Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 1201134..1201761 Replicon chromosome
Accession NZ_CP019781
Organism Bartonella sp. WD16.2

Toxin (Protein)


Gene name graT Uniprot ID -
Locus tag BWD162_RS05115 Protein ID WP_078705707.1
Coordinates 1201447..1201761 (-) Length 105 a.a.

Antitoxin (Protein)


Gene name graA Uniprot ID -
Locus tag BWD162_RS05110 Protein ID WP_010704172.1
Coordinates 1201134..1201430 (-) Length 99 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BWD162_RS05065 1196142..1196450 - 309 WP_078705702.1 type II toxin-antitoxin system RelE/ParE family toxin -
BWD162_RS05075 1196872..1197302 + 431 Protein_961 single-stranded DNA-binding protein -
BWD162_RS05080 1197335..1197871 + 537 WP_078705704.1 hypothetical protein -
BWD162_RS05085 1197977..1198204 + 228 WP_010703919.1 ribbon-helix-helix protein, CopG family -
BWD162_RS05090 1198188..1198457 + 270 WP_078663354.1 type II toxin-antitoxin system RelE/ParE family toxin -
BWD162_RS05095 1198764..1199264 + 501 WP_078705705.1 hypothetical protein -
BWD162_RS05100 1199268..1200291 + 1024 Protein_966 N-6 DNA methylase -
BWD162_RS05105 1200305..1200892 + 588 WP_078705706.1 hypothetical protein -
BWD162_RS05110 1201134..1201430 - 297 WP_010704172.1 HigA family addiction module antidote protein Antitoxin
BWD162_RS05115 1201447..1201761 - 315 WP_078705707.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
BWD162_RS05120 1201822..1202113 + 292 Protein_970 hypothetical protein -
BWD162_RS05125 1202088..1205342 - 3255 WP_078705708.1 right-handed parallel beta-helix repeat-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(15-104)

Antitoxin

Cro/C1-type helix-turn-helix domain

(16-67)


Sequences

Toxin        


Download         Length: 105 a.a.        Molecular weight: 12318.52 Da        Isoelectric Point: 10.2544

>T73301 WP_078705707.1 NZ_CP019781:c1201761-1201447 [Bartonella sp. WD16.2]
MIRKLMNESDLMIETFADKRCKDLMEGKLPKGFPVALMRIVQRKLFMLDKAVNLKDLRSPPGNRLEALKGNRRGQYSIRI
NDQFRICFEWHFNGAYKVEIVDYH

Download         Length: 315 bp

>T73301 NZ_CP019781:c1201761-1201447 [Bartonella sp. WD16.2]
ATGATACGTAAATTAATGAATGAAAGTGACCTGATGATTGAAACCTTTGCAGATAAGCGATGTAAAGACCTTATGGAAGG
TAAGCTACCGAAAGGTTTTCCAGTGGCTTTGATGCGTATAGTTCAAAGAAAATTATTTATGCTCGATAAAGCAGTTAATC
TTAAAGATCTACGTAGCCCTCCGGGAAATCGCTTAGAAGCATTGAAAGGTAATCGCCGTGGTCAATATTCTATCCGTATC
AACGACCAATTTCGTATTTGTTTTGAGTGGCATTTTAACGGTGCTTATAAAGTTGAAATTGTAGATTATCATTGA

Antitoxin


Download         Length: 99 a.a.        Molecular weight: 11320.00 Da        Isoelectric Point: 5.1425

>AT73301 WP_010704172.1 NZ_CP019781:c1201430-1201134 [Bartonella sp. WD16.2]
MKNYIAIHPGEILREEYLKEYALSAYALAKALNVPRTRIERIVAENSPITPDTALRLAYFFDTTAEFWLNMQAAYDVNVL
QTEKADEFAKIDKFKQMA

Download         Length: 297 bp

>AT73301 NZ_CP019781:c1201430-1201134 [Bartonella sp. WD16.2]
ATGAAAAATTACATAGCGATCCATCCCGGAGAAATTCTACGGGAAGAATATTTAAAAGAATATGCCCTTTCTGCTTATGC
TCTTGCTAAAGCATTGAATGTTCCACGTACCCGGATAGAGCGTATTGTTGCTGAAAATAGCCCTATAACTCCTGATACAG
CGCTAAGATTGGCCTATTTTTTTGATACCACAGCTGAGTTCTGGCTTAACATGCAAGCTGCTTACGATGTTAATGTACTA
CAAACTGAAAAAGCTGACGAATTTGCTAAAATAGATAAATTTAAACAAATGGCTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References