Detailed information of TA system TA073312

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/COG4683-HTH_37
• Location: 611731..612384
• Replicon: chromosome
• Accession: NZ_CP019791
• Organism: Anaerohalosphaera lusitana strain ST-NAGAB-D1

Toxin (Protein)

• Gene name: higB
• Uniprot ID: -
• Locus tag: STSP2_RS02650
• Protein ID: WP_146659613.1
• Coordinates: 612034..612384 (-)
• Length: 117 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: -
• Locus tag: STSP2_RS02645
• Protein ID: WP_146659611.1
• Coordinates: 611731..612030 (-)
• Length: 100 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
STSP2_RS02635	608453..608995	-	543	WP_146659607.1	GNAT family N-acetyltransferase	-
STSP2_RS02640	609261..611714	+	2454	WP_169852926.1	PASTA domain-containing protein	-
STSP2_RS02645	611731..612030	-	300	WP_146659611.1	helix-turn-helix transcriptional regulator	Antitoxin
STSP2_RS02650	612034..612384	-	351	WP_146659613.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
STSP2_RS02655	612459..613007	-	549	WP_146659615.1	GNAT family N-acetyltransferase	-
STSP2_RS02660	613000..613455	-	456	WP_146659617.1	hypothetical protein	-
STSP2_RS02665	613458..614432	-	975	WP_146659619.1	ADP-glyceromanno-heptose 6-epimerase	-
STSP2_RS02670	614895..615281	-	387	WP_146659621.1	response regulator	-
STSP2_RS02675	615549..616670	-	1122	WP_146659623.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-like (12-105)

Antitoxin

• HigA2-like, helix-turn-helix domain (17-86)

Sequences

Toxin

Protein

• Length: 117 a.a.
• Molecular weight: 13782.76 Da
• Isoelectric Point: 10.1420

>T73312 WP_146659613.1 NZ_CP019791:c612384-612034 [Anaerohalosphaera lusitana]
MWEVEFTDEFEKWWQTLDVKQQEDVLVSVELLRNLGPHLARPYADTVKGSKHKNMKELRTQSKGRPLRTFYAFDPRRYAV
LLLGGDKKGNSRFYQQLINKADQIYDRHLNDIKKKG

Nucleotide

• Length: 351 bp

>T73312 NZ_CP019791:c612384-612034 [Anaerohalosphaera lusitana]
ATGTGGGAAGTGGAGTTCACAGACGAATTTGAGAAATGGTGGCAAACTCTGGACGTCAAGCAACAGGAAGATGTTCTGGT
CAGTGTCGAGTTGCTCAGGAATCTTGGTCCGCATCTTGCCCGGCCTTATGCCGACACAGTCAAGGGTTCCAAACACAAGA
ATATGAAGGAACTAAGAACTCAAAGCAAGGGCAGACCTCTGCGTACTTTTTATGCTTTCGATCCGAGACGATACGCAGTA
CTGCTGCTGGGCGGCGACAAAAAGGGAAACAGTAGATTTTACCAGCAACTTATCAACAAGGCTGACCAAATTTATGATCG
GCACTTGAATGATATAAAGAAAAAGGGGTGA

Antitoxin

Protein

• Length: 100 a.a.
• Molecular weight: 11266.19 Da
• Isoelectric Point: 10.4169

>AT73312 WP_146659611.1 NZ_CP019791:c612030-611731 [Anaerohalosphaera lusitana]
VARKFSELEKRMDPESVKRAKARAREEMAQMLLAEIRKETGITQENLAKSMGIKQPSLSKLESQRDMQISTLRRLIEALG
GKLELIAHMPEGDIKISQF

Nucleotide

• Length: 300 bp

>AT73312 NZ_CP019791:c612030-611731 [Anaerohalosphaera lusitana]
GTGGCACGTAAATTTTCAGAACTCGAAAAACGTATGGATCCTGAAAGCGTCAAACGAGCTAAGGCCCGAGCCAGGGAAGA
AATGGCTCAGATGCTCTTGGCCGAGATCCGAAAAGAAACAGGCATCACGCAGGAAAATCTCGCCAAAAGCATGGGAATCA
AACAGCCAAGCCTTTCCAAGTTGGAGTCACAGCGTGACATGCAGATAAGCACGCTGCGAAGGCTAATCGAGGCTCTGGGC
GGCAAACTCGAACTGATCGCCCACATGCCCGAGGGCGACATAAAGATAAGTCAATTTTGA