Detailed information of TA system TA073297

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/HigB-HigA
• Location: 121605..122203
• Replicon: chromosome
• Accession: NZ_CP019781
• Organism: Bartonella sp. WD16.2

Toxin (Protein)

• Gene name: higB
• Uniprot ID: N6UCW6
• Locus tag: BWD162_RS00460
• Protein ID: WP_010703127.1
• Coordinates: 121605..121886 (+)
• Length: 94 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: -
• Locus tag: BWD162_RS00465
• Protein ID: WP_078704974.1
• Coordinates: 121904..122203 (+)
• Length: 100 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
BWD162_RS00450	120233..120616	+	384	WP_078704972.1	hypothetical protein	-
BWD162_RS00455	120619..121392	+	774	WP_153300973.1	hypothetical protein	-
BWD162_RS00460	121605..121886	+	282	WP_010703127.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
BWD162_RS00465	121904..122203	+	300	WP_078704974.1	HigA family addiction module antidote protein	Antitoxin
BWD162_RS00470	122260..123299	-	1040	Protein_91	tyrosine-type recombinase/integrase	-
BWD162_RS00475	123309..123521	-	213	WP_078704975.1	hypothetical protein	-
BWD162_RS00480	123640..124260	-	621	WP_078704976.1	YqaJ viral recombinase family protein	-
BWD162_RS00485	124262..125047	-	786	WP_078704977.1	phage recombination protein Bet	-
BWD162_RS00490	125188..125865	-	678	WP_078704978.1	hypothetical protein	-
BWD162_RS00495	125902..126213	-	312	WP_078704979.1	antA/AntB antirepressor family protein	-
BWD162_RS00500	126213..126626	-	414	WP_078704980.1	hypothetical protein	-
BWD162_RS00505	126818..127129	-	312	WP_010702522.1	transcriptional regulator	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-1 (1-93)

Antitoxin

• Cro/C1-type helix-turn-helix domain (9-56)

Sequences

Toxin

Protein

• Length: 94 a.a.
• Molecular weight: 10523.31 Da
• Isoelectric Point: 10.1032

>T73297 WP_010703127.1 NZ_CP019781:121605-121886 [Bartonella sp. WD16.2]
MAIVSFKHKGLKLFYTTGSTKAIQAAHAKKLRVILTALTSATCPEMLKAPAFKIHSLKGELTGYYSIWVNGNWRITFRFI
GTDVELVDYQDYH

Nucleotide

• Length: 282 bp

>T73297 NZ_CP019781:121605-121886 [Bartonella sp. WD16.2]
ATGGCAATTGTAAGCTTCAAGCATAAAGGCCTAAAATTATTTTACACGACGGGTTCCACTAAAGCTATTCAAGCAGCTCA
CGCAAAAAAGTTACGTGTTATTTTAACGGCTTTAACAAGTGCTACGTGCCCTGAAATGTTGAAAGCACCTGCTTTTAAAA
TACACTCTCTTAAAGGCGAACTTACAGGCTACTATTCTATATGGGTTAACGGCAATTGGCGCATTACATTTCGTTTTATC
GGAACAGACGTTGAGCTTGTTGATTATCAAGATTACCATTGA

Antitoxin

Protein

• Length: 100 a.a.
• Molecular weight: 11199.96 Da
• Isoelectric Point: 8.7328

>AT73297 WP_078704974.1 NZ_CP019781:121904-122203 [Bartonella sp. WD16.2]
MMHNPAHPGEVLKVAFLEEMDITIQKLADHLHVTRASLSRVINGHASMSTELAVKLELAGFSKAKFWLDMQTNYNLWQAR
QRAQPSIRPLVSDTTQMSL

Nucleotide

• Length: 300 bp

>AT73297 NZ_CP019781:121904-122203 [Bartonella sp. WD16.2]
ATGATGCATAACCCTGCACATCCAGGCGAAGTTCTAAAAGTGGCTTTTTTAGAAGAAATGGATATAACAATACAAAAATT
AGCCGATCATCTCCATGTAACAAGAGCTTCTCTATCAAGAGTTATTAATGGACATGCTTCTATGAGCACCGAACTTGCAG
TTAAATTAGAATTAGCTGGTTTTAGTAAAGCGAAGTTTTGGTTAGATATGCAAACAAACTATAATTTATGGCAAGCAAGG
CAACGAGCACAACCATCTATTCGTCCTCTGGTTTCTGATACTACTCAAATGTCGCTTTGA

Structures

Toxin

• AlphaFold DB: N6UCW6