Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-YefM
Location 6120130..6120644 Replicon chromosome
Accession NZ_CP019724
Organism Streptomyces pactum strain ACT12

Toxin (Protein)


Gene name yoeB Uniprot ID -
Locus tag B1H29_RS26165 Protein ID WP_055416608.1
Coordinates 6120130..6120384 (-) Length 85 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID -
Locus tag B1H29_RS26170 Protein ID WP_055416607.1
Coordinates 6120381..6120644 (-) Length 88 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
B1H29_RS26145 6116440..6117108 + 669 WP_055416612.1 DUF3105 domain-containing protein -
B1H29_RS26150 6117105..6117731 + 627 WP_055416611.1 DUF305 domain-containing protein -
B1H29_RS26155 6117797..6119551 + 1755 WP_055416610.1 NAD+ synthase -
B1H29_RS26160 6119567..6120016 - 450 WP_055416609.1 VOC family protein -
B1H29_RS26165 6120130..6120384 - 255 WP_055416608.1 Txe/YoeB family addiction module toxin Toxin
B1H29_RS26170 6120381..6120644 - 264 WP_055416607.1 type II toxin-antitoxin system prevent-host-death family antitoxin Antitoxin
B1H29_RS26180 6120840..6123848 + 3009 WP_055416606.1 bifunctional [glutamine synthetase] adenylyltransferase/[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase -
B1H29_RS26185 6123982..6124875 - 894 WP_055416605.1 zinc-binding dehydrogenase -
B1H29_RS26190 6124947..6125534 + 588 WP_055416604.1 TetR family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(2-72)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 9969.31 Da        Isoelectric Point: 9.7377

>T73218 WP_055416608.1 NZ_CP019724:c6120384-6120130 [Streptomyces pactum]
VRITFTSHGWEDYVHWAESDRKVTKRINRLITDITRDPFKGIGKPEPLKGDLSGYWSRRIDDTHRLVYKPADDVLVIVQA
RYHY

Download         Length: 255 bp

>T73218 NZ_CP019724:c6120384-6120130 [Streptomyces pactum]
GTGAGGATCACTTTCACGTCGCACGGCTGGGAGGACTACGTCCACTGGGCCGAGAGCGACCGGAAGGTGACCAAGCGGAT
CAACAGACTGATCACCGACATCACACGTGACCCGTTCAAGGGCATCGGCAAGCCGGAGCCGCTGAAGGGCGACCTGTCGG
GTTACTGGTCGCGTCGCATCGACGACACACACCGTCTGGTGTACAAGCCCGCCGATGACGTGCTGGTCATCGTGCAGGCG
CGCTACCACTACTGA

Antitoxin


Download         Length: 88 a.a.        Molecular weight: 9809.93 Da        Isoelectric Point: 5.1421

>AT73218 WP_055416607.1 NZ_CP019724:c6120644-6120381 [Streptomyces pactum]
MSITASEARQNLFPLIEQVNEDHAPVHITSRRGNAVLMSEEDFTAWTETVHLLRSPKNARRLLDSIAEAESGAARRRELI
DPDAERT

Download         Length: 264 bp

>AT73218 NZ_CP019724:c6120644-6120381 [Streptomyces pactum]
ATGTCCATCACCGCCAGCGAAGCCCGTCAGAACCTGTTCCCGCTGATAGAGCAGGTCAACGAGGACCACGCCCCGGTGCA
CATCACCTCCCGCAGGGGAAACGCCGTGCTCATGTCCGAGGAGGACTTCACGGCCTGGACGGAGACGGTCCACCTCCTGC
GCTCCCCCAAGAACGCCCGCCGCCTGCTCGACTCCATCGCCGAGGCCGAGTCCGGCGCCGCGCGCCGGCGCGAGCTCATC
GATCCGGACGCGGAGCGCACGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References