Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | DinJ-YafQ (relBE)/YafQ-RelB |
| Location | 10642..11186 | Replicon | plasmid pVbh_BscR1 |
| Accession | NZ_CP019790 | ||
| Organism | Bartonella schoenbuchensis R1 | ||
Toxin (Protein)
| Gene name | yafQ | Uniprot ID | N6UCY1 |
| Locus tag | BscR1v2_RS07580 | Protein ID | WP_010703142.1 |
| Coordinates | 10642..10911 (-) | Length | 90 a.a. |
Antitoxin (Protein)
| Gene name | dinJ | Uniprot ID | N6V9H6 |
| Locus tag | BscR1v2_RS07585 | Protein ID | WP_010703143.1 |
| Coordinates | 10914..11186 (-) | Length | 91 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| BscR1v2_RS07540 (BscR1v2_016170) | 5720..6403 | + | 684 | WP_078690353.1 | ParA family protein | - |
| BscR1v2_RS07545 (BscR1v2_016180) | 6400..6768 | + | 369 | WP_078664118.1 | hypothetical protein | - |
| BscR1v2_RS07550 (BscR1v2_016190) | 6769..7092 | - | 324 | WP_078690354.1 | helix-turn-helix domain-containing protein | - |
| BscR1v2_RS07555 (BscR1v2_016200) | 7917..8168 | + | 252 | WP_078690355.1 | DNA-binding protein | - |
| BscR1v2_RS07560 (BscR1v2_016210) | 8165..8563 | + | 399 | WP_078690356.1 | type II toxin-antitoxin system VapC family toxin | - |
| BscR1v2_RS07565 (BscR1v2_016220) | 8572..9228 | - | 657 | WP_078690357.1 | recombinase family protein | - |
| BscR1v2_RS07570 (BscR1v2_016240) | 9610..9945 | - | 336 | WP_078690391.1 | hypothetical protein | - |
| BscR1v2_RS07575 (BscR1v2_016250) | 10160..10465 | - | 306 | WP_078690358.1 | hypothetical protein | - |
| BscR1v2_RS07580 (BscR1v2_016260) | 10642..10911 | - | 270 | WP_010703142.1 | type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family | Toxin |
| BscR1v2_RS07585 (BscR1v2_016270) | 10914..11186 | - | 273 | WP_010703143.1 | type II toxin-antitoxin system RelB/DinJ family antitoxin | Antitoxin |
| BscR1v2_RS07590 (BscR1v2_016280) | 11434..11943 | - | 510 | WP_078690359.1 | hypothetical protein | - |
| BscR1v2_RS07600 (BscR1v2_016290) | 12825..13145 | + | 321 | WP_034989847.1 | helix-turn-helix domain-containing protein | - |
| BscR1v2_RS08140 (BscR1v2_016300) | 13261..13782 | - | 522 | WP_194284960.1 | hypothetical protein | - |
| BscR1v2_RS07610 (BscR1v2_016310) | 13811..14116 | - | 306 | WP_010703167.1 | hypothetical protein | - |
| BscR1v2_RS07615 (BscR1v2_016320) | 14246..15517 | - | 1272 | WP_078690361.1 | replication protein C | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Non-Mobilizable plasmid | - | virB4 / virB11 | 1..55761 | 55761 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 90 a.a. Molecular weight: 10562.23 Da Isoelectric Point: 10.6215
>T73306 WP_010703142.1 NZ_CP019790:c10911-10642 [Bartonella schoenbuchensis R1]
VRSVSYSGKFKKDMKRAKKRGKDMQKLTTIMHLLINKQQLPPSLNDHALQGNWKPRRDLHIEPDWLLIYIVNDEHVHFDR
TGTHSDLFK
VRSVSYSGKFKKDMKRAKKRGKDMQKLTTIMHLLINKQQLPPSLNDHALQGNWKPRRDLHIEPDWLLIYIVNDEHVHFDR
TGTHSDLFK
Download Length: 270 bp
>T73306 NZ_CP019790:c10911-10642 [Bartonella schoenbuchensis R1]
GTGCGTTCAGTAAGTTACTCTGGAAAGTTTAAAAAGGATATGAAACGCGCTAAAAAACGCGGAAAGGATATGCAAAAACT
TACAACGATTATGCATCTTTTAATCAATAAGCAGCAATTACCTCCCTCATTAAATGATCATGCATTACAAGGTAATTGGA
AACCACGTCGCGATCTTCATATAGAACCAGATTGGTTACTAATTTATATTGTTAATGATGAACATGTTCATTTTGACAGA
ACAGGAACCCATTCAGATTTATTTAAATAA
GTGCGTTCAGTAAGTTACTCTGGAAAGTTTAAAAAGGATATGAAACGCGCTAAAAAACGCGGAAAGGATATGCAAAAACT
TACAACGATTATGCATCTTTTAATCAATAAGCAGCAATTACCTCCCTCATTAAATGATCATGCATTACAAGGTAATTGGA
AACCACGTCGCGATCTTCATATAGAACCAGATTGGTTACTAATTTATATTGTTAATGATGAACATGTTCATTTTGACAGA
ACAGGAACCCATTCAGATTTATTTAAATAA
Antitoxin
Download Length: 91 a.a. Molecular weight: 10077.60 Da Isoelectric Point: 5.8486
>AT73306 WP_010703143.1 NZ_CP019790:c11186-10914 [Bartonella schoenbuchensis R1]
MDVATSSKDVIRARIDKSLKKEASAILANMGLTISDYVRIALTKVVNERGLPFDMHIPNAETLKTFEKTDKGEDVFYAKD
ATDLFKQLDI
MDVATSSKDVIRARIDKSLKKEASAILANMGLTISDYVRIALTKVVNERGLPFDMHIPNAETLKTFEKTDKGEDVFYAKD
ATDLFKQLDI
Download Length: 273 bp
>AT73306 NZ_CP019790:c11186-10914 [Bartonella schoenbuchensis R1]
ATGGATGTAGCAACAAGTTCGAAAGATGTTATACGCGCCCGAATAGACAAAAGTTTAAAAAAAGAAGCCAGTGCAATATT
AGCAAATATGGGGCTTACTATTTCTGATTATGTACGAATTGCTTTAACTAAAGTTGTCAATGAACGGGGATTGCCGTTCG
ATATGCATATACCTAATGCAGAAACACTTAAAACTTTTGAGAAAACTGATAAGGGGGAGGATGTTTTTTACGCGAAAGAT
GCAACGGATCTATTTAAGCAACTGGATATTTAA
ATGGATGTAGCAACAAGTTCGAAAGATGTTATACGCGCCCGAATAGACAAAAGTTTAAAAAAAGAAGCCAGTGCAATATT
AGCAAATATGGGGCTTACTATTTCTGATTATGTACGAATTGCTTTAACTAAAGTTGTCAATGAACGGGGATTGCCGTTCG
ATATGCATATACCTAATGCAGAAACACTTAAAACTTTTGAGAAAACTGATAAGGGGGAGGATGTTTTTTACGCGAAAGAT
GCAACGGATCTATTTAAGCAACTGGATATTTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|