Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | DinJ-YafQ (relBE)/YafQ-RelB |
| Location | 17990..18534 | Replicon | plasmid pVbh_BscR1 |
| Accession | NZ_CP019790 | ||
| Organism | Bartonella schoenbuchensis R1 | ||
Toxin (Protein)
| Gene name | yafQ | Uniprot ID | N6UCY1 |
| Locus tag | BscR1v2_RS07640 | Protein ID | WP_010703142.1 |
| Coordinates | 17990..18259 (-) | Length | 90 a.a. |
Antitoxin (Protein)
| Gene name | dinJ | Uniprot ID | N6V9H6 |
| Locus tag | BscR1v2_RS07645 | Protein ID | WP_010703143.1 |
| Coordinates | 18262..18534 (-) | Length | 91 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| BscR1v2_RS08140 (BscR1v2_016300) | 13261..13782 | - | 522 | WP_194284960.1 | hypothetical protein | - |
| BscR1v2_RS07610 (BscR1v2_016310) | 13811..14116 | - | 306 | WP_010703167.1 | hypothetical protein | - |
| BscR1v2_RS07615 (BscR1v2_016320) | 14246..15517 | - | 1272 | WP_078690361.1 | replication protein C | - |
| BscR1v2_RS07620 (BscR1v2_016330) | 15997..16296 | + | 300 | WP_010703138.1 | hypothetical protein | - |
| BscR1v2_RS07625 (BscR1v2_016340) | 16293..16565 | + | 273 | WP_078690362.1 | type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family | - |
| BscR1v2_RS07630 (BscR1v2_016360) | 16959..17425 | - | 467 | Protein_23 | hypothetical protein | - |
| BscR1v2_RS07635 (BscR1v2_016370) | 17507..17812 | - | 306 | WP_010703141.1 | hypothetical protein | - |
| BscR1v2_RS07640 (BscR1v2_016380) | 17990..18259 | - | 270 | WP_010703142.1 | type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family | Toxin |
| BscR1v2_RS07645 (BscR1v2_016390) | 18262..18534 | - | 273 | WP_010703143.1 | type II toxin-antitoxin system RelB/DinJ family antitoxin | Antitoxin |
| BscR1v2_RS07650 (BscR1v2_016400) | 18782..19291 | - | 510 | WP_078690359.1 | hypothetical protein | - |
| BscR1v2_RS07660 (BscR1v2_016410) | 20173..20493 | + | 321 | WP_034989847.1 | helix-turn-helix domain-containing protein | - |
| BscR1v2_RS08145 (BscR1v2_016420) | 20609..21133 | - | 525 | WP_010703147.1 | hypothetical protein | - |
| BscR1v2_RS07670 (BscR1v2_016430) | 21159..21464 | - | 306 | WP_010703148.1 | hypothetical protein | - |
| BscR1v2_RS07675 | 21657..21878 | - | 222 | Protein_31 | hypothetical protein | - |
| BscR1v2_RS07680 | 21875..22183 | - | 309 | WP_034989869.1 | HigA family addiction module antidote protein | - |
| BscR1v2_RS07690 | 22262..22420 | - | 159 | Protein_33 | type II toxin-antitoxin system HicB family antitoxin | - |
| BscR1v2_RS07695 (BscR1v2_016460) | 22417..22701 | - | 285 | WP_010703150.1 | putative addiction module antidote protein | - |
| BscR1v2_RS07700 (BscR1v2_016470) | 22682..22990 | - | 309 | WP_034989871.1 | type II toxin-antitoxin system RelE/ParE family toxin | - |
| BscR1v2_RS07705 (BscR1v2_016480) | 23183..23383 | + | 201 | WP_010703152.1 | type II toxin-antitoxin system HicA family toxin | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Non-Mobilizable plasmid | - | virB4 / virB11 | 1..55761 | 55761 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 90 a.a. Molecular weight: 10562.23 Da Isoelectric Point: 10.6215
>T73307 WP_010703142.1 NZ_CP019790:c18259-17990 [Bartonella schoenbuchensis R1]
VRSVSYSGKFKKDMKRAKKRGKDMQKLTTIMHLLINKQQLPPSLNDHALQGNWKPRRDLHIEPDWLLIYIVNDEHVHFDR
TGTHSDLFK
VRSVSYSGKFKKDMKRAKKRGKDMQKLTTIMHLLINKQQLPPSLNDHALQGNWKPRRDLHIEPDWLLIYIVNDEHVHFDR
TGTHSDLFK
Download Length: 270 bp
>T73307 NZ_CP019790:c18259-17990 [Bartonella schoenbuchensis R1]
GTGCGTTCAGTAAGTTACTCTGGAAAGTTTAAAAAGGATATGAAACGCGCTAAAAAACGCGGAAAGGATATGCAAAAACT
TACAACGATTATGCATCTTTTAATCAATAAGCAGCAATTACCTCCCTCATTAAATGATCATGCATTACAAGGTAATTGGA
AACCACGTCGCGATCTTCATATAGAACCAGATTGGTTACTAATTTATATTGTTAATGATGAACATGTTCATTTTGACAGA
ACAGGAACCCATTCAGATTTATTTAAATAA
GTGCGTTCAGTAAGTTACTCTGGAAAGTTTAAAAAGGATATGAAACGCGCTAAAAAACGCGGAAAGGATATGCAAAAACT
TACAACGATTATGCATCTTTTAATCAATAAGCAGCAATTACCTCCCTCATTAAATGATCATGCATTACAAGGTAATTGGA
AACCACGTCGCGATCTTCATATAGAACCAGATTGGTTACTAATTTATATTGTTAATGATGAACATGTTCATTTTGACAGA
ACAGGAACCCATTCAGATTTATTTAAATAA
Antitoxin
Download Length: 91 a.a. Molecular weight: 10077.60 Da Isoelectric Point: 5.8486
>AT73307 WP_010703143.1 NZ_CP019790:c18534-18262 [Bartonella schoenbuchensis R1]
MDVATSSKDVIRARIDKSLKKEASAILANMGLTISDYVRIALTKVVNERGLPFDMHIPNAETLKTFEKTDKGEDVFYAKD
ATDLFKQLDI
MDVATSSKDVIRARIDKSLKKEASAILANMGLTISDYVRIALTKVVNERGLPFDMHIPNAETLKTFEKTDKGEDVFYAKD
ATDLFKQLDI
Download Length: 273 bp
>AT73307 NZ_CP019790:c18534-18262 [Bartonella schoenbuchensis R1]
ATGGATGTAGCAACAAGTTCGAAAGATGTTATACGCGCCCGAATAGACAAAAGTTTAAAAAAAGAAGCCAGTGCAATATT
AGCAAATATGGGGCTTACTATTTCTGATTATGTACGAATTGCTTTAACTAAAGTTGTCAATGAACGGGGATTGCCGTTCG
ATATGCATATACCTAATGCAGAAACACTTAAAACTTTTGAGAAAACTGATAAGGGGGAGGATGTTTTTTACGCGAAAGAT
GCAACGGATCTATTTAAGCAACTGGATATTTAA
ATGGATGTAGCAACAAGTTCGAAAGATGTTATACGCGCCCGAATAGACAAAAGTTTAAAAAAAGAAGCCAGTGCAATATT
AGCAAATATGGGGCTTACTATTTCTGATTATGTACGAATTGCTTTAACTAAAGTTGTCAATGAACGGGGATTGCCGTTCG
ATATGCATATACCTAATGCAGAAACACTTAAAACTTTTGAGAAAACTGATAAGGGGGAGGATGTTTTTTACGCGAAAGAT
GCAACGGATCTATTTAAGCAACTGGATATTTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|