP019868:67818-68915 [Dehalococcoides mccartyi]
MSNTKLYRYEPDYVAVPGEILEENLEAQNIKKVDLASRCGLSTKTISQIINGTASISPETALGFQKVLGVSANIWLNLEA
DYRLFLAQQDLYKRLSKSGAWLNKFPIKELINKGFIEAKESIAEKTDQLLVFFGVSDIESWELSYNKLEVAFRHSPSFKS
LPEAIATWLRIGEICAAKVKCKPFDKSQFSEALNAIRILTPEEPKIFEPRLKEMCAEAGVALVFLEELPGMHLSGATRWI
TKDKALIMLSLRHKSDDHFWFSFFHEAGHILSGGKKSIFLDESNSWEDPEEDQANNFASDLLIPKQEYESFLKDGKFTSS
SVTCFAQNLGIAPGIVVGRLQHEQVIGWNSLYRLKRRFRLVEVCS

Download         Length: 1098 bp

>AT73390 NZ_CP019868:67818-68915 [Dehalococcoides mccartyi]
ATGAGTAATACAAAATTATATAGATATGAACCTGATTATGTTGCAGTTCCGGGCGAGATATTAGAAGAAAACCTTGAGGC
TCAAAATATCAAAAAAGTTGATTTGGCTTCAAGATGTGGTTTAAGCACTAAAACTATTAGTCAAATCATAAATGGTACTG
CATCAATTTCTCCGGAAACAGCCTTGGGTTTTCAAAAAGTACTTGGTGTTTCCGCCAATATTTGGCTTAATCTTGAGGCA
GATTATAGATTATTCCTGGCGCAACAAGATCTGTATAAGAGACTATCTAAGTCTGGTGCATGGCTTAACAAGTTTCCTAT
TAAAGAACTCATTAATAAAGGGTTTATAGAAGCTAAAGAAAGTATTGCTGAAAAAACAGACCAATTGCTTGTATTTTTCG
GAGTAAGCGACATAGAATCTTGGGAATTAAGCTATAACAAGTTGGAAGTTGCATTTAGGCATTCTCCTTCATTTAAAAGT
TTGCCAGAAGCTATTGCTACATGGTTAAGAATTGGAGAAATCTGCGCTGCAAAAGTGAAATGTAAACCCTTTGATAAATC
TCAATTTTCAGAGGCACTCAACGCTATACGCATCCTTACTCCTGAAGAACCAAAGATTTTTGAGCCCCGCTTGAAAGAAA
TGTGTGCAGAAGCCGGTGTTGCCTTGGTATTTCTAGAGGAATTACCTGGTATGCATTTGAGTGGTGCAACGCGATGGATA
ACGAAAGATAAAGCATTAATAATGCTTAGTCTTAGACATAAAAGTGATGACCATTTCTGGTTTAGTTTTTTTCATGAAGC
TGGTCATATATTATCTGGTGGCAAGAAGAGTATATTCCTCGATGAATCAAATTCATGGGAAGATCCCGAAGAAGATCAAG
CAAACAATTTTGCTTCCGATCTATTGATACCCAAACAGGAATATGAGTCTTTTTTAAAAGACGGTAAGTTCACATCATCT
TCTGTCACATGCTTTGCACAAAATTTGGGAATTGCGCCCGGAATAGTTGTAGGACGTTTACAACACGAACAAGTTATTGG
ATGGAATTCTTTGTATCGCTTAAAAAGGAGATTTAGATTGGTTGAGGTTTGTAGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References